種植體周?chē)l溝液中SOD、GP-x、MDA水平的初步研究
發(fā)布時(shí)間：2018-07-27 14:36
【摘要】：種植義齒修復(fù)在臨床上運(yùn)用越來(lái)越廣泛，然而種植體并發(fā)癥會(huì)降低種植體的成功率，導(dǎo)致種植體的最終失敗，其中種植體周?chē)资欠N植體最常見(jiàn)的并發(fā)癥之一，，如何預(yù)防和早期診斷種植體周?chē)资悄壳柏酱鉀Q的問(wèn)題。大量研究認(rèn)為牙周炎的發(fā)生與氧化應(yīng)激反應(yīng)相關(guān)，種植體周?chē)缀脱乐苎子兄嗨频牟∫蚣芭R床癥狀，因此，研究種植體周?chē)椎陌l(fā)生與氧化應(yīng)激是否存在一定相關(guān)性對(duì)于臨床上早期診斷和治療種植體周?chē)锥加兄匾饬x。 鈷鉻合金烤瓷是臨床上最常見(jiàn)的冠修復(fù)材料之一，但一些研究指出烤瓷熔附金屬全冠的金屬基底會(huì)游離出金屬離子，對(duì)牙周健康造成一定影響，氧化鋯全瓷因其良好的美觀性，舒適性和生物相容性，逐漸成為臨床上常用的口腔修復(fù)材料，但因?yàn)閮r(jià)格較高限制了患者的選擇。因此，我們擬比較兩種冠修復(fù)材料對(duì)種植體周?chē)M織的影響，為臨床上如何選擇種植體上部修復(fù)材料提供參考依據(jù)。 目的： 1.通過(guò)比較種植體和天然牙齦溝液的量、牙周臨床指標(biāo)及齦溝液中SOD、GP-x、MDA、IL-1β水平，探討種植體周?chē)M織的健康狀況與局部氧化應(yīng)激的關(guān)系，為如何預(yù)防、早期診斷和治療種植體周?chē)滋峁├碚摶A(chǔ)。 2.通過(guò)檢測(cè)鈷鉻合金烤瓷全冠和氧化鋯全瓷冠修復(fù)種植體上部結(jié)構(gòu)后的齦溝液的量、牙周臨床指標(biāo)及齦溝液中SOD、GP-x、MDA、IL-1β水平，探討這兩種冠修復(fù)材料對(duì)種植體周?chē)M織的影響，為臨床上種植體上部結(jié)構(gòu)全冠修復(fù)材料的選擇提供一定的理論依據(jù)。 方法： 1.納入96位患者，種植體修復(fù)牙位121個(gè)，天然牙牙位121個(gè)。分組：分為健康種植體組（98例）、種植體周?chē)つぱ捉M（23例）和健康天然牙對(duì)照組（121例）；對(duì)患者的菌斑指數(shù)、齦溝出血指數(shù)、探診深度、齦溝液的量及齦溝液中SOD、GP-x、MDA、IL-1β水平進(jìn)行檢測(cè)。齦溝液量的檢測(cè)采用吸潮紙尖稱(chēng)重法；SOD、GP-x、MDA、IL-1β水平檢測(cè)運(yùn)用雙抗體夾心ELISA方法。 2.納入96位患者，其中有121個(gè)種植體牙位（健康的種植體98例，種植體周?chē)つぱ捉M23例）。其中鈷鉻合金金屬烤瓷全冠修復(fù)69個(gè)種植體牙位，氧化鋯全瓷冠修復(fù)52個(gè)種植體牙位。分組：A組為鈷鉻合金烤瓷全冠修復(fù)后種植體周健康者（56例）；B組為氧化鋯全瓷冠修復(fù)后種植體周健康者（42例）；C組為鈷鉻合金烤瓷全冠修復(fù)后種植體周?chē)つぱ渍撸?3例）；D組為氧化鋯全瓷冠修復(fù)后種植體周?chē)つぱ渍撸?0例）。對(duì)患者的菌斑指數(shù)、齦溝出血指數(shù)、探診深度、齦溝液的量及齦溝液中SOD、GP-x、MDA、IL-1β水平進(jìn)行檢測(cè)。齦溝液量的檢測(cè)采用吸潮紙尖稱(chēng)重法，SOD、GP-x、MDA、IL-1β水平檢測(cè)運(yùn)用雙抗體夾心ELISA方法。 結(jié)果： 1.健康種植體與健康天然牙的GCF的量、PLI、SBI、PD指標(biāo)的比較，差異無(wú)統(tǒng)計(jì)學(xué)意義（P＞0.05）。 2.健康種植體組SOD、GP-x、MDA、IL-1β水平稍高于對(duì)照組，差異無(wú)統(tǒng)計(jì)學(xué)意義（P＞0.05）。 3.種植體周?chē)つぱ捉MGCF的量及PLI、SBI、PD指標(biāo)、MDA、IL-1β水平均高于對(duì)照組和健康種植體組，SOD、GP-x水平低于對(duì)照組和健康種植體組，差異具有統(tǒng)計(jì)學(xué)意義（P＜0.05或P＜0.01）。 4.A組與B組、C組與D組之間GCF的量及PLI、SBI、PD指標(biāo)、SOD、GP-x、MDA、IL-lβ水平的比較，差異無(wú)統(tǒng)計(jì)學(xué)意義（P＞0.05）。 5.A組和C組、B組和D組間GCF的量及PLI、SBI、PD指標(biāo)、SOD、GP-x、MDA、IL-lβ水平的比較，GCF的量及PLI、SBI、PD指標(biāo)、IL-lβ、MDA水平A組低于C組，B組低于D組；SOD、GP-x水平A組高于C組，B組高于D組，差異具有統(tǒng)計(jì)學(xué)意義（P＜0.01）。 結(jié)論： 1.種植體植入后種植體周局部微環(huán)境存在輕度的氧化應(yīng)激反應(yīng)。 2.種植體周?chē)つぱ椎陌l(fā)生與局部的氧化應(yīng)激反應(yīng)具有一定相關(guān)性，但是否存在因果關(guān)系還需進(jìn)一步研究證實(shí)。 3.種植體上部結(jié)構(gòu)兩種全冠修復(fù)材料與種植體周?chē)つぱ椎陌l(fā)病無(wú)明顯相關(guān)性。
