電針療法對網(wǎng)癮患者沖動行為及腦磁共振波譜（MRS）影響的研究
發(fā)布時間：2019-02-18 07:51
【摘要】：目的： 本研究擬運用電針療法為干預(yù)手段,采用磁共振波譜(magnetic resonance spectroscopy, MRS)相關(guān)指標對互聯(lián)網(wǎng)成癮綜合癥(internet addiction disorder, IAD)產(chǎn)生的沖動行為機制做探討,同時利用有關(guān)網(wǎng)癮和沖動特質(zhì)評價量表(barratt impulsivity scale-11, BIS-11)的評分,以及反應(yīng)抑制功能測試任務(wù)(Go/No-go)的完成情況,來了解電針干預(yù)對沖動行為的影響,以期為未來相關(guān)研究提供更為科學客觀的評價體系和全面的治療方案。 方法： 將符合IAD納入標準的32例受試者隨機分成兩組,每組16例,其中脫落2例、剔除1例,實際完成受試為29例。電針組15例,采取電針干預(yù)；心理組14例,采取認知行為療法干預(yù)。分別治療兩個療程。治療前后采用網(wǎng)癮自評量表、BIS-11沖動量表、Go/No-go任務(wù)以及磁共振波譜技術(shù)(MRS)的相關(guān)指標觀察各組沖動行為心理狀態(tài)、反應(yīng)抑制及大腦生化代謝的變化。另招募正常志愿者16例,設(shè)為正常對照組,采集網(wǎng)癮自評量表、BIS-11沖動量表、Go/No-go任務(wù)以及MRS相關(guān)指標對比,觀察正常組與實驗組治療前后在心理狀態(tài)、反應(yīng)抑制及大腦生化代謝變化的差異。 結(jié)果： 1、網(wǎng)絡(luò)癮白評量表顯示無論是電針還是心理行為康復療法都對IAD患者網(wǎng)絡(luò)成癮癥狀、惡劣心境以及精神依賴等心理感受有明顯的改善作用。組間比較差異說明電針在改善IAD心理或精神癥狀上效果更顯著。 2、BIS-11的結(jié)果表明,無論哪種干預(yù)療法,在改善IAD患者的沖動人格特質(zhì)、降低沖動性上都是有效而顯著的,但電針組在改善沖動特質(zhì)的構(gòu)成因素上范圍更廣,且比心理療法更顯著。 3、Go/No-go任務(wù)結(jié)果顯示,行即時針刺后,正常組無論正確率(ACC)還是反應(yīng)時間(RT)均表現(xiàn)出顯著差異(P0.05),說明即時針刺的確可提高反應(yīng)抑制的能力。實驗組在治療前行即時針刺,無論ACC還是RT改變均無顯著差異(P0.05)；經(jīng)過治療后再對這兩組網(wǎng)癮受試者進行即時針刺,盡管完成Go/No-go任務(wù)的正確率(ACC)無顯著變化(P0.05),但反應(yīng)時間(RT)均顯著縮短(P0.05),說明經(jīng)過治療后,網(wǎng)癮患者與反應(yīng)抑制和沖動控制相關(guān)的腦區(qū)功能得到改善,同時執(zhí)行任務(wù)的神經(jīng)通路反應(yīng)敏感性增高,因此對即時針刺的反應(yīng)比治療前表現(xiàn)得更為敏感。 4、MRS結(jié)果顯示電針后NAA/Cr的比值比治療前升高,且差異顯著(P0.05)；而心理組沒有這樣顯著的改變,說明針刺對與沖動行為和反應(yīng)抑制功能相關(guān)的腦區(qū)的生化代謝情況影響更明顯,在兩個療程結(jié)束后可顯著提高腦內(nèi)NAA含量,從一定程度上反應(yīng)了電針治療具有更明顯的腦保護作用。
[Abstract]:Objective: to explore the mechanism of impulsive behavior induced by internet addiction syndrome (internet addiction disorder, IAD) by magnetic resonance spectroscopy (magnetic resonance spectroscopy, MRS) and electroacupuncture therapy (EA). In order to understand the effect of electroacupuncture intervention on impulsive behavior, the scores of Internet addiction and impulsive trait assessment scale (barratt impulsivity scale-11, BIS-11) and the completion of response inhibition function test (Go/No-go) were also used to understand the effect of electroacupuncture intervention on impulsive behavior. In order to provide a more scientific and objective evaluation system and comprehensive treatment plan for future related research. Methods: 32 subjects who met the criteria of IAD were randomly divided into two groups: 16 cases in each group, 2 cases dropped out, 1 case was eliminated, 29 cases were actually completed. 15 cases in electroacupuncture group were treated with electroacupuncture intervention, and 14 cases in psychological group were treated with cognitive behavioral therapy. Two courses of treatment were given respectively. Before and after treatment, the mental state of impulsive behavior, inhibition of reaction and the changes of biochemical metabolism of brain were observed by using self-rating scale of Internet addiction, BIS-11 impulse scale, Go/No-go task and (MRS) of magnetic resonance spectroscopy. In addition, 16 normal volunteers were recruited as normal control group. The self-rating scale of Internet addiction, BIS-11 impulse scale, Go/No-go task and MRS related indexes were collected to observe the psychological status of normal group and experimental group before and after treatment. Differences in response inhibition and changes in brain biochemical metabolism. Results: 1. The results showed that both electroacupuncture and psycho-behavioral rehabilitation therapy could significantly improve the psychological feelings of IAD patients, such as internet addiction symptoms, bad mood and mental dependence. The difference between groups showed that electroacupuncture was more effective in improving psychological or mental symptoms of IAD. The results of BIS-11 showed that either intervention therapy was effective and significant in improving impulsive personality traits and reducing impulsivity in patients with IAD, but the electroacupuncture group had a wider range of factors in improving impulsive traits. And more significant than psychotherapy. 