本文選題：赤峰地區(qū) + 幽門螺旋桿菌��； 參考：《大連醫(yī)科大學(xué)》2010年碩士論文

【摘要】： 目的：調(diào)查來我院體檢的健康人群及就診的上消化道疾病患者幽門螺旋桿菌(Helicobacterpylori, Hp)感染情況,以分析赤峰地區(qū)Hp在不同年齡、性別、民族、生活地區(qū)以及不同上消化道疾病之間的感染是否存在差異。 方法：對1000例來我院體檢的城鄉(xiāng)健康人員進行14C尿素呼氣試驗,陽性者為Hp感染；對960名就診的上消化道疾病患者經(jīng)胃鏡、胃粘膜活檢組織診斷,行快速尿素酶檢查及14C呼氣試驗檢測,快速尿素酶試驗和14C呼氣試驗均陽性者為Hp感染。 結(jié)果： 1.健康人群組Hp感染情況： (1)在1000例城鄉(xiāng)健康人群組中,Hp陽性者644人,Hp感染率為64.4%。 (2)性別與Hp感染率1000名健康人群中,男性532人,陽性者344例,Hp感染率為64.7%；女性468人,Hp陽性者為300例,Hp感染率為64.1%,性別比較感染率無統(tǒng)計學(xué)差異(x2=0.003 p0.05)。 (3)年齡構(gòu)成與Hp感染率1000例健康人群組中,年齡分布7-82歲每十歲分為一組,各年齡組Hp感染有所不同,各年齡組Hp感染率分別為33.3%、44.4%、61.8%、69%,70.3%、71.1%、68.6%、57.5%、53.8%,兒童Hp感染率為33.3%,隨著年齡的增長呈上升趨勢,51-60歲達高峰,Hp感染率為71.1%,60歲以后逐漸下降。 (4)民族構(gòu)成與Hp感染率1000例健康人群中,漢族683人,Hp陽性者450例,Hp感染率為65.9%；蒙古族265人,Hp陽性者161人,Hp感染率為60.8%；滿族39人,Hp陽性者25人,Hp感染率為64.1%；回族13人,Hp陽性者8人,Hp感染率為61.5%；經(jīng)兩兩比較民族感染率差異無統(tǒng)計學(xué)意義(x2=0.141,0.052,0.143,0.144,0.181,0.028,p值均0.05)。 (5)生活地區(qū)與Hp感染率1000例健康人群組中城市居民734人,Hp陽性者457例,Hp感染率為62.1%,農(nóng)村居民266人,Hp陽性者188例,Hp感染率為70.7%,農(nóng)村居民感染率Hp感染率明顯高于城市居民感染率,差異有統(tǒng)計學(xué)意義(x2=6.23 p0.05)。 2.不同上消化道疾病患者組Hp感染率不同上消化道疾病患者960例,其中慢性淺表性胃炎、慢性萎縮性胃炎、胃潰瘍、十二指腸潰瘍及胃癌患者Hp感染率分別為67.7%(302／446)、73.7%(143／194)、83.1%(108／130)、93.7%(133／142)、75%(36／48),十二指腸潰瘍患者、胃潰瘍患者Hp感染率高于其他上消化道疾病患者,差異有統(tǒng)計學(xué)意義(p0.05)。 3.健康人群組與上消化道疾病患者組Hp感染率比較健康人群組1000例受檢人數(shù)中,陽性者644例,Hp感染率為64.4%;上消化道疾病組960例受檢人數(shù)中,陽性者722例,Hp感染率為75.1%；上消化道疾病組Hp感染率明顯高于健康人群組Hp感染率,差異有統(tǒng)計學(xué)意義(X=27.09,p0.05)。 結(jié)論： 1.在赤峰地區(qū)健康人群中Hp感染率為64.4%,高于全國平均自然感染率。 2.赤峰地區(qū)健康人群中,Hp感染率隨著年齡的增長呈上升趨勢,51-60歲達高峰,農(nóng)村居民高于城市居民,但在性別、民族因素上無差異。 3.上消化道疾病患者Hp感染率高于健康人群Hp感染率。 4.不同上消化道疾病患者中Hp感染率不同,以十二指腸潰瘍、胃潰瘍患者Hp感染率最高。
[Abstract]:Objective : To investigate the prevalence of Helicobacter pylori ( Hp ) infection in the healthy population and the upper digestive tract diseases of our hospital in order to analyze the difference of Hp infection between different ages , sex , nationality , living area and different upper digestive tract diseases .