[Abstract]:Implant prosthesis is becoming more and more widely used in clinical practice. However, implant complications will reduce the success rate of implants and lead to the final failure of implants. The periimplant inflammation is one of the most common complications of implant. How to prevent and early diagnosis of periimplant inflammation is a problem to be solved urgently. The occurrence of periodontitis is associated with oxidative stress. Periodermatitis and periodontitis have similar causes and clinical symptoms. Therefore, the study of whether there is a certain correlation between the occurrence of peri implant inflammation and oxidative stress is of great significance in the early diagnosis and treatment of periimplant inflammation.
Cobalt chromium alloy porcelain is one of the most common restorative materials in the clinic. However, some studies have pointed out that the metal substrate of the metal full crown of the porcelain fused to metal ions can be dissociated from metal ions and has a certain influence on the periodontal health. The zirconia all porcelain has gradually become a commonly used dental restorative material because of its good beauty, comfort and biocompatibility. But because the price is high, the patient's choice is limited. Therefore, we should compare the effect of two kinds of crown restorations on the tissue around the implant, and provide a reference for how to choose the upper prosthesis of the implant.
Objective:
1. by comparing the amount of implant and natural gingival crevicular fluid, periodontal clinical indicators and SOD, GP-x, MDA, and IL-1 beta levels in gingival crevicular fluid, the relationship between the health of the tissue around the implant and the local oxidative stress was explored to provide a theoretical basis for the prevention and early diagnosis and treatment of periimplant inflammation.
