本文選題：代謝綜合征　切入點：2型糖尿病　出處：《吉林大學(xué)》2007年碩士論文

【摘要】： 代謝綜合征是一種以代謝紊亂為特征的征候群,并已作為2型糖尿病及心血管疾病的獨立預(yù)測因素正越來越受到廣泛關(guān)注。代謝綜合征主要包括中心性肥胖、糖耐量異常、血脂代謝紊亂等危險因素,代謝綜合征患者糖尿病、心血管疾病的發(fā)病率約是正常人群的5倍,嚴重危害人類的身心健康。 1988年Reaven首先提出代謝綜合征的理論,又稱為胰島素抵抗學(xué)說,其核心內(nèi)容是由于機體存在胰島素降糖作用方面生物學(xué)效應(yīng)降低,而其脂代謝、電解質(zhì)代謝作用正常。機體為代償胰島素選擇性生物作用的異常,首先維持糖代謝的平衡,導(dǎo)致高胰島素血癥,而這種繼發(fā)性高胰島素血癥可導(dǎo)致機體脂代謝、離子等代謝異常。因此胰島素抵抗及代償性高胰島素血癥導(dǎo)致機體各種基本營養(yǎng)物質(zhì)代謝紊亂,出現(xiàn)高血壓、肥胖、血脂紊亂、糖尿病、動脈硬化等臨床癥狀,對整個人類健康構(gòu)成嚴重威脅。 代謝綜合征的發(fā)生有一定遺傳因素,但更重要的是生活方式改變造成的惡果。大量流行病學(xué)研究證明隨著各國和各類社會群體富裕程度、生活方式的不同,代謝綜合征相關(guān)疾病發(fā)生率相差懸殊。因此,了解代謝綜合征患病情況,并根據(jù)地區(qū)和不同人群特點進行防治,尤為重要。本文對在2005年5月到7月791例在我院年度體檢的吉林省離退休及在職副廳級以上干部進行了代謝綜合征的流行病學(xué)調(diào)查,了解在該人群中代謝綜合征發(fā)生情況。本組資料顯示:在791例中老年體檢對象中,MS的總患病率為20.1%,整個人群的肥胖/超重占45.3%,高血壓為47.41%,2型糖尿病和糖代謝異�？偘l(fā)生率為28.44%,高甘油三酯血癥為47.28%。2型糖尿病、糖代謝異常和高血壓隨增齡逐步增加,而高甘油三酯血癥和肥胖的發(fā)生率則逐步下降。 本研究顯示調(diào)查人群中代謝綜合征發(fā)生率明顯高于全國平均水平,揭示該人群應(yīng)積極調(diào)整生活方式、降低有關(guān)疾病的發(fā)生、發(fā)展,提高生活質(zhì)量。
[Abstract]:Metabolic syndrome is a syndrome characterized by metabolic disorder, and has been widely concerned as an independent predictor of type 2 diabetes and cardiovascular disease.Metabolic syndrome mainly includes central obesity, abnormal glucose tolerance, dyslipidemia and other risk factors. The incidence of diabetes mellitus and cardiovascular disease in patients with metabolic syndrome is about 5 times as high as that in normal people, which seriously endangers the physical and mental health of human beings.In 1988, Reaven first put forward the theory of metabolic syndrome, also known as insulin resistance theory. The core content of the theory is that the biological effect of insulin hypoglycemia is reduced, but its lipid metabolism and electrolyte metabolism are normal.For the abnormality of selective biological action of compensatory insulin, the first step is to maintain the balance of glucose metabolism, which leads to hyperinsulinemia, and this secondary hyperinsulinemia can lead to abnormal metabolism of lipid and ions.Therefore, insulin resistance and compensatory hyperinsulinemia lead to metabolic disorders of various basic nutrients, hypertension, obesity, dyslipidemia, diabetes, arteriosclerosis and other clinical symptoms, which pose a serious threat to human health.Metabolic syndrome has some genetic factors, but more important is the negative consequences of lifestyle changes.A large number of epidemiological studies have proved that the incidence of metabolic syndrome-related diseases varies greatly with the wealth and lifestyle of different countries and social groups.Therefore, it is important to understand the prevalence of metabolic syndrome and to prevent and cure metabolic syndrome according to regional and different population characteristics.An epidemiological survey of metabolic syndrome was carried out in 791 cases of retired cadres in Jilin Province from May to July 2005, and the incidence of metabolic syndrome in this population was investigated.The incidence of hypertriglyceridemia and obesity decreased with age.This study shows that the incidence of metabolic syndrome in the survey population is significantly higher than the national average. It is revealed that the population should actively adjust their lifestyle, reduce the incidence of related diseases, develop and improve the quality of life.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2007
【分類號】：R589;R181.3

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本文編號：1725804