Methods : A total of 1000 healthy persons in urban and rural areas of our hospital were treated with 14C urea breath test , and the positive ones were Hp infection .
Hp infection was detected in 960 patients with upper gastrointestinal tract disease via endoscopy , gastric mucosa biopsy , rapid urease test and 14C breath test , rapid urease test and 14C breath test .



Results :



1 . Hp infection in healthy population group :



( 1 ) Among the 1000 healthy population groups , 644 were Hp positive , and the infection rate of Hp was 64.4 % .



( 2 ) Of the 1000 healthy people with HIV infection rate , 532 were male , 344 were positive , and the infection rate of Hp was 64.7 % .
Among the 468 women , the Hp positive rate was 300 cases , the infection rate of Hp was 64.1 % , and there was no statistical difference between the sex ratio infection rate ( x2 = 0.003 p . 05 ) .



( 3 ) Age distribution and Hp infection rate were among 1000 healthy population groups . Hp infection rate was 33.3 % , 44.4 % , 61.8 % , 69 % , 70.3 % , 71.1 % , 68.6 % , 57.5 % , 53.8 % , 68.6 % , 57.5 % , 53.8 % , 68.6 % , 57.5 % , 53.8 % , 68.6 % , 57.5 % , 53.8 % respectively .



( 4 ) The prevalence rate of Hp infection was 65.9 % in the Han nationality 683 , the Hp positive 450 cases and the Hp infection rate of 1000 healthy people .
The rate of Hp infection was 60.8 % among 265 Mongolian and 161 Hp - positive persons .
The infection rate of Hp was 64.1 % .
The infection rate of Hp was 61.5 % .
There was no significant difference between the two groups ( x2 = 0.141 , 0.052 , 0.143 , 0.144 , 0.181 , 0.028 , p < 0.05 ) .



( 5 ) There were 734 persons in the healthy population group living in the living area and the Hp infection rate , 457 cases of Hp positive persons , 62.1 % of Hp infection rate , 266 rural residents , 188 cases of Hp positive , 70.7 % of Hp infection rate , and the infection rate of rural residents was significantly higher than that of urban residents ( x2 = 6.23 p . 05 ) .



2 . Hp infection rate in patients with different upper digestive tract diseases was 67.7 % ( 302 / 446 ) , 73.7 % ( 143 / 194 ) , 83.1 % ( 108 / 130 ) , 93.7 % ( 133 / 142 ) , 75 % ( 36 / 48 ) , duodenal ulcer patients and gastric ulcer patients with Hp infection rate of 67.7 % ( 302 / 446 ) , 93.7 % ( 133 / 142 ) , 75 % ( 36 / 48 ) and duodenal ulcer respectively .



3 . In the healthy population group , the Hp infection rate in the healthy population group was compared with that of the healthy population group . 644 cases were positive , the infection rate of Hp was 64.4 % , and in the upper digestive tract disease group , there were 722 cases of positive persons and 75.1 % of Hp infection rate .
Hp infection rate in upper gastrointestinal tract group was significantly higher than that in healthy population group ( X = 27.09 , p < 0.05 ) .



Conclusion :



1 . The infection rate of Hp in the healthy population in Chifeng area was 64.4 % , which was higher than the national average infection rate .



2 . In the healthy population of Chifeng area , the infection rate of Hp is increasing with the age , 51 - 60 years old , rural residents are higher than urban residents , but there is no difference in sex and ethnicity .



3 . Hp infection rate in upper gastrointestinal disease patients is higher than that in healthy population .



4 . Hp infection rate was different in patients with different upper digestive tract diseases . Hp infection rate was the highest in patients with duodenal ulcer and gastric ulcer .

【學(xué)位授予單位】：大連醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R181.3;R57

【引證文獻】

相關(guān)期刊論文 前1條

1 丁建輝;;老年消化性潰瘍的臨床診治特點分析[J];求醫(yī)問藥(下半月);2012年08期

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本文編號：1873504