【摘要】：目的:探討妊娠期牙周炎對產(chǎn)婦母嬰結(jié)局的影響及其作用機(jī)制。方法:選取行口腔檢查的90例孕婦(孕32~38周)為研究對象,根據(jù)檢查結(jié)果分為牙周炎30例,牙齦炎30例以及牙周正常孕婦30例。根據(jù)新生兒出生體重分為體重正常組56例和低出生體重組34例,根據(jù)分娩孕周分為足月產(chǎn)組62例以及早產(chǎn)兒組28例。采用ELISA法測定孕婦牙齦溝液、唾液及血清中IL-1β,IL-8水平。結(jié)果:牙周炎組新生兒出生體重、分娩孕周顯著小于牙齦炎組及牙周正常組,而早產(chǎn)兒及低出生體重兒出生率高于牙齦炎組及牙周正常組(P0.05)。牙周炎組牙齦溝液、唾液IL-1β、IL-8水平顯著高于牙齦炎及牙周正常組(P0.05)。早產(chǎn)兒組血清中IL-1β、IL-8水平顯著高于足月兒組,低出生體重兒血清中IL-1β、IL-8水平顯著高于體重出生正常組(P0.05)。經(jīng)Pearson相關(guān)性分析可知,3組齦溝液中IL-1β、IL-8水平與唾液中IL-1β、IL-8水平有統(tǒng)計學(xué)相關(guān)性(P0.05),而齦溝液中IL-1β、IL-8水平與血液中IL-1β、IL-8水平無相關(guān)性(P0.05)。結(jié)論:牙周炎孕婦齦溝液、唾液及血清中IL-1β、IL-8水平升高可能與低出生體重兒及早產(chǎn)兒等不良妊娠結(jié)局有關(guān)。
[Abstract]:Objective: to investigate the effect of periodontitis during pregnancy on maternal and infant outcome and its mechanism. Methods: 90 pregnant women (32 weeks gestation for 38 weeks) were selected as subjects. According to the results, 30 cases of periodontitis, 30 cases of gum inflammation and 30 cases of normal periodontitis were divided into three groups: periodontitis (30 cases), gum inflammation (30 cases) and normal periodontal pregnant women (30 cases). According to the birth weight of neonates, they were divided into normal weight group (n = 56) and low birth weight group (n = 34), full-term delivery group (n = 62) and premature infants group (n = 28). The levels of IL-1 尾 and IL-8 in gum sulcus fluid, saliva and serum of pregnant women were measured by ELISA. Results: the birth weight and gestational age of neonates in periodontitis group were significantly lower than those in gingivitis group and normal periodontal group, while the birth rate of premature infants and low birth weight infants was higher than that of gingivitis group and normal periodontal group (P 0.05). The levels of IL-1 尾 and IL-8 in gum crevicular fluid and saliva in periodontitis group were significantly higher than those in gingivitis group and normal periodontal group (P 0.05). The levels of serum IL-1 尾 and IL-8 in premature infants were significantly higher than those in term infants, and the levels of IL-1 尾 and IL-8 in low birth weight infants were significantly higher than those in normal birth weight group (P 0.05). The results of Pearson correlation analysis showed that the levels of IL-1 尾 and IL-8 in gingival crevicular fluid were significantly correlated with the levels of IL-1 尾 and IL-8 in saliva (P 0.05), but the levels of IL-1 尾 and IL-8 in gingival crevicular fluid were not correlated with the levels of IL-1 尾 and IL-8 in blood (P 0.05). Conclusion: the increased levels of IL-1 尾 and IL-8 in gum crevicular fluid, saliva and serum of pregnant women with periodontitis may be related to the adverse pregnancy outcomes of low birth weight infants and premature infants.
【作者單位】： 山東省濟(jì)南市第三人民醫(yī)院產(chǎn)科;
【分類號】：R714.25;R781.42

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