本文選題：慢性阻塞性肺疾病 + 流行病學(xué)��； 參考：《南昌大學(xué)》2017年碩士論文

【摘要】：背景:慢性阻塞性肺疾病(COPD)是最常見的慢性呼吸系統(tǒng)疾病,它可以累及全身各個(gè)器官系統(tǒng)。由于COPD病程遷延,患病人數(shù)較多,致殘率及病死率較高,患者的生活質(zhì)量受到嚴(yán)重影響,同時(shí)也給家庭和社會(huì)帶來(lái)了沉重的經(jīng)濟(jì)以及社會(huì)負(fù)擔(dān)。COPD危險(xiǎn)因素種類繁多,作用機(jī)制不盡相同,因此了解COPD的流行病學(xué)、識(shí)別其各種可干預(yù)危險(xiǎn)因素,對(duì)COPD的防治尤為重要。目的:通過(guò)綜述COPD的流行病學(xué)、各種可干預(yù)危險(xiǎn)因素及不可干預(yù)危險(xiǎn)因素方面的研究,為COPD的防治提供一些參考。方法:以“COPD,流行病學(xué),危險(xiǎn)因素”等關(guān)鍵詞進(jìn)行搜索,找出COPD流行病學(xué)及危險(xiǎn)因素方面的最新研究。結(jié)論:目前全世界各個(gè)地區(qū)有大量COPD流行病學(xué)及危險(xiǎn)因素方面的研究,綜合這些研究結(jié)果表明:COPD的患病率呈逐年增長(zhǎng)的趨勢(shì),給家庭及社會(huì)帶來(lái)沉重的經(jīng)濟(jì)負(fù)擔(dān);在COPD眾多危險(xiǎn)因素中,目前被完全確認(rèn)的危險(xiǎn)因素是吸煙及絲氨酸蛋白酶抑制劑家族基因1;空氣污染、職業(yè)粉塵暴露、肺的生長(zhǎng)發(fā)育、體重指數(shù)、年齡及其他遺傳基因等危險(xiǎn)因素與COPD的關(guān)系需進(jìn)一步探索;提高各層面人群對(duì)COPD的認(rèn)知度,盡早對(duì)可干預(yù)危險(xiǎn)因素進(jìn)行干預(yù),對(duì)COPD防治意義重大。
[Abstract]:Background: chronic obstructive pulmonary disease (COPD) is the most common chronic respiratory disease. As the course of COPD is prolonged, the number of patients is large, the rate of disability and mortality is high, the quality of life of the patients is seriously affected, and at the same time, it brings a heavy economic and social burden to the family and society, and there are many kinds of risk factors. The mechanism of action is different, so it is very important to understand the epidemiology of COPD and identify its interventional risk factors for the prevention and treatment of COPD. Objective: to provide some references for the prevention and treatment of COPD by reviewing the epidemiology, interventional risk factors and non-interventional risk factors of COPD. Methods: to find out the latest research on COPD epidemiology and risk factors by searching for the keywords of "copd, epidemiology, risk factors". Conclusion: there are a large number of epidemiology and risk factors of COPD in various regions of the world. The results show that the prevalence of COPD is increasing year by year, which brings a heavy economic burden to families and society. Among the many risk factors for COPD, smoking and serine protease inhibitor family genes 1, air pollution, occupational dust exposure, lung growth and development, body mass index, The relationship between age and other genetic risk factors and COPD should be further explored, and it is of great significance for the prevention and treatment of COPD to improve the recognition of COPD among people at all levels and to intervene in interventional risk factors as soon as possible.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R563.9;R181.3

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