【摘要】：目的比較艾司西酞普蘭與氟西汀治療老年抑郁癥的療效。方法對(duì)艾司西酞普蘭與氟兩汀治療老年抑郁癥對(duì)照研究進(jìn)行系統(tǒng)評(píng)價(jià),應(yīng)用循證醫(yī)學(xué)的研究方法,使用專用的統(tǒng)計(jì)分析軟件Revman 5.1進(jìn)行Meta分析。結(jié)果 7篇隨機(jī)對(duì)照研究滿足納入標(biāo)準(zhǔn)。Meta分析的結(jié)果顯示,療程為1、2、4 w時(shí),兩組漢密爾頓抑郁量表(HAMD)評(píng)分差異無統(tǒng)計(jì)學(xué)意義(Z=0.71、0.21、1.2,P=0.48、0.83、0.20),此時(shí)艾司西酞普蘭與氟西汀療效相當(dāng);療程為6 w時(shí),兩組HAMD評(píng)分差異有統(tǒng)計(jì)學(xué)意義(Z=2.13,P=0.03),此時(shí)艾司西酞普蘭療效優(yōu)于氟西汀。比較療程6 w結(jié)束后的有效率,其OR值為1.51(95%CI:0.93~2.45),兩組之間有效率相當(dāng)(Z=1.65,P=0.10)。比較療程6 w結(jié)束后的痊愈率,其中OR值為1.17(95%CI:0.84~1.63),兩組之間痊愈率相當(dāng)(Z=0.93,P=0.35)。比較療程6 w結(jié)束后的不良反應(yīng),其中OR值為0.86(95%CI:0.53~1.39),兩組之間出現(xiàn)的不良反應(yīng)無差異(Z=0.61,P=0.54)。結(jié)論艾司西酞普蘭用于治療老年抑郁癥是一種安全有效的抗抑郁藥物,且艾司西酞普蘭較氟西汀能夠更好地改善老年抑郁癥癥狀。
[Abstract]:Objective to compare the efficacy of escitalopram and fluoxetine in the treatment of elderly depression. Methods the comparative study of escitalopram and fluodipine in the treatment of elderly depression was systematically evaluated. Meta analysis was carried out by using evidence-based medicine (EBM) and the special statistical analysis software Revman 5.1. Results the results of meta-analysis showed that there was no significant difference in (HAMD) score between the two groups when the course of treatment was 1, 2, 4 weeks (Z 鈮，

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