本文選題：牙周病　切入點(diǎn)：基質(zhì)金屬蛋白酶　出處：《中國(guó)老年學(xué)雜志》2017年12期 　論文類型：期刊論文

【摘要】：目的探討牙周病大鼠牙組織中基質(zhì)金屬蛋白酶(MMP)-9表達(dá)與牙根吸收程度的關(guān)系。方法 12周齡健康雄性Wistar大鼠40只隨機(jī)分為對(duì)照組和實(shí)驗(yàn)組,各20只。對(duì)照組僅給予正畸處理,實(shí)驗(yàn)組先建立牙周病模型,再給予正畸處理。分別于正畸牽拉前、牽拉1、2、4 w觀察兩組大鼠根尖吸收情況和牙組織MMP-9的表達(dá)情況。結(jié)果正畸牽拉前,兩組大鼠均未見明顯的根尖吸收情況;牽拉1 w后,兩組大鼠均可見明顯根尖吸收;在牽拉后2 w時(shí),對(duì)照組根尖吸收活動(dòng)基本停止,實(shí)驗(yàn)組繼續(xù)增加,至4 w時(shí)基本停止。牽拉前,實(shí)驗(yàn)組的MMP-9陽性染色光密度值顯著高于對(duì)照組(P0.05);牽拉后,兩組大鼠的陽性染色光密度值均顯著升高,對(duì)照組在牽拉后2 w開始下降,實(shí)驗(yàn)組在牽拉后4 w開始下降。兩組大鼠的MMP-9陽性染色光密度值變化趨勢(shì)與根尖吸收活動(dòng)趨勢(shì)基本一致,且實(shí)驗(yàn)組的光密度值顯著高于對(duì)照組(P0.05)。結(jié)論牙周病大鼠牙組織中MMP-9的表達(dá)水平與牙根吸收活動(dòng)的變化趨勢(shì)基本一致,可作為判斷牙根吸收的生物標(biāo)志物之一。
[Abstract]:Objective to study the expression of matrix metal in rat periodontal disease periodontal tissue protease (MMP) the relationship between the -9 expression and the extent of root resorption. Methods 12 week old healthy male Wistar 40 rats were randomly divided into control group and experimental group, 20 rats in each. The control group only received orthodontic treatment, the experimental group to establish a model of periodontal disease then, given orthodontic treatment. In orthodontic traction, traction pull 1,2,4 w expression was observed in the two groups of rats MMP-9 and root resorption of periodontal tissue. The results of orthodontic traction, two groups of rats showed no obvious root resorption; stretch after 1 W, two groups of rats were root resorption; after pulling in 2 W, the control group root resorption activity basically stopped, the experimental group continued to increase to 4 W. Stop pulling, the experimental group MMP-9 positive staining optical density value is significantly higher than the control group (P0.05); after pulling, the two groups of rats were dyed the density values were significant With the increase in the control group after pulling 2 W began to decline, in the experimental group decreased after pulling 4 W. The two groups of rats MMP-9 staining optical density change trend and root resorption activity trend is basically the same, and optical density value of the experimental group was significantly higher than the control group (P0.05) and the expression level. The root tissue of rat tooth MMP-9 conclusion periodontal disease in the absorption change trend of activities are basically the same, can be used to determine the root resorption biomarkers.

【作者單位】： 皖南醫(yī)學(xué)院口腔醫(yī)學(xué)院;
【分類號(hào)】：R783.5

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6 徐s，

本文編號(hào)：1604947