本文選題：急性弛緩性麻痹　切入點(diǎn)：疫苗變異脊髓灰質(zhì)炎病毒　出處：《現(xiàn)代預(yù)防醫(yī)學(xué)》2014年04期

【摘要】：目的分析一起疑似脊灰疫苗變異株病毒循環(huán)調(diào)查處置過程。方法進(jìn)行病例核實(shí)診斷和個(gè)案調(diào)查,開展醫(yī)院AFP病例主動搜索,評價(jià)AFP病例監(jiān)測系統(tǒng)運(yùn)轉(zhuǎn)情況,調(diào)查密切接觸者兒童糞便帶毒率及脊灰疫苗接種率。結(jié)果在3例病例糞便標(biāo)本中同時(shí)分離到Ⅲ型脊灰病毒,該病毒VP1區(qū)與Sabin疫苗株病毒相比,分別有0.44%、0.55%和0.44%的核苷酸變異。3例病例發(fā)病地點(diǎn)相距較遠(yuǎn),均接種口服脊灰減毒活疫苗(OPV),密切接觸者糞便標(biāo)本未分離到脊灰病毒,當(dāng)?shù)貎和Ｒ?guī)免疫接種率均處較高水平。結(jié)論脊灰疫苗變異株病毒未在當(dāng)?shù)匕l(fā)生循環(huán)。提高AFP監(jiān)測系統(tǒng)敏感性、脊灰疫苗接種率和疫情應(yīng)急能力,是有效阻止脊灰疫苗病毒變異株循環(huán)和脊灰野病毒輸入的有效措施。
[Abstract]:Objective to analyze the process of virus cycle investigation and disposal of a suspected poliomyelitis vaccine variant strain.Methods the case verification diagnosis and case investigation were carried out, and the active search of hospital AFP cases was carried out to evaluate the operation of the AFP case monitoring system, and to investigate the fecal infection rate and poliomyelitis vaccination rate of children in close contact.Results poliovirus type 鈪，

本文編號：1685238