本文選題：麻疹 + 抗體　； 參考：《現(xiàn)代預(yù)防醫(yī)學(xué)》2017年04期

【摘要】：目的了解開封市健康人群麻疹抗體水平,探尋免疫預(yù)防重點人群。方法采用酶聯(lián)免疫吸附試驗(ELISA)對開封市健康人群進(jìn)行麻疹I(lǐng)g G抗體水平血清學(xué)檢測,并對結(jié)果進(jìn)行統(tǒng)計學(xué)分析。結(jié)果 1 878名調(diào)查對象麻疹抗體陽性率為75.99%(1 427/1 878);抗體達(dá)保護(hù)性水平的比率為42.39%(796/1878),抗體幾何平均濃度(GMC)為330.31IU/L。各年齡組人群麻疹抗體陽性率和抗體GMC差異均有統(tǒng)計學(xué)意義(χ2=648.59,P0.001;F=127.61,P0.01)。其中,1歲以下嬰兒抗體陽性率和GMC分別為45.00%(333/740)、103.02IU/L;20~29歲青年為93.79%(166/177)、645.43IU/L;1~4歲兒童GMC最高,為982.01IU/L;而40歲以上人群抗體陽性率最高,為98.48%。城鎮(zhèn)人群麻疹抗體GMC(364.51IU/L)高于農(nóng)村人群(293.37IU/L)。患過麻疹的人群抗體陽性率和GMC分別為99.39%、998.96IU/L均高于未患人群(67.68%、222.73IU/L)。既往接種過含麻疹成分疫苗的人群抗體陽性率和GMC分別為89.23%、591.07IU/L均高于未種人群(66.58%、218.14IU/L)。結(jié)論開封市患過麻疹、接種含麻疫苗的人群抗體水平高,而1歲嬰兒和20~29歲人群抗體水平較低,為麻疹防控重點人群,需通過綜合性免疫策略來進(jìn)一步提高其抗體水平。
[Abstract]:Objective to investigate the level of measles antibody in Kaifeng healthy population and to explore the key population of immunization prevention. Methods Elisa Elisa was used to detect the serum level of measles IgG antibody in healthy population of Kaifeng City and the results were analyzed statistically. Results the positive rate of measles antibody in 1 878 subjects was 75.999.The ratio of antibody to protective level was 42.39 / 1878, and the geometric mean concentration of antibody was 330.31 IUP / L. There were significant differences in measles antibody positive rate and antibody GMC among different age groups (蠂 ~ 2 ~ 2 ~ (648.59) (P ~ (0.001) P ~ (0.001) P ~ (0.01). The positive rates of antibody and GMC in infants under 1 year of age were 45.00% and 103.02%, respectively. The positive rates of GMC were 93.797,166 / 1777.76% and 645.43 IUL / L / 4 years old, respectively, and the highest positive rate of antibody was 98.488.The positive rate of antibody in infants under 1 year old was 982.01 IUR / L, and the positive rate was 98.481.The positive rate of GMC in infants under 1 year of age was the highest (P < 0.05), and the positive rate of GMC in children over 40 years old was 98.48.5%. The measles antibody GMC 364.51IUP / L in urban population was higher than that in rural population (293.37 IUR / L). The positive rate of antibody and GMC in the people with measles were 99.399.96IUL and 998.96IUL, respectively, which were higher than those in the unaffected population (67.68) and 222.73 (IUP / L), respectively. The positive rate of antibody and GMC of those who had been vaccinated with measles vaccine were 89.23% and 591.07%, respectively, which were higher than that of unseeded population (66.58%) and 218.14% IUL / L respectively. Conclusion the antibody level of measles in Kaifeng city is higher than that of 1 year old infant and 20 ~ 29 year old group. It is the key population of measles prevention and control. It is necessary to further improve the antibody level through comprehensive immunization strategy.
【作者單位】： 河南省開封市疾病預(yù)防控制中心;河南大學(xué)第一附屬醫(yī)院;
【基金】：開封市科技發(fā)展計劃項目(項目號130332)
【分類號】：R511.1;R186

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