2. by detecting the amount of gingival crevicular fluid, periodontal clinical indexes and SOD, GP-x, MDA, IL-1 beta levels in gingival crevicular fluid, the effects of the two kinds of crown restorations on the surrounding tissue of the implant were investigated by detecting the total crown of cobalt chromium alloy porcelain fused to the superstructure of the implant and the effect of the two kinds of crown restorations on the tissue around the implant. A certain theoretical basis.
Method:
1. were included in 96 patients, 121 dental implants and 121 dental teeth. Groups were divided into healthy implant group (98 cases), periimplant mucositis group (23 cases) and healthy natural tooth control group (121 cases). The plaque index, gingival gingival bleeding index, depth of gingival crevicular fluid, SOD, GP-x, MDA, IL-1 beta in gingival crevicular fluid of the patients were measured. The detection of gingival crevicular fluid was performed by the method of weighing the moisture absorbing paper tip. The SOD, GP-x, MDA and IL-1 beta levels were detected by the double antibody sandwich ELISA method.
2. of the 96 patients were treated with 121 dental implants (98 healthy implants and 23 cases of periimplant mucositis), of which 69 implant teeth were repaired with cobalt chromium alloy metal crown, and 52 dental implants were repaired with zirconia full porcelain crown. Group A was a healthy person (56) with CO Cr alloy porcelain crown restoration (56 cases); B The group was 42 cases of periodontal health after the restoration of zirconia full porcelain crown (42 cases), and the group of 13 cases of periimplant mucositis after the restoration of cobalt chromium alloy porcelain fused to porcelain crown (13 cases), and the group of 10 cases of periimplant mucositis after the restoration of zirconium oxide fully porcelain crown (10 cases). The plaque index, gingival gingival bleeding index, the depth of the gingival crevicular fluid and the SO in the gingival crevicular fluid The levels of D, GP-x, MDA and IL-1 beta were detected. The gingival crevicular fluid volume was measured by the moisture absorption paper tip weighing method, SOD, GP-x, MDA and IL-1 beta levels detected by double antibody sandwich ELISA method.
Result:
1. there was no significant difference in GCF, PLI, SBI and PD between healthy implants and healthy natural teeth (P > 0.05).
2. the SOD, GP-x, MDA and IL-1 beta levels in the healthy implant group were slightly higher than those in the control group, and the difference was not statistically significant (P > 0.05).
3. the amount of GCF and the level of PLI, SBI, PD, MDA and IL-1 beta in the periimplant mucositis group were higher than those in the control group and the healthy implant group. The level of SOD and GP-x was lower than that of the control group and the healthy implants (P < 0.05 or P < 0.01).
There was no significant difference in GCF, PLI, SBI, PD, SOD, GP-x, MDA, and beta level between group 4.A and group B and group C (D > 0.05).
The amount of GCF between group 5.A and group C, group B and D, PLI, SBI, PD index, SOD, GP-x, MDA, and IL-l beta level are lower than those of the group.
Conclusion:
1. there was mild oxidative stress in the local microenvironment after implant placement.
2. there is a certain correlation between the occurrence of periprosthetic mucositis and local oxidative stress, but whether there is a causal relationship needs further studies to confirm.
3. there was no significant correlation between the two kinds of crown restoration materials and the incidence of perigraft mucositis.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R783.4
本文編號(hào)：2148135
[Abstract]:Implant prosthesis is becoming more and more widely used in clinical practice. However, implant complications will reduce the success rate of implants and lead to the final failure of implants. The periimplant inflammation is one of the most common complications of implant. How to prevent and early diagnosis of periimplant inflammation is a problem to be solved urgently. The occurrence of periodontitis is associated with oxidative stress. Periodermatitis and periodontitis have similar causes and clinical symptoms. Therefore, the study of whether there is a certain correlation between the occurrence of peri implant inflammation and oxidative stress is of great significance in the early diagnosis and treatment of periimplant inflammation.
