本文選題：飲酒 + 酒精性肝病�。� 參考：《吉林大學(xué)》2008年博士論文

【摘要】： 2006年2月,世界衛(wèi)生組織向中國政府提交了《西太平洋地區(qū)減少酒精危害計(jì)劃》的報(bào)告,報(bào)告認(rèn)為中國人在飲酒量、飲酒環(huán)境和年消耗量方面嚴(yán)重危害著健康。因此,我國需要通過一套科學(xué)評估體系和調(diào)查方法來了解中國人的健康飲酒狀況。目前許多疾病被證實(shí)系由飲酒所致,其中ALD發(fā)病率高、危害大。然而,人們對ALD的嚴(yán)重性及危害性認(rèn)識不足,并且人們認(rèn)識到遺傳組成不同的個體對不同疾病的易感性不同。DNA芯片高通量的特點(diǎn)能夠快速準(zhǔn)確地得出所需信息,從而實(shí)現(xiàn)對ALD易感人群快速準(zhǔn)確的篩選。 本實(shí)驗(yàn)采用多階段(分層、系統(tǒng))抽樣的方法抽取樣本,應(yīng)用“吉林省城鄉(xiāng)居民飲食健康調(diào)查問卷”對德惠市6043名18歲以上常住居民進(jìn)行問卷調(diào)查,包括五大類43個詢問內(nèi)容,對其中3815名居民進(jìn)行了醫(yī)學(xué)體檢;對該人群的酒精飲用情況及酒精對肝功、血脂、血壓、體重指數(shù)、平均紅細(xì)胞體積等的影響進(jìn)行了分析;對ALD的患病率進(jìn)行了統(tǒng)計(jì),并分析與之相關(guān)的危險(xiǎn)因素;采用Affymetrix Genome-Wide Human SNP Array 5.0芯片對120例ALD全基因組的SNPs位點(diǎn)進(jìn)行篩查,并進(jìn)行了酒精代謝酶基因多態(tài)性與ALD的關(guān)聯(lián)分析。 本次流行病學(xué)調(diào)查有效問卷6043份。樣本飲酒率35.0%,飲酒者平均日飲酒量36.97±48.76g,總酒精攝入量297.90±506.52kg,平均飲酒年限19.21±11.34年,證實(shí)飲酒是中國一種較為普遍的社會性行為,隨著日飲酒量的增加,γ-GT、AST、ALT、MCV、Chol、TG、LDL-c、HDL-c和BP的平均值逐漸增加,γ-GT、AST、ALT、MCV、Chol、TG、LDL-c、HDL-c和BP與酒精量呈正相關(guān),血脂、肝功、BMI和MCV異常率在飲酒人群和非飲酒人群單因素分析具有統(tǒng)計(jì)學(xué)意義,Logistic多元回歸分析顯示地區(qū)、年齡、γ-GT、AST、ALT、Chol和MCV與飲酒密切相關(guān)。ALD在體檢人群中的患病率3.98%,在飲酒者中患病率11.76%,在嗜酒者中患病率44.17%。隨著日飲酒量的增加和飲酒年限的延長,ALD的患病率逐漸增加。Logistic多元回歸分析顯示SBP、γ-GT、AST、LDL-c和酒精量與ALD的發(fā)生密切相關(guān)。中國人漢族北方種群中共有6個酒精代謝酶的SNPs位點(diǎn)與ALD密切相關(guān)。 本實(shí)驗(yàn)采用標(biāo)準(zhǔn)的流行病學(xué)調(diào)查方法,首次在吉林省德惠市進(jìn)行了飲酒及ALD相關(guān)危險(xiǎn)因素的調(diào)查、統(tǒng)計(jì)和分析,并對120例ALD人群全基因組的SNPs位點(diǎn)進(jìn)行篩查及酒精代謝酶基因多態(tài)性與ALD的關(guān)聯(lián)分析。明確飲酒與疾病的相關(guān)性;了解當(dāng)前酒精應(yīng)用的類型和方式、飲酒者的人口學(xué)特征,及時獲得反映吉林省德惠市當(dāng)前飲酒及ALD患病情況的代表性統(tǒng)計(jì)數(shù)據(jù),為國家制定相關(guān)衛(wèi)生和營養(yǎng)政策、開展疾病防治和教育提供科學(xué)依據(jù);為進(jìn)一步開展全國性的調(diào)查和在飲酒人群中進(jìn)行ALD易感者患病風(fēng)險(xiǎn)的篩查、診斷和有效治療奠定基礎(chǔ)。
[Abstract]:In February 2006, the World Health Organization (WHO) submitted to the Chinese government a report on the "Western Pacific region Alcohol Hazard reduction Program", which concluded that Chinese people are seriously harmful to their health in terms of alcohol consumption, drinking environment and annual consumption. Therefore, we need a set of scientific evaluation system and survey methods to understand the healthy drinking status of Chinese people. At present, many diseases have been proved to be caused by alcohol consumption, among which ALD incidence is high and harmful. However, there is a lack of understanding of the severity and harm of ALD, and it is recognized that individuals with different genetic composition have different susceptibility to different diseases. The high throughput characteristics of DNA chips can quickly and accurately obtain the required information. In order to achieve rapid and accurate screening of susceptible populations for ALD. In this experiment, multi-stage (stratified, systematic) sampling method was used to collect samples, and 6043 residents over 18 years old in Dehui city were investigated by "questionnaire on dietary health of urban and rural residents of Jilin Province", including 43 inquiries in five categories. 