本文選題：克雅氏病 + 監(jiān)測(cè)��； 參考：《中國人獸共患病學(xué)報(bào)》2017年11期

【摘要】：目的了解陜西省克雅氏病(Creutzfeldt-Jakob disease,CJD)的發(fā)病情況、臨床表現(xiàn)及流行病學(xué)特征,為科學(xué)防控CJD提供依據(jù)。方法采集了2011-2015年陜西省7家醫(yī)院報(bào)告的49例可疑CJD病例的臨床及流行病學(xué)信息,收集了患者的血液及腦脊液樣本。對(duì)腦脊液樣本,通過免疫印跡法檢測(cè)14-3-3蛋白。對(duì)血液樣本,提取核酸,通過聚合酶鏈反應(yīng),擴(kuò)增朊蛋白基因;利用測(cè)序技術(shù),測(cè)定其突變情況,同時(shí)對(duì)129位和219位氨基酸進(jìn)行多態(tài)性分析。結(jié)果確定散發(fā)型CJD臨床診斷病例16例,散發(fā)型CJD疑似診斷病例4例,遺傳型CJD 1例。病例的地理分布和職業(yè)無明顯聚集性;散發(fā)型CJD臨床診斷病例發(fā)病年齡中位數(shù)為62歲,男女比例1.29∶1;快速進(jìn)行性癡呆為最常見的首發(fā)癥狀,占全部診斷病例的47.62%。結(jié)論陜西監(jiān)測(cè)到的CJD病例主要為散發(fā)型CJD,收集到的病例的年齡、性別比例、職業(yè)情況及住址分布等均符合散發(fā)型CJD的分布特點(diǎn)。
[Abstract]:Objective to investigate the incidence, clinical manifestation and epidemiological characteristics of Creutzfeldt-Jakob disease (CJDD) in Shaanxi Province, so as to provide scientific basis for the prevention and control of CJD. Methods the clinical and epidemiological information of 49 suspected CJD cases reported in 7 hospitals in Shaanxi Province from 2011 to 2015 were collected and the blood and cerebrospinal fluid samples were collected. The 14-3-3 protein was detected by Western blotting in cerebrospinal fluid (CSF) samples. Nucleic acid was extracted from blood samples and prion gene was amplified by polymerase chain reaction (PCR). The mutation of prion protein gene was determined by sequencing and the polymorphism of 129 and 219 amino acids was analyzed. Results 16 cases of sporadic CJD were clinically diagnosed, 4 cases of sporadic CJD were suspected, and 1 case of hereditary CJD was found. The median age of clinical diagnosis of sporadic CJD was 62 years old, the ratio of male to female was 1.29: 1, and rapid progressive dementia was the most common initial symptom, accounting for 47.62% of all cases. Conclusion the main CJD cases monitored in Shaanxi are sporadic CJD. The age, sex ratio, occupation status and address distribution of the collected cases are consistent with the distribution characteristics of sporadic CJD.
【作者單位】： 陜西省疾病預(yù)防控制中心病毒病預(yù)防控制所;
【基金】：“十二·五”國家科技重大專項(xiàng)(No.2013ZX10004202-001-002)~~
【分類號(hào)】：R181.3;R742.9

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