【摘要】：目的觀察氯胺酮在抑郁癥患者無抽搐電休克治療(MECT)中的療效。方法選擇擬行無抽搐電休克治療的抑郁癥患者60例,年齡18~60歲,隨機分為氯胺酮組和丙泊酚組,每組30例。在MECT前靜注阿托品0.5~1.0mg、丙泊酚1.0mg/kg(丙泊酚組)或氯胺酮0.8mg/kg(氯胺酮組),待患者睫毛反射消失后靜注琥珀膽堿0.7~1.0mg/kg。分別在第2、4、6次治療后完成漢密爾頓抑郁量表(HAMD)。記錄患者每次治療時抽搐時間、抽搐指數(shù)、能量百分比、呼吸恢復時間及不良反應(yīng)情況。結(jié)果隨著治療次數(shù)增加兩組HAMD總分均明顯下降(P0.05)。氯胺酮組HAMD總分下降明顯快于丙泊酚組(P0.05)。兩組患者抽搐時間、抽搐指數(shù)、能量百分比、呼吸恢復時間差異均無統(tǒng)計學意義。結(jié)論在抑郁癥患者MECT治療中氯胺酮降低HAMD評分的效果優(yōu)于丙泊酚。
[Abstract]:Objective to observe the efficacy of ketamine in the treatment of (MECT) without convulsive shock. Methods Sixty patients with depression, aged 18 to 60 years, were randomly divided into ketamine group and propofol group (n = 30, each group) without electroconvulsive therapy. The patients were divided into two groups: ketamine group (n = 30) and propofol group (n = 30). Before MECT, atropine 0.5 / 1.0 mg, propofol 1.0mg/kg (propofol group) or ketamine 0.8mg/kg (ketamine group) were injected intravenously. After the eyelash reflex disappeared, intravenous injection of succincholine 0.7 / 1.0 mg / kg 路kg ~ (- 1) was given to the patients by intravenous injection of Atropine, propofol 1.0mg/kg (propofol group) or ketamine 0.8mg/kg (ketamine group). The Hamilton Depression scale (HAMD).) was completed after 2,4 and 6 treatments, respectively. The convulsive time, convulsive index, energy percentage, respiratory recovery time and adverse reaction were recorded at each treatment. Results with the increase of treatment times, the total score of HAMD in both groups decreased significantly (P0.05). The total score of HAMD in ketamine group was significantly lower than that in propofol group (P0.05). There was no significant difference in convulsive time, convulsive index, energy percentage and respiratory recovery time between the two groups. Conclusion ketamine is better than propofol in reducing HAMD score in depression patients with MECT.
【作者單位】： 南京腦科醫(yī)院麻醉科;南京市婦幼保健院麻醉科;南京腦科醫(yī)院精神科;南京中醫(yī)藥大學第二附屬醫(yī)院麻醉科;
【分類號】：R749.4

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