【摘要】：背景:患有骨質(zhì)疏松的老年無牙頜患者剩余牙槽嵴往往形態(tài)不佳,修復難度較大,目前尚無相應參考指標來反映此類患者剩余牙槽嵴吸收的情況和指示重襯等臨床處理的頻率。目的:分析患有骨質(zhì)疏松的老年無牙頜患者全口義齒重襯頻率與血清中骨鈣素和Ⅰ型膠原羧基端交聯(lián)肽兩種骨轉(zhuǎn)化標志物水平之間的相關(guān)性,以期為臨床全口義齒修復提供參考。方法:按照納入標準隨機選取50例已行全口義齒修復并患有骨質(zhì)疏松的老年無牙頜患者,對其進行相關(guān)問卷調(diào)查并查閱病史確定義齒重襯頻率,同時采集患者空腹靜脈血,采用電化學發(fā)光免疫法測量血清中骨鈣素與Ⅰ型膠原羧基端交聯(lián)肽的水平,通過Pearson相關(guān)性檢驗的統(tǒng)計學方法來分析重襯頻率與骨鈣素和Ⅰ型膠原羧基端交聯(lián)肽之間的關(guān)系。結(jié)果與結(jié)論:患者的義齒重襯頻率與血清中骨鈣素水平之間有顯著的正相關(guān)關(guān)系(r=0.517,P0.01),而其與血清中Ⅰ型膠原羧基端交聯(lián)肽水平并未觀察到顯著相關(guān)性(r=0.278,P=0.0510.05),但二者有著相近的變化趨勢。說明對于患有骨質(zhì)疏松的老年無牙頜患者來說,檢測血清中骨轉(zhuǎn)化標志物水平有助于全口義齒修復療效預后的評估和診療決策的制定。
[Abstract]:Background: the residual alveolar ridge in elderly edentulous patients with osteoporosis is often poor in shape and difficult to repair. At present, there are no corresponding reference indexes to reflect the absorption of residual alveolar ridge and the frequency of clinical treatment such as heavy lining. Objective: to analyze the correlation between the frequency of complete denture alignment and the level of serum osteocalcin and type I collagen carboxy terminal crosslinked peptide in elderly edentulous jaw patients with osteoporosis. In order to provide reference for clinical complete denture repair. Methods: according to the inclusion criteria, 50 elderly edentulous jaw patients who had undergone complete denture restoration and osteoporosis were randomly selected and investigated by questionnaire, and the frequency of denture heavy lining was determined by consulting the medical history. At the same time, fasting venous blood was collected. The levels of osteocalcin and type I collagen carboxy terminal crosslinked peptide in serum were measured by electrochemiluminescence immunoassay. The relationship between recontrast frequency and osteocalcin and type I collagen carboxy terminal crosslinked peptide was analyzed by Pearson correlation test. Results and conclusion: there was a significant positive correlation between the frequency of denture realignment and the level of osteocalcin in serum (r 鈮，

本文編號：2480701