本文選題：髁突 + 骨折�。� 參考：《重慶醫(yī)學》2015年16期

【摘要】：目的研究髁突在體內(nèi)受異常應力變化后對髁突軟骨超微結(jié)構(gòu)的影響。方法采用4周齡SD大鼠54只建立髁突頸骨折及截骨模型,設截骨組、骨折組及空白對照組,于術(shù)后1、3、5周處死,光鏡、掃描電鏡(SEM)及透射電鏡(TEM)觀察髁突軟骨結(jié)構(gòu)變化。結(jié)果光鏡顯示術(shù)后3、5周,截骨組及骨折組髁突總厚度均小于空白對照組。SEM顯示截骨組和骨折組術(shù)后5周膠原纖維暴露,截骨組手術(shù)側(cè)還出現(xiàn)膠原纖維斷裂、崩解。TEM顯示術(shù)后3周截骨組較空白對照組及骨折組肥大軟骨細胞成熟分化增強;截骨組術(shù)后1周手術(shù)側(cè)可見表面纖維排列紊亂甚至缺失。5周截骨組手術(shù)側(cè)見膠原纖維排列更為紊亂,纖維層中可見到裂隙。結(jié)論體內(nèi)髁突異常應力變化會持續(xù)影響髁突軟骨超微結(jié)構(gòu)變化,且跟應力變化的程度相關(guān),進而引起髁突發(fā)育的異常。
[Abstract]:Objective to study the effect of condyle on the ultrastructure of condylar cartilage after abnormal stress changes in vivo. Methods 54 SD rats aged 4 weeks were used to establish condylar neck fracture and osteotomy model. Osteotomy group, fracture group and blank control group were sacrificed at 1 and 3 weeks after operation. The changes of condylar cartilage structure were observed by light microscope, scanning electron microscope (SEM) and transmission electron microscope (TEM). Results the total thickness of condylar process in osteotomy group and fracture group was less than that in control group. SEM showed collagen fiber exposure in osteotomy group and fracture group 5 weeks after operation. The maturation and differentiation of mast chondrocytes in osteotomy group were stronger than those in control group and fracture group 3 weeks after operation. In the osteotomy group, the surface fibers were disordered at the first week after operation, even at the loss of 5 weeks. In the osteotomy group, the collagenous fibers were more disordered, and cracks could be seen in the fibrous layer. Conclusion the change of condylar abnormal stress in vivo will continuously affect the ultrastructural changes of condylar cartilage, which is related to the degree of stress change, and then cause the abnormal development of condyle.
【作者單位】： 昆明醫(yī)科大學口腔醫(yī)學院;云南文山州醫(yī)院口腔科;江蘇省無錫市第三人民醫(yī)院口腔科;
【基金】：國家自然科學基金面上項目(30960426,81360163) 云南省科技廳-昆明醫(yī)科大學應用基礎聯(lián)合專項資金項目(2013FZ279)
【分類號】：R782.4

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