氟西汀與艾司西酞普蘭對老年抑郁癥外周血免疫T淋巴細胞亞群的影響
發(fā)布時間：2019-06-26 23:09
【摘要】：目的:考察氟西汀與艾司西酞普蘭對老年抑郁癥外周血免疫T淋巴細胞亞群的影響差異及療效比較。方法:收集2010年4月-2013年6月就診的原發(fā)性抑郁癥患者89例,隨機分為氟西汀組42例和艾司西酞普蘭組47例,同期收集健康體檢老年人49例作為對照。結果:與健康對照組比,2個組別的CD3、CD4和CD8降低(P0.05),CD4/CD8增高(P0.05),治療前2個組別的外周血T淋巴細胞亞群無顯著差異(P0.05),治療后,2個組別的CD3、CD4和CD8升高(P0.05),CD4/CD8降低(P0.05),與氟西汀組比,艾司西酞普蘭組的CD4/CD8顯著降低(P0.05)。2個組別治療前漢密爾頓抑郁量表(HAMD)評分無顯著差異,2組治療后各時段均下降明顯,與治療前比較有顯著性差異(P0.05)。艾司西酞普蘭組第1,2,4,8周的HAMD評分均低于氟西汀組,2組有顯著性差異(P0.05)。2個組別的療效和不良反應無顯著差異(P0.05)。結論:艾司西酞普蘭和氟西汀均可通過提高和調(diào)節(jié)T淋巴細胞的功能,以增強老年抑郁患者的免疫功能,艾司西酞普蘭增加老年抑郁患者的免疫功能較氟西汀強。
[Abstract]:Objective: to investigate the effect of fluoxetine and escitalopram on peripheral blood immune T lymphocyte subsets in elderly patients with depression. Methods: 89 patients with primary depression from April 2010 to June 2013 were randomly divided into fluoxetine group (n = 42) and escitalopram group (n = 47). At the same time, 49 elderly patients were collected as control. Results: compared with the healthy control group, CD3,CD4 and CD8 decreased (P 0.05) and CD4/CD8 increased (P 0.05) in the two groups. There was no significant difference in peripheral blood T lymphocyte subsets between the two groups before treatment (P 0.05). After treatment, CD3,CD4 and CD8 increased (P 0.05) and CD4/CD8 decreased (P 0.05) in the two groups, compared with fluoxetine group. There was no significant difference in the (HAMD) score of Hamilton depression scale between the two groups before treatment, but there was significant difference between the two groups at all time points after treatment, which was significantly different from that before treatment (P 0.05). The HAMD scores of escitalopram group were lower than those of fluoxetine group at the 1st, 2nd and 4th week, and there was significant difference between the two groups (P 0.05). There was no significant difference in the curative effect and adverse reactions between the two groups (P 0.05). Conclusion: escitalopram and fluoxetine can enhance the immune function of elderly patients with depression by improving and regulating the function of T lymphocytes. Escitalopram can increase the immune function of elderly patients with depression than fluoxetine.
【作者單位】： 齊齊哈爾醫(yī)學院精神衛(wèi)生學院;齊齊哈爾市第一醫(yī)院;
【分類號】：R749.4
[Abstract]:Objective: to investigate the effect of fluoxetine and escitalopram on peripheral blood immune T lymphocyte subsets in elderly patients with depression. Methods: 89 patients with primary depression from April 2010 to June 2013 were randomly divided into fluoxetine group (n = 42) and escitalopram group (n = 47). At the same time, 49 elderly patients were collected as control. Results: compared with the healthy control group, CD3,CD4 and CD8 decreased (P 0.05) and CD4/CD8 increased (P 0.05) in the two groups. There was no significant difference in peripheral blood T lymphocyte subsets between the two groups before treatment (P 0.05). After treatment, CD3,CD4 and CD8 increased (P 0.05) and CD4/CD8 decreased (P 0.05) in the two groups, compared with fluoxetine group. There was no significant difference in the (HAMD) score of Hamilton depression scale between the two groups before treatment, but there was significant difference between the two groups at all time points after treatment, which was significantly different from that before treatment (P 0.05). The HAMD scores of escitalopram group were lower than those of fluoxetine group at the 1st, 2nd and 4th week, and there was significant difference between the two groups (P 0.05). There was no significant difference in the curative effect and adverse reactions between the two groups (P 0.05). Conclusion: escitalopram and fluoxetine can enhance the immune function of elderly patients with depression by improving and regulating the function of T lymphocytes. Escitalopram can increase the immune function of elderly patients with depression than fluoxetine.
【作者單位】： 齊齊哈爾醫(yī)學院精神衛(wèi)生學院;齊齊哈爾市第一醫(yī)院;
【分類號】：R749.4
【參考文獻】
相關期刊論文 前10條
1 董繼承;王s，
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