中國(guó)肺結(jié)核治療失敗影響因素的Meta分析
發(fā)布時(shí)間:2018-04-29 15:14
本文選題:結(jié)核 + 肺; 參考:《中華疾病控制雜志》2014年02期
【摘要】:目的探討肺結(jié)核治療失敗的影響因素,為今后防治工作提供依據(jù)。方法對(duì)PubMed、CNKI、VIP、CBM及萬(wàn)方數(shù)據(jù)庫(kù)進(jìn)行檢索關(guān)于肺結(jié)核治療失敗影響因素的研究(2002-2012年),通過(guò)Meta分析,報(bào)告危險(xiǎn)因素的合并OR(95%CI)值。結(jié)果共納入符合標(biāo)準(zhǔn)的文獻(xiàn)15篇,單因素分析,合并OR(95%CI)值分別為:合并癥2.71(1.99~3.70)、肺病空洞2.16(1.75~2.66)、病變肺野數(shù)4.88(2.76~8.62)、低蛋白血癥3.57(2.61~4.90)、不規(guī)律治療28.09(4.90~161.06)、治療延誤3個(gè)月5.42(1.53~19.15)、吸煙3.47(2.20~5.46)、不良反應(yīng)2.08(1.46~2.98)、耐藥3.30(1.24~8.76);多因素分析,OR(95%CI)值分別為:合并癥2.51(1.85~3.41)、肺部空洞1.77(1.39~2.26)、病變肺野數(shù)1.38(1.26~1.51)、不規(guī)律治療19.83(2.83~138.76)、治療延誤3個(gè)月2.35(1.42~3.91)、不良反應(yīng)2.14(1.49~3.06)、耐藥2.45(1.37~4.38),指標(biāo)差異均有統(tǒng)計(jì)學(xué)意義。結(jié)論合并癥、肺部空洞、病變肺野數(shù)、低蛋白血癥、不規(guī)律治療、治療延誤、吸煙、不良反應(yīng)、耐藥均是肺結(jié)核治療失敗的影響因素。
[Abstract]:Objective to explore the factors influencing the failure of pulmonary tuberculosis treatment and to provide basis for future prevention and treatment. Methods the study on the influencing factors of pulmonary tuberculosis failure was carried out by searching the CBM of CNKI Meta and Wanfang database. By Meta analysis, the combined OR95 value of risk factors was reported. Results A total of 15 articles were included to meet the criteria, and a single factor analysis was carried out. 鍚堝茍OR(95%CI)鍊煎垎鍒負(fù):鍚堝茍鐥,
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