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  本文關(guān)鍵詞： 皰疹病毒 侵襲性牙周炎 Meta分析　出處：《山東大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：.研究證實皰疹病毒的檢出率與侵襲性牙周炎的發(fā)病及嚴(yán)重程度有關(guān)系,然而由于檢測人群、取樣方法以及檢測方法的差異,此種聯(lián)系仍然存在爭議。本課題擬通過總結(jié)現(xiàn)有的病例對照研究,探索皰疹病毒與侵襲性牙周炎之間的關(guān)系。方法：計算機(jī)檢索Pubmed、Embase、中國知網(wǎng)(CNKI)、萬方數(shù)據(jù)知識服務(wù)平臺以及維普期刊資源整合服務(wù)平臺,全面系統(tǒng)的收集對比皰疹病毒與侵襲性牙周炎關(guān)系的病例對照研究。檢索時間截止至2015年10月。按照Cochrane系統(tǒng)評價方法,2位評價者獨立使用納入標(biāo)準(zhǔn)篩選文獻(xiàn)、提取數(shù)據(jù)。運(yùn)用Revman及STATA軟件完成數(shù)據(jù)的綜合與處理。結(jié)果：與對照組相比,人巨細(xì)胞病毒(Human cytomegalovirus, HCMV)和單純皰疹病毒1型(Herpes simplex virus 1, HSV-1)均與侵襲性牙周炎顯示出明顯的相關(guān)性(HCMV共納入13項研究,p0.0001, OR= 5.37,95% CI=2.35-12.26; HSV-1共納入4項研究,p0.001, OR=20.99,95% CI=8.52-51.73),敏感性分析證實兩項結(jié)果穩(wěn)定可靠,Begg's等級相關(guān)測試(Begg's rank correlation test)及Egger's漏斗圖對稱性測試(Egger's funnel plot asymmetry test)證實無明顯的發(fā)表偏倚。EB病毒(Epstein-Barr virus, EBV)同樣顯示出與侵襲性牙周炎較高的相關(guān)性(共納入10項研究,p=0.001, OR=5.43,95% CI=1.94-15.22),敏感性分析證實結(jié)果穩(wěn)定,但是同時存在一定的發(fā)表偏倚。結(jié)論：綜合現(xiàn)有的研究證據(jù),HCMV和HSV-1的檢出率與侵襲性牙周炎顯示出明顯的相關(guān)性。
[Abstract]:Objective\\\. The relationship between herpesvirus and invasive periodontitis was explored by summarizing the existing case-control studies. Methods: Pubmeda Embase was searched by computer. CNKI, Wanfang data knowledge Service platform and Weipu periodical Resource Integration Service platform. A comprehensive and systematic case-control study was conducted to compare the relationship between herpes virus and invasive periodontitis. The search time was up to October 2015. According to the evaluation method of Cochrane system. Two evaluators independently used inclusion criteria to screen literature and extract data. Revman and STATA software were used to complete the data synthesis and processing. Results: compared with the control group. Human cytomegalovirus (simplex) and herpes simplex virus type 1 (Herpes simplex virus 1). HSV-1) showed significant correlation with invasive periodontitis. HCMV was included in 13 studies (P 0.0001, OR = 5.37). 95% CI 2.35-12.26; HSV-1 included 4 studies (p 0.001), ORG 20.99% CI 8.52-51.73. Sensitivity analysis confirmed that the two results were stable and reliable. Begg's grade correlation test (Beggs rank correlation test) and Egger's funnel symmetry test (. Egger's funnel plot asymmetry test confirmed that there was no obvious publication bias. Epstein-Barr virus. EBV also showed a high correlation with invasive periodontitis (including 10 studies, p0.001, ORV 5.43 95% CI 1.94-15.22). Sensitivity analysis confirmed that the results were stable, but there was a certain degree of publication bias. Conclusion: the detection rate of HCMV and HSV-1 is significantly correlated with invasive periodontitis.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R781.42

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