【摘要】：目的：本研究將利用功能磁共振成像（functional magnetic resonanceimaging,fMRI）技術(shù)探討遺忘型輕度認(rèn)知障礙（Amnestic mild cognitiveimpairment，aMCI）患者靜息態(tài)腦活動(dòng)神經(jīng)網(wǎng)絡(luò)結(jié)構(gòu)和功能特點(diǎn)，幫助我們盡早識(shí)別aMCI，為其防治提供最佳時(shí)間窗；同時(shí)，對(duì)于全面了解大腦功能活動(dòng)具有重要的意義。 方法：本研究于2010年9月至2011年12月期間應(yīng)用神經(jīng)心理評(píng)估量表在門診及住院部篩選出aMCI患者10名、正常老年人10名。利用3.0T磁共振對(duì)受試者進(jìn)行靜息態(tài)fMRI檢查，利用相關(guān)軟件對(duì)受試者影像資料進(jìn)行腦功能網(wǎng)絡(luò)局部一致性（regional homogeneity,ReHo)分析，比較aMCI患者與正常老年人在靜息態(tài)下大腦活動(dòng)差異。 結(jié)果：正常老年人與aMCI患者ReHo分析顯示：扣帶回后部皮層、額葉內(nèi)側(cè)、前額葉內(nèi)側(cè)皮層和頂葉部分區(qū)域的ReHo均顯著增高。aMCI患者ReHo與正常老年人相比，，aMCI患者左側(cè)顳葉（顳中回、顳下回）、左側(cè)海馬旁回、枕葉、舌回、楔前葉等區(qū)域的ReHo降低，而右側(cè)額葉(額下回)、左顳上回、中央前回（額葉）、右側(cè)丘腦、左側(cè)梭狀回等區(qū)域的ReHo增高。 結(jié)論：在靜息狀態(tài)下，正常老年人與aMCI患者扣帶回后部皮層、額葉內(nèi)側(cè)、前額葉內(nèi)側(cè)皮層和頂葉部分區(qū)域局部一致性顯著增高，說明了人腦在靜息狀態(tài)下仍存在著一個(gè)自發(fā)活動(dòng)的默認(rèn)網(wǎng)絡(luò)，這一結(jié)果與既往默認(rèn)功能網(wǎng)絡(luò)的研究一致。aMCI患者靜息狀態(tài)下較正常老年人ReHo增高及減低的區(qū)域提示該組人群的默認(rèn)網(wǎng)絡(luò)存在功能異常，為早期診斷aMCI提供理論和實(shí)驗(yàn)依據(jù)，在一定程度上對(duì)指導(dǎo)個(gè)體治療和預(yù)測(cè)預(yù)后提供幫助。
[Abstract]:Objective: to investigate the structure and functional characteristics of resting brain activity neural network in patients with amnesia mild cognitive impairment (Amnestic mild cognitiveimpairment,aMCI) by functional magnetic resonance imaging (functional magnetic resonanceimaging,fMRI), so as to help us identify aMCI, as soon as possible and provide the best time window for its prevention and treatment. At the same time, it is of great significance for comprehensive understanding of brain function. Methods: from September 2010 to December 2011, 10 patients with aMCI and 10 normal elderly were selected by neuropsychological assessment scale. The resting state fMRI of the subjects was examined by 3.0T magnetic resonance imaging, and the local consistency (regional homogeneity,ReHo) of brain function network was analyzed by using the relevant software to compare the difference of brain activity between aMCI patients and normal elderly people in resting state. Results: ReHo analysis of normal elderly and aMCI patients showed that ReHo in posterior cingulate gyrus, medial frontalis, medial prefrontalis and parietal lobe were significantly higher. Compared with normal elderly, ReHo in patients with AMCI decreased ReHo in left temporal lobe (middle temporal gyrus, infratemporal gyrus), left perihippocampal gyrus, occipital lobe, lingual gyrus, anterior cuneiform lobe and so on, while right frontolobe (inferior frontalis gyrus), left superior temporal gyrus and anterior central gyrus (frontolobe). ReHo increased in the right thalamus and left fusiform gyrus. Conclusion: in resting state, the local consistency of posterior cingulate cortex, medial frontalis, medial prefrontalis cortex and part of parietal lobe between normal elderly and aMCI patients is significantly increased, which indicates that there is still a default network of spontaneous activity in the human brain at rest. This result is consistent with the previous study of default functional network. The increase and decrease of ReHo in patients with AMCI at rest suggest that the default network in this group has abnormal function, which provides theoretical and experimental basis for early diagnosis of aMCI, and to a certain extent is helpful to guide individual treatment and predict prognosis.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R749.16

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 黃覺斌,張振馨;輕度認(rèn)知障礙的現(xiàn)代概念和研究進(jìn)展[J];中華神經(jīng)科雜志;2002年06期

2 白靜,王蔭華,翁旭初,謝晟;輕度認(rèn)知障礙患者計(jì)算能力的fMRI研究[J];中國康復(fù)理論與實(shí)踐;2003年05期

3 周衛(wèi)東,賈建平;血漿血紅素加氧酶1測(cè)定在輕度認(rèn)知障礙和老年性癡呆中的臨床意義[J];中國神經(jīng)精神疾病雜志;2004年04期

4 熊光潤,陳靜,王虹敏,顧昱,熊芳琴,馮玲,譚曉敏,王靜;輕度認(rèn)知障礙患者情感圖片再認(rèn)的研究[J];神經(jīng)疾病與精神衛(wèi)生;2004年03期

5 周愛紅,王蔭華,周曉林;輕度阿爾茨海默病患者和輕度認(rèn)知功能障礙患者注意功能的研究(英文)[J];中國臨床康復(fù);2005年05期

6 王學(xué)美;富宏;劉庚信;朱偉;李娌;楊金霞;;從氧化損傷探討加味五子衍宗顆粒對(duì)輕度認(rèn)知障礙患者的影響[J];中國中西醫(yī)結(jié)合雜志;2008年01期

7 李剛;;老年認(rèn)知障礙的流行性與嚴(yán)重性[J];國外醫(yī)學(xué).老年醫(yī)學(xué)分冊(cè);1998年04期

8 戴曉w

本文編號(hào)：2505085