Cobalt chromium alloy porcelain is one of the most common restorative materials in the clinic. However, some studies have pointed out that the metal substrate of the metal full crown of the porcelain fused to metal ions can be dissociated from metal ions and has a certain influence on the periodontal health. The zirconia all porcelain has gradually become a commonly used dental restorative material because of its good beauty, comfort and biocompatibility. But because the price is high, the patient's choice is limited. Therefore, we should compare the effect of two kinds of crown restorations on the tissue around the implant, and provide a reference for how to choose the upper prosthesis of the implant.
Objective:
1. by comparing the amount of implant and natural gingival crevicular fluid, periodontal clinical indicators and SOD, GP-x, MDA, and IL-1 beta levels in gingival crevicular fluid, the relationship between the health of the tissue around the implant and the local oxidative stress was explored to provide a theoretical basis for the prevention and early diagnosis and treatment of periimplant inflammation.
2. by detecting the amount of gingival crevicular fluid, periodontal clinical indexes and SOD, GP-x, MDA, IL-1 beta levels in gingival crevicular fluid, the effects of the two kinds of crown restorations on the surrounding tissue of the implant were investigated by detecting the total crown of cobalt chromium alloy porcelain fused to the superstructure of the implant and the effect of the two kinds of crown restorations on the tissue around the implant. A certain theoretical basis.
Method:
1. were included in 96 patients, 121 dental implants and 121 dental teeth. Groups were divided into healthy implant group (98 cases), periimplant mucositis group (23 cases) and healthy natural tooth control group (121 cases). The plaque index, gingival gingival bleeding index, depth of gingival crevicular fluid, SOD, GP-x, MDA, IL-1 beta in gingival crevicular fluid of the patients were measured. The detection of gingival crevicular fluid was performed by the method of weighing the moisture absorbing paper tip. The SOD, GP-x, MDA and IL-1 beta levels were detected by the double antibody sandwich ELISA method.
2. of the 96 patients were treated with 121 dental implants (98 healthy implants and 23 cases of periimplant mucositis), of which 69 implant teeth were repaired with cobalt chromium alloy metal crown, and 52 dental implants were repaired with zirconia full porcelain crown. Group A was a healthy person (56) with CO Cr alloy porcelain crown restoration (56 cases); B The group was 42 cases of periodontal health after the restoration of zirconia full porcelain crown (42 cases), and the group of 13 cases of periimplant mucositis after the restoration of cobalt chromium alloy porcelain fused to porcelain crown (13 cases), and the group of 10 cases of periimplant mucositis after the restoration of zirconium oxide fully porcelain crown (10 cases). The plaque index, gingival gingival bleeding index, the depth of the gingival crevicular fluid and the SO in the gingival crevicular fluid The levels of D, GP-x, MDA and IL-1 beta were detected. The gingival crevicular fluid volume was measured by the moisture absorption paper tip weighing method, SOD, GP-x, MDA and IL-1 beta levels detected by double antibody sandwich ELISA method.
Result:
1. there was no significant difference in GCF, PLI, SBI and PD between healthy implants and healthy natural teeth (P > 0.05).
2. the SOD, GP-x, MDA and IL-1 beta levels in the healthy implant group were slightly higher than those in the control group, and the difference was not statistically significant (P > 0.05).
3. the amount of GCF and the level of PLI, SBI, PD, MDA and IL-1 beta in the periimplant mucositis group were higher than those in the control group and the healthy implant group. The level of SOD and GP-x was lower than that of the control group and the healthy implants (P < 0.05 or P < 0.01).
There was no significant difference in GCF, PLI, SBI, PD, SOD, GP-x, MDA, and beta level between group 4.A and group B and group C (D > 0.05).
The amount of GCF between group 5.A and group C, group B and D, PLI, SBI, PD index, SOD, GP-x, MDA, and IL-l beta level are lower than those of the group.
Conclusion:
1. there was mild oxidative stress in the local microenvironment after implant placement.
2. there is a certain correlation between the occurrence of periprosthetic mucositis and local oxidative stress, but whether there is a causal relationship needs further studies to confirm.
3. there was no significant correlation between the two kinds of crown restoration materials and the incidence of perigraft mucositis.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R783.4
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