發(fā)布時(shí)間：2019-07-11 08:10

【摘要】：目的探討老年人應(yīng)用抗抑郁藥的安全性,為老年人合理使用抗抑郁藥提供參考。方法回顧性分析2012年1月至2013年12月北京協(xié)和醫(yī)院院老年示范病房77例65歲以上患者的抗抑郁藥物的使用情況、起始劑量及不良反應(yīng)。結(jié)果經(jīng)老年醫(yī)學(xué)跨學(xué)科團(tuán)隊(duì)會(huì)診,77例均服用新型抗抑郁藥,其中舍曲林使用率最高,對(duì)低體重指數(shù)患者更多選擇米氮平治療,伴有慢性疼痛的患者中50%使用5-羥色胺和(或)去甲腎上腺素再攝取抑制劑。70例住院后開(kāi)始抗抑郁藥治療,72.8%的患者初始給藥量從小劑量開(kāi)始,不良反應(yīng)發(fā)生率為8.6%(6/70)。結(jié)論應(yīng)結(jié)合老年患者特點(diǎn),以及抗抑郁藥的特點(diǎn)、不良反應(yīng)和藥物之間的相互作用來(lái)選擇適當(dāng)?shù)目挂钟羲幬铩?br/>[Abstract]:Objective to explore the safety of antidepressants in the elderly and to provide reference for the rational use of antidepressants in the elderly. Methods from January 2012 to December 2013, the use, initial dose and adverse reactions of antidepressants in 77 patients over 65 years old in the demonstration ward of Peking Union Medical College Hospital were analyzed retrospectively. Results after interdisciplinary team consultation of geriatrics, 77 cases were treated with new antidepressants, among which sertralin was the most frequently used. 50% of patients with chronic pain were treated with sertraline and / or norepinephrine reuptake inhibitor. 70 patients began antidepressant treatment after hospitalization, and 72.8% of patients began to take antidepressants at a low dose. The incidence of adverse reactions was 8.6% (6 鈮，

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