3815 of them were examined by medical examination, and the effects of alcohol consumption on liver function, blood lipids, blood pressure, body mass index, mean red blood cell volume and so on were analyzed. The prevalence of ALD was analyzed. The Affymetrix Genome-Wide Human SNP Array 5.0 microarray was used to screen SNPs loci in 120 ALD genome, and the association between the polymorphism of alcohol metabolic enzyme gene and ALD was analyzed. There were 6043 valid questionnaires in this epidemiological survey. The average daily alcohol consumption, total alcohol intake and average drinking time were 36.97 鹵48.76g, 297.90 鹵506.52 kg and 19.21 鹵11.34 years, respectively. The results showed that drinking was a common social behavior in China. With the increase of daily alcohol consumption, the average values of LDL-c and BP increased gradually in MCVV Choll TGN LDL-c and BP, and the levels of HDL-c and BP were positively correlated with the amount of alcohol concentrate, and the serum lipids, blood lipid, serum lipids, and serum lipids were positively correlated with the levels of HDL-c and BP. The abnormal rates of MCV and MCV were statistically significant in the univariate analysis of drinkers and non-drinkers. Age, Chol and MCV were closely related to alcohol consumption. The prevalence rate of ALD was 3.98%, 11.76% among drinkers and 44.17% among alcoholics. With the increase of daily alcohol consumption and the prolongation of drinking years, the prevalence rate of ALD increased gradually. Logistic multiple regression analysis showed that SBP, 緯 -GT ASTX LDL-c and alcohol concentration were closely related to the occurrence of ALD. Six SNPs loci of alcohol metabolizing enzymes were closely related to ALD in the northern population of Han nationality in China. By using the standard epidemiological investigation method, the investigation, statistics and analysis of the risk factors related to alcohol consumption and ALD were conducted in Dehui City, Jilin Province for the first time. The SNPs loci of the whole genome of 120 cases of ALD were screened and the association between the polymorphism of alcohol metabolic enzyme gene and ALD was analyzed. To know the types and ways of alcohol use, the demographic characteristics of drinkers, and to obtain the representative statistical data reflecting the current situation of drinking and ALD in Dehui City, Jilin Province, in time, so as to clarify the correlation between alcohol consumption and diseases, understand the types and methods of alcohol use, and obtain the demographic characteristics of drinkers. It provides a scientific basis for the national health and nutrition policy, disease prevention and education, and lays the foundation for further national investigation and screening, diagnosis and effective treatment of the risk of ALD risk among people who are susceptible to ALD.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2008
【分類號】：R181.3

【引證文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 王瑋琳;藍(lán)莓提取物對酒精性肝損傷干預(yù)作用研究[D];吉林大學(xué);2011年

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本文編號：1793924