本文選題：流行性腮腺炎 + 流行病學(xué)特征��； 參考：《新疆醫(yī)科大學(xué)》2011年碩士論文

【摘要】：目的：對(duì)石河子市2005年-2009年傳染病網(wǎng)絡(luò)直報(bào)系統(tǒng)流行性腮腺炎病例資料進(jìn)行統(tǒng)計(jì)學(xué)分析,了解石河子市流行性腮腺炎的發(fā)病情況。對(duì)石河子市1～8歲兒童接種流行性腮腺炎疫苗后的抗體陽性率進(jìn)行分析,了解石河子市兒童接種腮腺炎疫苗后的抗體水平,為制定和調(diào)整流行性腮腺炎預(yù)防控制策略提供依據(jù)。方法：1.采用回顧性調(diào)查的方法對(duì)石河子市2005～2009年流行性腮腺炎疫情資料進(jìn)行描述流行病學(xué)分析。2.應(yīng)用現(xiàn)況調(diào)查對(duì)石河子市1～8歲接種過流行性腮腺炎活疫苗的兒童,用組群抽樣的抽樣方法,隨機(jī)抽取769名,采用血清間接酶聯(lián)免疫法定性測定腮腺炎抗體IgG。結(jié)果：1.石河子市2005-2009年共報(bào)告流行性腮腺炎771例,年平均發(fā)病率45.95/10萬,發(fā)病率總體呈現(xiàn)明顯的上升趨勢(shì),發(fā)病有明顯的季節(jié)性,6月的病例報(bào)告最多,在春夏之交形成明顯的發(fā)病高峰,男性發(fā)病明顯超過女性,男女性別比是1.909：1,4～19歲占報(bào)告病例總數(shù)的83.11%,學(xué)生占報(bào)告病例總數(shù)的71.08%,學(xué)齡前兒童占報(bào)告病例總數(shù)的22.31%,病例中有腮腺炎疫苗免疫史占31.65%；病例中1～8歲兒童中,有腮腺炎疫苗免疫史的占48.77%。2.對(duì)石河子市1～8歲兒童腮腺炎免疫狀況調(diào)查,1～8歲兒童腮腺炎抗體陽性率平均為54.23%,1～歲組的抗體陽性率最低(31.15%),2～歲組抗體陽性率最高(67.19%),2～歲組以后隨年齡的增長抗體水平呈逐漸下降趨勢(shì),并進(jìn)行趨勢(shì)卡方檢驗(yàn)有顯著的統(tǒng)計(jì)學(xué)意義(X2=477.22,P0.005),男女間腮腺炎抗體陽性率無顯著性差異(X2=0.077,P0.05),常住兒童抗體陽性率高于暫住人口(X2=3.92,P0.05),有顯著性差異。結(jié)論：1.石河子市2005-2009年腮腺炎發(fā)病率總體呈現(xiàn)明顯的上升趨勢(shì),發(fā)病有明顯的季節(jié)性,男性發(fā)病高于女性,以集體生活為主的在校學(xué)生,是危險(xiǎn)性較大的群體,發(fā)病人群中接種率較低。2.石河子市1～8歲兒童腮腺炎疫苗免疫后抗體陽性率較低,并隨著年齡的增長抗體水平有下降的趨勢(shì),接種1劑次腮腺炎疫苗后,腮腺炎抗體陽性率處于較低水平,建議采取2劑次的接種方案。
[Abstract]:Objective: to study the incidence of epidemic mumps in Shihezi city from 2005 to 2009 by statistical analysis of epidemic mumps cases. The positive rate of antibody after inoculation of mumps vaccine in children aged 1 to 8 years old in Shihezi city was analyzed, and the antibody level of children in Shihezi city after inoculation of mumps vaccine was understood. To provide the basis for formulating and adjusting the prevention and control strategy of mumps. Method 1: 1. The epidemic data of mumps from 2005 to 2009 in Shihezi city were analyzed by retrospective investigation. A survey was conducted on 769 children who had been vaccinated with live mumps vaccine for mumps in Shihezi city aged 1 ~ 8 years, and 769 cases were randomly selected by cluster sampling, and IgG of mumps antibody was determined qualitatively by indirect enzyme-linked immunosorbent assay (Elisa) in serum. The result is 1: 1. A total of 771 cases of mumps were reported in Shihezi City from 2005 to 2009, with an average annual incidence rate of 45.95% / 10 million. The incidence rate showed an obvious upward trend, and the incidence rate was obviously seasonal. The most cases were reported in June, and the peak incidence occurred between spring and summer. The incidence rate of male was significantly higher than that of female. The ratio of male to female was 1.909: 1: 40.19 years old, accounting for 83.11% of the total reported cases, students accounted for 71.08% of the total reported cases, preschool children accounted for 22.31% of the total reported cases, and the mumps vaccine immunization history accounted for 31.65% in the cases. Among children aged 1 to 8 years, 48.77. 2 had a history of mumps vaccine immunization. An investigation on the immune status of mumps in children aged 1 ~ 8 years old in Shihezi City. The average positive rate of mumps antibody in children aged 8 years is 54.23 years old, the lowest (31.15%) is the antibody positive rate of mumps antibody in the group of 2 ~ year old (67.19%), and the positive rate of antibody is the highest in the group of 2 ~ years of age. The increase of antibody level showed a decreasing trend, The positive rate of mumps antibody was not significantly different between male and female (X2 + 0.07 0. 05), and the positive rate of antibody in resident children was higher than that in transient population (X2 + 3. 92P 0.05), and there was a significant difference in the positive rate of mumps antibody between male and female. Conclusion 1. The incidence of mumps in Shihezi city from 2005 to 2009 showed an obvious upward trend, and the incidence of mumps was obviously seasonal. The incidence of male was higher than that of female. The positive rate of mumps antibody in children aged 1 to 8 years old in Shihezi city was lower after immunization, and the antibody level decreased with the increase of age. The positive rate of mumps antibody was at a lower level after inoculating 1 dose of mumps vaccine. Two doses of inoculation were recommended.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2011
【分類號(hào)】：R181.3

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