【摘要】：目的:分析復發(fā)性阿弗他潰瘍(RAU)發(fā)病與焦慮情緒之間的關系,對比RAU患者和對照組唾液中皮質(zhì)醇含量、脫氫表雄酮(DHEA)含量、皮質(zhì)醇/DHEA比值,并進一步探討RAU患者焦慮情況與唾液皮質(zhì)醇水平、DHEA水平以及皮質(zhì)醇/DHEA比值的相關性,選擇出能夠在臨床上評估焦慮與RAU關系的重要指標。方法:選取30例于佳木斯大學附屬口腔醫(yī)院牙周黏膜病科就診并診斷為輕型RAU的患者作為實驗組。另外納入同期在佳木斯大學附屬口腔醫(yī)院體檢科檢查顯示口腔黏膜健康的30名健康人為對照組。在上午8-10點之間對每個受試者進行唾液樣本的收集,并采用醫(yī)院焦慮抑郁量表焦慮分表(HAD-A)分別評定每個受試對象的焦慮水平,收集的唾液樣本置于-80℃的冰箱中存放,實驗前將其置于室溫融化,離心后去掉沉渣,采用酶聯(lián)免疫吸附法(ELISA)對兩組受試者唾液中的皮質(zhì)醇水平和DHEA水平進行測定,并計算皮質(zhì)醇/DHEA的比值,通過統(tǒng)計學比較每組對象的焦慮情況、唾液皮質(zhì)醇水平、唾液DHEA水平以及唾液皮質(zhì)醇/DHEA比值的差異,并分析RAU患者焦慮與唾液皮質(zhì)醇、DHEA水平以及二者之間比值的相關性。結(jié)果:1統(tǒng)計學分析顯示,RAU組焦慮得分為10.53±3.73,對照組焦慮得分為5.47±3.56,差異具有統(tǒng)計學意義(P0.05)。RAU組唾液皮質(zhì)醇的水平是39.58±8.76ug/L,明顯高于對照組的19.84±6.94 ug/L,差異具有統(tǒng)計學意義(P0.01)。RAU組的唾液DHEA水平為38.08±11.96 nmol/L,雖低于對照組的49.36±12.05 nmol/L,但差異并無統(tǒng)計學意義(P0.05)。RAU組的皮質(zhì)醇/DHEA比值是1.20±0.64,顯然比對照組的0.43±0.21要高,差異具有統(tǒng)計學意義(P0.05)。2 Pearson相關性分析發(fā)現(xiàn),RAU實驗組的焦慮得分與唾液皮質(zhì)醇水平具有一定的相關性,且為正相關,相關系數(shù)r=0.685,P0.01。RAU組的焦慮得分與皮質(zhì)醇/DHEA的比值也具有高度相關性,且為正相關,相關系數(shù)r=0.641,P0.01。結(jié)論:1 RAU的發(fā)生與焦慮情緒有關。2 RAU患者唾液皮質(zhì)醇水平相對升高,唾液DHEA水平無明顯變化,皮質(zhì)醇/DHEA比值也相對升高。3 RAU患者焦慮水平與唾液中皮質(zhì)醇水平以及皮質(zhì)醇/DHEA比值有一定的相關性,臨床上可以通過檢測唾液中皮質(zhì)醇的含量以及皮質(zhì)醇/DHEA的比值來評估RAU發(fā)病與焦慮的關系。
[Abstract]:Objective: to analyze the relationship between (RAU) and anxiety in recurrent aphthous ulcer, and to compare the levels of cortisol, dehydroepiandrosterone (DHEA), cortisol / DHEA in saliva of RAU patients and controls. Furthermore, the relationship between anxiety and salivary cortisol level, DHEA level and cortisol / DHEA ratio in patients with RAU was further investigated, and an important index to evaluate the relationship between anxiety and RAU was selected. Methods: thirty patients with mild RAU were selected from periodontal mucosal disease department of Stomatology Hospital affiliated to Jiamusi University as experimental group. In addition, 30 healthy persons who were examined in the Department of physical examination of Stomatology Hospital affiliated to Jiamusi University in the same period were taken as control group. Saliva samples were collected from 8 to 10 a.m. and the anxiety level of each subject was assessed by the Hospital anxiety and Depression scale anxiety scale (HAD-A). The collected saliva samples were stored in a refrigerator at -80 鈩，

本文編號：2369004