<正>由牙源性干細(xì)胞參與、信號(hào)分子級(jí)聯(lián)網(wǎng)絡(luò)操控的牙齒發(fā)育是一個(gè)有序的過程,牙發(fā)育過程中上皮-間充質(zhì)間相互誘導(dǎo)分化是其機(jī)制的核心。牙齒發(fā)育的本質(zhì)即為來(lái)源于胚胎期牙胚的上皮干細(xì)胞及間充質(zhì)干細(xì)胞形成牙齒。目前已發(fā)現(xiàn)約300種基因在牙齒生長(zhǎng)發(fā)育中表達(dá),其中BMPs、FGFs、Shh和Wnt信號(hào)分子家族的 

【文章來(lái)源】：四川醫(yī)學(xué). 2020,41(06)

【文章頁(yè)數(shù)】：9 頁(yè)

【文章目錄】：
1 牙齒的發(fā)育過程
2 牙齒發(fā)育潛能的轉(zhuǎn)移
3 牙源性干細(xì)胞
4 干細(xì)胞牙向分化分子調(diào)控機(jī)制
    4.1 BMPs信號(hào)通路
    4.2 BMPs信號(hào)通路與牙齒發(fā)育的關(guān)系
    4.3 FGFs信號(hào)通路
    4.4 FGFs信號(hào)通路與牙齒發(fā)育的關(guān)系
    4.5 Shh信號(hào)通路
    4.6 Shh信號(hào)通路與牙齒發(fā)育的關(guān)系
    4.7 Wnt信號(hào)通路
    4.8 Wnt信號(hào)通路與牙齒發(fā)育的關(guān)系


【參考文獻(xiàn)】：
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[3]Smad4在人牙胚發(fā)育各期的表達(dá)與分布[J]. 何文喜,牛忠英,趙守亮,陳健.  北京口腔醫(yī)學(xué). 2001(01)



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