【摘要】：目的探討血清S100β與基質(zhì)金屬蛋白酶-9(MMP-9)在糖耐量減低并血管性癡呆患者血清中的表達(dá)及意義。方法選取住院就診的多梗死性癡呆合并糖耐量減低患者共75例,患者分為重、中、低度組,正常健康體檢者25例作為對照組,分別檢測簡易精神狀態(tài)評價量表(MMSE)、S100β和MMP-9,收集數(shù)據(jù)進(jìn)行分析。結(jié)果 S100β在糖耐量減低并血管性癡呆高、中、低組與正常對照組比較差異有統(tǒng)計學(xué)意義(P0.01),S100β與MMSE呈負(fù)相關(guān)(r=-0.921 2,P0.05);MMP-9在糖耐量減低并血管性癡呆重、中、低度患者與正常健康體檢者比較差異有統(tǒng)計學(xué)意義(P0.05,P0.01),MMP-9與MMSE呈負(fù)相關(guān)(r=-0.986 6,P0.05)。結(jié)論糖耐量減低可導(dǎo)致S100β和MMP-9的表達(dá)增加從而誘發(fā)血管性癡呆的產(chǎn)生,血清S100β、MMP-9可能與糖耐量減低并血管性癡呆患者的發(fā)病有關(guān)。
[Abstract]:Objective to investigate the expression and significance of serum S100 尾 and matrix metalloproteinase-9 (MMP-9) in patients with impaired glucose tolerance and vascular dementia. Methods A total of 75 patients with multi-infarct dementia complicated with impaired glucose tolerance were selected. The patients were divided into three groups: severe, moderate, low-grade and normal physical check-up (25 cases) as control group. (MMSE), was measured by mini-mental state assessment scale. S100 尾 and MMP-9, were collected for analysis. Results the levels of S100 尾 in impaired glucose tolerance complicated with vascular dementia were significantly higher than those in control group (P0.01). There was a negative correlation between S100 尾 and MMSE (r = 0.921 2, P0.05). There was a significant difference in MMP-9 between patients with impaired glucose tolerance and vascular dementia (P 0.05, P0.01), and there was a negative correlation between MMP-9 and MMSE (r = 0.986 6, P0.05). Conclusion impaired glucose tolerance can induce vascular dementia by increasing the expression of S100 尾 and MMP-9. Serum S100 尾 and MMP-9 may be related to the pathogenesis of vascular dementia in patients with impaired glucose tolerance.
【作者單位】： 湖北省武漢市第五醫(yī)院神經(jīng)內(nèi)科;
【基金】：武漢市衛(wèi)生局臨床醫(yī)學(xué)科研項目(編號:WX12B04)
【分類號】：R749.13
，

本文編號：2457174