本文選題：特發(fā)性膜性腎病 + 流行病學(xué)��； 參考：《中國實用內(nèi)科雜志》2017年07期

【摘要】：目的揭示特發(fā)性膜性腎病(IMN)的流行病學(xué)變遷,為IMN的防治提供數(shù)據(jù)支持。方法以2010-01-01—2015-12-31期間在鄭州大學(xué)第一附屬醫(yī)院腎臟病病理實驗室診斷的所有患者為研究對象,設(shè)計調(diào)查表,收集患者的人口學(xué)資料、臨床化驗、病理等相關(guān)資料,分析IMN的構(gòu)成比和變遷。結(jié)果共納入19 172例腎活檢標(biāo)本,其中原發(fā)性腎小球病13 147例(68.57%),繼發(fā)腎小球病5355例(27.93%)例。本研究共篩選出IMN 3679例,男性占53.8%,女性占46.2%。平均年齡(47.61±14.78)歲,男性平均年齡高于女性[(48.69±14.75)歲對(46.38±14.73)歲,P0.05]。進一步以年齡分層分析顯示,18歲以下IMN患者所占比例自2012年呈上升趨勢。IMN占腎活檢總例數(shù)比例為19.2%,2010-2015年IMN所占比例亦呈逐年增加趨勢(P0.05)。2010-2015年IMN在原發(fā)性腎小球病中所占比例亦呈逐年上升趨勢,所占比例依次為209例(14.5%)、336例(16.8%)、486例(22.6%)、666例(29.4%)、867例(34.4%)、1115例(40.4%)。結(jié)論特發(fā)性膜性腎病患病率近年來逐年攀升,并呈年輕化趨勢,其機制仍需進一步探討。
[Abstract]:Objective to investigate the epidemiological changes of idiopathic membranous nephropathy (IMN) and provide data for the prevention and treatment of IMN. Methods all the patients who were diagnosed in the laboratory of renal pathology in the first affiliated Hospital of Zhengzhou University during 2010-01-01-2015-12-31 were selected as the research objects. The questionnaire was designed to collect the demographic data, clinical tests and pathological data of the patients. The composition ratio and transition of IMN are analyzed. Results A total of 19 172 renal biopsy specimens were included, including 13 147 cases (68. 57%) of primary glomerulopathy and 5355 cases (27. 93%) of secondary glomerulopathy. A total of 3679 cases of IMNs were selected in this study, male 53.8% and female 46.2%. The mean age was (47.61 鹵14.78) years old, the average age of males was higher than that of females [(48.69 鹵14.75) years vs (46.38 鹵14.73) years old, P0.05]. Further age stratification analysis showed that the proportion of IMN patients under 18 years of age had been on the rise since 2012. The proportion of IMN to total renal biopsy cases was 19.2and the proportion of IMN from 2010 to 2015 was also increasing year by year (P0.05) .IMN in primary glomerulopathy from 2010 to 2015. The proportion also shows an upward trend year by year. The proportion was 209 cases (14.5%), 336 cases (16.8%), 486 cases (22.6%), 666 cases (29.4%), 867 cases (34.4%), 1115 cases (40.4%). Conclusion the prevalence rate of idiopathic membranous nephropathy has been increasing in recent years and showing a trend of rejuvenation. The mechanism of idiopathic membranous nephropathy needs to be further explored.
【作者單位】： 鄭州大學(xué)第一附屬醫(yī)院腎臟病中心鄭州大學(xué)腎臟病研究所;
【基金】：河南省自然科學(xué)基金面上項目(162300410282)
【分類號】：R181.3;R692
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本文編號：2096098