【摘要】：背景：性激素在健康人群的視空間認(rèn)知能力中具有重要意義，特別是睪酮被發(fā)現(xiàn)與視空間認(rèn)知能力密切相關(guān)。已經(jīng)有研究者嘗試揭示精神分裂癥患者的睪酮水平與心理旋轉(zhuǎn)任務(wù)期間腦激活的關(guān)系，并且報告了精神分裂癥男性患者在心理旋轉(zhuǎn)表現(xiàn)上的缺陷與腦功能活動的紊亂。分裂型人格障礙(Schizotypal PersonalityDisorder, SPD)是通過與精神分裂癥的遺傳學(xué)關(guān)系而定義的一種人格障礙。本次研究以分裂型人格障礙者為對象，期待可以進(jìn)一步認(rèn)識分裂型人格障礙患者是否存在視空間能力的缺陷，試圖揭示睪酮對精神分裂癥譜系障礙的視空間能力影響的神經(jīng)基質(zhì)。 目標(biāo)：1、檢測分裂型人格障礙男性青年在視空間能力任務(wù)的表現(xiàn)，以及與視空間能力有關(guān)的腦區(qū)域的激活情況。2、試圖探索睪酮與分裂型人格障礙男性青年的視空間能力之間的相關(guān)，并檢驗分裂型人格障礙男性青年的血清睪酮水平與心理旋轉(zhuǎn)期間的腦區(qū)域激活之間的相關(guān)。 方法：17名分裂型人格障礙青年男性作為研究對象，以及17名健康青年男性作為對照組，參與了此次研究。抽取被試肘靜脈血，用于血清睪酮水平的測量。對所有被試實施一個紙筆版的心理旋轉(zhuǎn)能力測驗(MRT-A, Peters et al.,1995)，測量被試的視空間能力。采用3.0Tesla核磁共振掃描成像系統(tǒng)對所有被試進(jìn)行掃描，使用E-prime軟件呈現(xiàn)刺激圖片（經(jīng)典三維積木圖形），旋轉(zhuǎn)任務(wù)與非旋轉(zhuǎn)條件交替呈現(xiàn)。使用SPM8軟件對功能性核磁共振成像的數(shù)據(jù)進(jìn)行處理，并對感興趣區(qū)域進(jìn)行相關(guān)分析。 結(jié)果：1、分裂型人格障礙組青年男性的血清睪酮水平顯著高于健康對照組。2、在心理旋轉(zhuǎn)測驗的表現(xiàn)上，分裂型人格障礙組與對照組得分沒有顯著差異。3、心理旋轉(zhuǎn)條件與非旋轉(zhuǎn)條件相比較：SPD組在頂下小葉、楔前葉、額中回、額下回、額內(nèi)側(cè)回、小腦后葉、小腦前葉、丘腦的激活顯著增多，，對照組在楔前葉、頂下小葉、額中回、額下回、小腦前葉、島葉、丘腦激活顯著增多。4、心理旋轉(zhuǎn)任務(wù)的激活差異：與對照組相比，SPD組在額上回、額中回、額下回以及顳葉顯示出更多的激活，然而與SPD組相比，對照組在顳葉、扣帶回和島葉表現(xiàn)出更多的激活。5、在SPD組，睪酮水平與額中回的激活表現(xiàn)出顯著的正相關(guān)關(guān)系，而在對照組中，睪酮與腦激活之間沒有表現(xiàn)出相關(guān)關(guān)系。 結(jié)論：本次實驗結(jié)果進(jìn)一步確認(rèn)了心理旋轉(zhuǎn)任務(wù)的激活模式。與健康青年男性的腦激活模式相比，分裂型人格障礙青年男性的腦激活模式表現(xiàn)出顯著不同。分裂型人格障礙青年男性睪酮水平顯著高于正常青年男性，并且其睪酮水平與額中回激活強(qiáng)度相關(guān)。這些結(jié)果說明了分裂型人格障礙青年男性在空間能力任務(wù)中腦功能活動的改變，并且睪酮可能在這些腦功能活動的變化中起到介導(dǎo)作用。
[Abstract]:Background: sex hormones play an important role in visual spatial cognitive ability of healthy people, especially testosterone is found to be closely related to visual spatial cognitive ability. Some researchers have tried to reveal the relationship between testosterone level and brain activation during the task of psychological rotation, and reported the defects of mental rotation and the disorder of brain function in male patients with schizophrenia. Mitotic personality disorder (Schizotypal PersonalityDisorder, SPD) is a personality disorder defined by its genetic relationship with schizophrenia. In this study, people with mitotic personality disorder are expected to further understand whether there is a defect in visual space ability in patients with mitotic personality disorder. This paper attempts to reveal the neural matrix of the effect of testosterone on the visual space ability of schizophrenia pedigree disorder. Objective: 1. To detect the performance of young men with split personality disorder in the task of visual space ability and the activation of brain areas related to visual space ability. 2, This paper attempts to explore the correlation between testosterone and visual space ability of young men with mitotic personality disorder, and to test the correlation between serum testosterone level and activation of brain region during psychological rotation. Methods: 17 young men with split personality disorder and 17 healthy young men as control group participated in the study. The blood of elbow vein was taken for the measurement of serum testosterone level. A paper-pen psychological rotation ability test (MRT-A, Peters et al.,1995) was performed on all subjects, and the visual space ability of the subjects was measured. 