本文關(guān)鍵詞：臨床頸部淋巴結(jié)陰性舌鱗癌中腫瘤轉(zhuǎn)移相關(guān)因子1的表達(dá)及與病理分級(jí)的關(guān)系　出處：《廣東醫(yī)學(xué)》2016年10期 　論文類(lèi)型：期刊論文

  更多相關(guān)文章： 舌鱗狀細(xì)胞癌 MTA蛋白 量子點(diǎn)熒光探針

【摘要】：目的應(yīng)用量子點(diǎn)熒光探針檢測(cè)臨床頸部淋巴結(jié)陰性(c N0)舌鱗癌組織中腫瘤轉(zhuǎn)移相關(guān)因子1(MTA1)蛋白的表達(dá)強(qiáng)度,探討MTA1的表達(dá)與舌鱗癌組織病理分級(jí)的相關(guān)性。方法量子點(diǎn)熒光探針及免疫組化染色法檢測(cè)48例舌鱗癌標(biāo)本MTA1在鱗癌組織及癌周?chē)＝M織中的表達(dá),同時(shí)按照組織病理分級(jí)分組比較各組間MTA1蛋白表達(dá)強(qiáng)度的差異。結(jié)果量子點(diǎn)熒光探針檢測(cè)MTA1蛋白在高分化(Ⅰ級(jí))、中分化(Ⅱ級(jí))及低分化(Ⅲ級(jí))組中的陽(yáng)性表達(dá)率分別為42.1%、73.3%、85.7%,各組間差異有統(tǒng)計(jì)學(xué)意義(P0.05);免疫組化染色檢測(cè)MTA1蛋白在3組中的陽(yáng)性表達(dá)率分別為36.8%、66.7%、78.6%,各組間差異有統(tǒng)計(jì)學(xué)意義(P0.05),即分化程度越低,其陽(yáng)性表達(dá)率越高。結(jié)論 MTA1蛋白表達(dá)強(qiáng)度與c N_0舌鱗癌病理分化程度關(guān)系密切,MTA1蛋白可能在c N0舌鱗癌的局部浸潤(rùn)生長(zhǎng)中起重要作用。
[Abstract]:Objective to detect the expression of tumor metastasis associated factor 1 (MTA1) protein in cervical lymph node negative tongue squamous cell carcinoma (LSCC) by using quantum dot fluorescence probe (QDFS). To investigate the correlation between the expression of MTA1 and the pathological grade of tongue squamous cell carcinoma. Methods the expression of MTA1 in 48 cases of tongue squamous cell carcinoma and its surrounding normal tissues were detected by quantum dot fluorescence probe and immunohistochemical staining. Expression. At the same time, the expression intensity of MTA1 protein was compared according to histopathological grading. Results Quantum Dot fluorescence probe was used to detect the expression of MTA1 protein in high differentiation (grade 鈪，

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