本文選題：牙再移術(shù)　切入點(diǎn)：樹突細(xì)胞　出處：《重慶醫(yī)學(xué)》2014年26期 　論文類型：期刊論文

【摘要】：目的探討不同來(lái)源致耐受樹突細(xì)胞(DC)對(duì)大鼠同種異體牙移植后牙根吸收及愈合的影響。方法用BN、Lewis大鼠分別作為供、受體建立動(dòng)物實(shí)驗(yàn)?zāi)Ｐ?采用完全隨機(jī)法分為4組,每組20只:A為同基因移植;B、C、D為同種異體移植;A、B組于術(shù)前7d給大鼠輸注PBS緩沖液0.5mL,C、D組于術(shù)前7d分別給大鼠輸注1×106個(gè)/只的供、受體致耐受DC。各組于術(shù)后第1、2、4、8周隨機(jī)處死5只大鼠,進(jìn)行移植牙病理學(xué)檢查。結(jié)果炎性細(xì)胞浸潤(rùn)B組最重,A組最輕,C、D介于二者之間。牙根吸收A組最少,B組最多,C、D介于二者之間(P0.05);2、4周時(shí)牙根吸收C、D組差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),在8周時(shí)D組低于C組(P0.05)。第8周時(shí)牙周膜愈合點(diǎn)數(shù)C、D組少于A組,多于B組(P0.05);炎性吸收B組最高(P0.05);替代吸收A組最低(P0.05)。結(jié)論兩種不同來(lái)源的致耐受DC都可以降低牙移植的排斥反應(yīng),減少牙根的吸收,促進(jìn)牙周膜的愈合;其受體致耐受DC更能減少牙根后期的吸收。
[Abstract]:Objective to investigate the effects of tolerance dendritic cells (DCCs) from different sources on root resorption and healing after allogeneic tooth transplantation in rats. In each group, 20 rats were given PBS buffer 0.5 mL per rat 7 days before operation. Each group was injected with 1 脳 10 6 / rat on 7 days before operation to induce tolerance to DC.The rats in each group were randomly killed at the 1248th week after operation, and 5 rats were randomly killed at the 1248th week after operation, and the rats in each group were injected with 0.5 mL of PBS buffer respectively on the 7th day before operation to induce tolerance to DC.The rats were randomly killed in each group at the 1248 weeks after operation, and the rats were injected with 0.5 mL of PBS buffer respectively on the 7th day before operation. Results pathological examination of transplanted teeth was performed. Results in group B, inflammatory cell infiltration was found to be between the most severe group and group A, while in group A, the lowest density of Con D in group B was between the two groups. There was no significant difference between group A and group B in root resorption of cad at 4 weeks after 4 weeks of dental root resorption. The number of periodontal ligament healing points in group C was lower than that in group A at 8 weeks, and the number of healing points in group C was lower than that in group A at week 8. It was more than group B (P 0.05), inflammatory absorption group B (P 0.05) was the highest, and group A was the lowest absorbent group (P 0.05). Conclusion two kinds of tolerant DC from different sources can reduce the rejection of tooth transplantation, reduce the root absorption and promote the healing of periodontal ligament. The receptor-tolerant DC can reduce the late root resorption.
【作者單位】： 重慶醫(yī)科大學(xué)附屬永川醫(yī)院口腔科;重慶醫(yī)科大學(xué)附屬口腔醫(yī)院正畸科;
【基金】：重慶市教育委員會(huì)科學(xué)技術(shù)研究項(xiàng)目(KJ100302)
【分類號(hào)】：R782;R392.4

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