本文關鍵詞：臨床頸部淋巴結陰性舌鱗癌中腫瘤轉移相關因子1的表達及與病理分級的關系　出處：《廣東醫(yī)學》2016年10期 　論文類型：期刊論文

  更多相關文章： 舌鱗狀細胞癌 MTA蛋白 量子點熒光探針

【摘要】：目的應用量子點熒光探針檢測臨床頸部淋巴結陰性(c N0)舌鱗癌組織中腫瘤轉移相關因子1(MTA1)蛋白的表達強度,探討MTA1的表達與舌鱗癌組織病理分級的相關性。方法量子點熒光探針及免疫組化染色法檢測48例舌鱗癌標本MTA1在鱗癌組織及癌周圍正常組織中的表達,同時按照組織病理分級分組比較各組間MTA1蛋白表達強度的差異。結果量子點熒光探針檢測MTA1蛋白在高分化(Ⅰ級)、中分化(Ⅱ級)及低分化(Ⅲ級)組中的陽性表達率分別為42.1%、73.3%、85.7%,各組間差異有統(tǒng)計學意義(P0.05);免疫組化染色檢測MTA1蛋白在3組中的陽性表達率分別為36.8%、66.7%、78.6%,各組間差異有統(tǒng)計學意義(P0.05),即分化程度越低,其陽性表達率越高。結論 MTA1蛋白表達強度與c N_0舌鱗癌病理分化程度關系密切,MTA1蛋白可能在c N0舌鱗癌的局部浸潤生長中起重要作用。
[Abstract]:Objective to detect the expression of tumor metastasis associated factor 1 (MTA1) protein in cervical lymph node negative tongue squamous cell carcinoma (LSCC) by using quantum dot fluorescence probe (QDFS). To investigate the correlation between the expression of MTA1 and the pathological grade of tongue squamous cell carcinoma. Methods the expression of MTA1 in 48 cases of tongue squamous cell carcinoma and its surrounding normal tissues were detected by quantum dot fluorescence probe and immunohistochemical staining. Expression. At the same time, the expression intensity of MTA1 protein was compared according to histopathological grading. Results Quantum Dot fluorescence probe was used to detect the expression of MTA1 protein in high differentiation (grade 鈪，

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