本文選題：比例失衡分析　切入點(diǎn)：水痘減毒活疫苗　出處：《中國疫苗和免疫》2017年05期

【摘要】：目的利用比例失衡分析(Disproportionality analysis,DPA)偵測廣東省2009-2014年水痘減毒活疫苗(Varicella attenuated live vaccine,VarV)預(yù)防接種異常反應(yīng)的可疑信號。方法通過全國疑似預(yù)防接種異常反應(yīng)(AEFI)信息管理系統(tǒng)收集廣東省2009-2014年有明確診斷的VarV預(yù)防接種異常反應(yīng),利用DPA中頻數(shù)法的報(bào)告比值比(Reporting odds ratio,ROR)和比例報(bào)告比(Proportional reporting ratio,PRR)及貝葉斯法中的貝葉斯置信傳播神經(jīng)網(wǎng)絡(luò)(Bayesian confidence propagation neural network,BCPNN)和模糊貝葉斯伽馬-泊松收縮論(Empirical Bayes Gamma-Poisson Shrinker,GPS)方法檢測可疑信號。結(jié)果共有8 233例明確診斷的預(yù)防接種異常反應(yīng)個案納入分析,其中VarV異常反應(yīng)461例(5.60%),使用ROR、PRR和BCPNN方法分析發(fā)現(xiàn)3個可疑信號,使用GPS方法發(fā)現(xiàn)2個可疑信號;可疑信號主要是接種VarV后的過敏性休克和喉頭水腫。結(jié)論 DPA發(fā)現(xiàn)VarV過敏性休克和喉頭水腫可疑信號增高,需進(jìn)一步開展流行病學(xué)研究驗(yàn)證,并探索適合中國疫苗安全監(jiān)測的數(shù)據(jù)挖掘技術(shù)。
[Abstract]:Objective to detect suspicious signals of abnormal vaccination response of varicella attenuated live varicella live varicella vaccine in Guangdong Province 2009-2014 by using proportion imbalance analysis. Methods A wide range of information management systems were collected through the National Information Management system for the suspected vaccination abnormal response of varicella attenuated live varicella varicella live varicella varicella live varicella attenuated live vaccine in 2009-2014. In 2009-2014, there were clearly diagnosed abnormal VarV vaccination reactions in Eastern Province, Detection of Bayesian confidence propagation neural Network (Bayesian confidence propagation neural Network) and Fuzzy Bayesian Gamma-Poisson contraction Theory empirical Bayes Gamma-Poisson contraction method by using reporting odds ratio and proportional reporting ratio in DPA and Bayesian confidence propagation neural Network (BCPNN) and Bayesian confidence propagation neural Network (BP N) and Bayesian Gamma Poisson contraction Theory (Bayesian Gamma Poisson contraction Theory) and Bayesian confidence propagation neural Network (BP N) and Bayesian Gamma Poisson contraction Theory (BP) method. Results A total of 8,233 clearly diagnosed cases of abnormal vaccination response were included in the analysis. Among them, 461 cases of abnormal reaction of VarV were detected by 5.60%, 3 suspicious signals were detected by RORP PRR and BCPNN method, 2 suspicious signals were detected by GPS method. The suspicious signals were mainly anaphylactic shock and laryngeal edema after inoculation with VarV. Conclusion DPA found that VarV anaphylactic shock and laryngeal edema were increased. And explore the data mining technology suitable for Chinese vaccine safety monitoring.
【作者單位】： 廣東省疾病預(yù)防控制中心;南方醫(yī)科大學(xué)公共衛(wèi)生學(xué)院;
【基金】：廣東省醫(yī)學(xué)科學(xué)研究基金應(yīng)用數(shù)據(jù)挖掘技術(shù)建立疫苗安全監(jiān)測自動預(yù)警系統(tǒng)初步研究(編號B2014019)
【分類號】：R186

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