3.0Tesla nuclear magnetic resonance imaging system was used to scan all the subjects. E-prime software was used to present stimulus images (classical three-dimensional building block graphics). The rotation task and non-rotating conditions were presented alternately. SPM8 software was used to process the data of functional magnetic resonance imaging (fMRI), and the correlation analysis of the region of interest was carried out. Results: 1. The serum testosterone level of young men in the split personality disorder group was significantly higher than that in the healthy control group. 2. There was no significant difference in the scores between the split personality disorder group and the control group in the psychological rotation test. The activation of psychological rotation condition was significantly increased in subparietal lobule, anterior cuneiform lobe, middle frontalis gyrus, inferior frontalis gyrus, medial frontalis gyrus, posterior cerebellar lobe, anterior cerebellar lobe and thalamus in SPD group, while in control group, the activation of anterior cuneiform lobe and subparietal lobe was significantly higher than that in control group. Activation of the anterior cerebellar lobe, insular lobe and thalamus increased significantly in the middle forehead gyrus, inferior forehead gyrus, cerebellar anterior lobe, insular lobe and thalamus. 4. The activation difference of psychological rotation task: compared with the control group, the SPD group showed more activation in the superior forehead, middle forehead, inferior forehead and temporal lobe. However, compared with the SPD group, the control group showed more activation in the temporal lobe, cingulate gyrus and insular lobe. 5, in the SPD group, testosterone levels showed a significant positive correlation with the activation of the middle frontalis, while in the control group, There was no correlation between testosterone and brain activation. Conclusion: the results of this experiment further confirm the activation mode of psychological rotation task. Compared with the brain activation mode of healthy young men, the brain activation mode of young men with mitotic personality disorder was significantly different from that of healthy young men. The testosterone level of young men with mitotic personality disorder was significantly higher than that of normal young men, and its testosterone level was correlated with the activation intensity of middle forehead gyrus. These results suggest that young men with split personality disorder have changes in brain function during spatial ability tasks, and testosterone may play a mediating role in these changes in brain function.
【學(xué)位授予單位】：大連醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R749.91

【參考文獻(xiàn)】

相關(guān)期刊論文 前6條

1 劉慧娟,雷平?jīng)_,崔伊薇,胡虞志,張楠;女青少年性激素與身心發(fā)育相互關(guān)系的研究[J];中國兒童保健雜志;1999年01期

2 劉慧娟,張智民,王耀平,楊朝寬,戴能光,路志順;雌二醇和睪酮對女學(xué)生身心發(fā)育的影響[J];河南醫(yī)學(xué)研究;2002年01期

3 劉錦霞;段立暉;吳靜靜;于淼;吳元赭;吳效科;;多囊卵巢綜合征性激素變化與認(rèn)知功能的臨床觀察[J];醫(yī)學(xué)研究生學(xué)報;2008年11期

4 余毅震,周德,崔伊薇;睪酮對男少年身心發(fā)育影響的研究[J];同濟(jì)醫(yī)科大學(xué)學(xué)報;1992年02期

5 李心天;中國人的左右利手分布[J];心理學(xué)報;1983年03期

6 李惠;陳增堂;唐云翔;李春波;肖澤萍;殷芳;王繼軍;;分裂型人格障礙大學(xué)生的社會認(rèn)知功能[J];中國心理衛(wèi)生雜志;2010年04期

本文編號：2487508