前言顱頜面骨骼的修復(fù)因其解剖結(jié)構(gòu)復(fù)雜,又毗鄰眾多重要組織,且由于顱頜面部是個(gè)人身份識(shí)別的重要標(biāo)志,有著不可或缺的社交功能,對(duì)于個(gè)體生活質(zhì)量有著巨大的影響,顱頜面骨骼的修復(fù)對(duì)精度有著極高的要求。顱頜面骨骼修復(fù)的目標(biāo)是要同時(shí)恢復(fù)其美觀和功能,這就需要精準(zhǔn)的術(shù)前設(shè)計(jì)和術(shù)中虛擬設(shè)計(jì)方案的轉(zhuǎn)化應(yīng)用。顱頜面骨骼修復(fù)的金標(biāo)準(zhǔn)是自體骨移植。然而,由于自體骨移植后骨骼供區(qū)的不適、供區(qū)取骨加術(shù)中雕刻導(dǎo)致手術(shù)時(shí)間過長(zhǎng),術(shù)后感染風(fēng)險(xiǎn)頗高、且無(wú)法用于修復(fù)過大的骨骼缺損等原因,自體骨移植的應(yīng)用受到了頗多限制。因此人工骨材料的研究在顱頜面修復(fù)領(lǐng)域愈發(fā)得到關(guān)注。新一代的人工骨材料為可塑性醫(yī)用樹脂和羥基磷灰石（epoxide acrylate maleic andhydroxyapatite,EH）微粒,該材料具有良好的生物相容性、炎性反應(yīng)小、允許宿主組織長(zhǎng)入且吸收量有限;但缺點(diǎn)是材質(zhì)較脆,術(shù)中難以塑形。自20世紀(jì)90年代以來,快速成型技術(shù)和計(jì)算機(jī)輔助技術(shù)的快速發(fā)展,使得它已然成為醫(yī)療領(lǐng)域的新寵。過去的十年中,三維打印技術(shù)（一種快速成型技術(shù)）被廣泛應(yīng)用于定制個(gè)性化的手術(shù)工具、導(dǎo)向裝置和內(nèi)植物等�？焖俪尚图夹g(shù)（rapid... 

【文章來源】：上海交通大學(xué)上海市 211工程院校 985工程院校 教育部直屬院校

【文章頁(yè)數(shù)】：100 頁(yè)

【學(xué)位級(jí)別】：碩士

【文章目錄】：
中文摘要
Abstract Ⅰ
摘要 Ⅰ
Abstract Ⅱ
摘要 Ⅱ
Introduction
PART Ⅰ APPLICATION OF THREE DIMENSIONAL PRINTING TECHNOLOGY BASED ARTIFICIAL BONE IMPLANT IN REPAIR OF MANDIBULAR ASYMMETRICAL DEFORMITY
    1.1.Introduction
    1.2.Aim
    1.3.Methods
        1.3.1.Preoperative planning
            1.3.1.1.Collection of Computed tomographic data
            1.3.1.2.Virtual personalized three dimensional model design
            1.3.1.3.Manufacturing of customized patients specific implants
        1.3.2.Surgical procedures
        1.3.3.Postoperative evaluations
        1.3.4.Statistical analysis
    1.4.Results
    1.5.Discussion
    1.6.Conclusion
    1.7.Limitation
    1.8.Future prospective
PART Ⅱ EVALUATION OF CLINICAL OUTCOMES OF 3D PRINTING GUIDES COMBINE WITH NAVIGATION TECHNIQUE IN REDUCTION OF ZOM COMPLEX FRACTURE
    2.1.Introduction
    2.2.Aim
    2.3.Methods
        2.3.1.Patients selection
        2.3.2.Preoperation
            2.3.2.1. CT scan and three dimensional reconstruction
            2.3.2.2. Virtual Surgical Plan
        2.3.3.Intra-operation
            2.3.3.1. Surgical procedures
        2.3.4.Postoperative management and evaluation
        2.3.5.Statistical analysis
    2.4.Results
        2.4.1.Demographic characteristics
        2.4.2.Unoverlapped volumes percentage and mean deviation between virtualplan and postoperative CT
        2.4.3.Clinical assessment of diplopia severity and clinical assessment of mouthopening and other outcomes
    2.5. Discussion
    2.6. Conclusion
    2.7. Limitation
    2.8. Future prospective
General Conclusion
Bibliography
Acknowledgement
Appendix-Paper
List of Publications



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