【摘要】：目的觀察當(dāng)飛利肝寧片治療精神病藥物所致肝功能損傷的療效。方法將服用抗精神病藥物導(dǎo)致輕度肝功能損傷的80例住院精神病患者隨機(jī)分為當(dāng)飛利肝寧片治療組(治療組,40例)和護(hù)肝片治療組(對(duì)照組,40例),治療組口服當(dāng)飛利肝寧片,每次2片,每天3次;對(duì)照組口服護(hù)肝片,每次4片,每天3次,兩組均治療4周。觀察治療前及治療1、2、4周后ALT、AST變化情況,比較兩組療效。結(jié)果與本組前一時(shí)間點(diǎn)比較,兩組治療1、2、4周ALT、AST逐漸降低(P0.05)。治療組治愈率、總有效率分別為72.5%、97.5%,對(duì)照組治愈率、總有效率分別為62.5%、90.0%,兩組治愈率及總有效率差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。兩組均未出現(xiàn)明顯不良反應(yīng)。結(jié)論當(dāng)飛利肝寧片可以安全有效地治療抗精神病藥物所致肝功能損傷。
[Abstract]:Objective to observe the efficacy of Dangfei Liganning tablets in the treatment of liver function injury caused by psychotic drugs. Methods 80 inpatients with mild liver function injury caused by antipsychotic drugs were randomly divided into treatment group (n = 40) and Hugan tablet treatment group (n = 40). The treatment group was treated with Dangfeili Ganning tablets, 2 tablets at a time, 3 times a day. The control group took oral Hugan tablets, 4 tablets at a time, 3 times a day, both groups were treated for 4 weeks. The changes of ALT,AST were observed before treatment and 1, 2 weeks after treatment, and the curative effects of the two groups were compared. Results compared with the previous time point, the ALT,AST of the two groups decreased gradually at 1, 2 and 4 weeks (P 0.05). The cure rate and total effective rate were 72.5% and 97.5% in the treatment group and 62.5% and 90.0% in the control group, respectively. there was no significant difference in the cure rate and the total effective rate between the two groups (P 0.05). There were no obvious adverse reactions in both groups. Conclusion Dangfei Ganning tablets can safely and effectively treat liver function damage caused by antipsychotic drugs.
【作者單位】： 浙江省臺(tái)州醫(yī)院感染科;浙江省臺(tái)州市第二人民醫(yī)院精神科;
【分類(lèi)號(hào)】：R575.3;R749.3

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