3The results of Go-No-go task showed that the correct rate of (ACC) and the response time (RT) of the normal group were significantly different after immediate acupuncture (P0.05), which indicated that the instant acupuncture could improve the ability of response inhibition. There was no significant difference in the changes of ACC and RT before treatment in the experimental group (P0.05). After treatment, both groups were treated with instant acupuncture. Although the correct rate of Go/No-go task had no significant change in (ACC) (P0.05), the reaction time (RT) was significantly shortened (P0.05). The results showed that after treatment, the function of brain area related to response inhibition and impulse control was improved, and the sensitivity of neural pathway to task was increased, so the response to immediate acupuncture was more sensitive than that before treatment. 4 the results of Mrs showed that the ratio of NAA/Cr after electroacupuncture was higher than that before treatment, and the difference was significant (P0.05). However, there was no significant change in psychological group, indicating that acupuncture had more obvious effect on biochemical metabolism of brain regions related to impulsive behavior and response inhibition function, and could significantly increase the content of NAA in brain after two courses of treatment. To a certain extent, electroacupuncture therapy has more obvious brain protection.
【學位授予單位】：成都中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2013
【分類號】：R454.1;R749.99
本文編號：2425632
[Abstract]:Objective: to explore the mechanism of impulsive behavior induced by internet addiction syndrome (internet addiction disorder, IAD) by magnetic resonance spectroscopy (magnetic resonance spectroscopy, MRS) and electroacupuncture therapy (EA). In order to understand the effect of electroacupuncture intervention on impulsive behavior, the scores of Internet addiction and impulsive trait assessment scale (barratt impulsivity scale-11, BIS-11) and the completion of response inhibition function test (Go/No-go) were also used to understand the effect of electroacupuncture intervention on impulsive behavior. In order to provide a more scientific and objective evaluation system and comprehensive treatment plan for future related research. Methods: 32 subjects who met the criteria of IAD were randomly divided into two groups: 16 cases in each group, 2 cases dropped out, 1 case was eliminated, 29 cases were actually completed. 15 cases in electroacupuncture group were treated with electroacupuncture intervention, and 14 cases in psychological group were treated with cognitive behavioral therapy. Two courses of treatment were given respectively. Before and after treatment, the mental state of impulsive behavior, inhibition of reaction and the changes of biochemical metabolism of brain were observed by using self-rating scale of Internet addiction, BIS-11 impulse scale, Go/No-go task and (MRS) of magnetic resonance spectroscopy. In addition, 16 normal volunteers were recruited as normal control group. The self-rating scale of Internet addiction, BIS-11 impulse scale, Go/No-go task and MRS related indexes were collected to observe the psychological status of normal group and experimental group before and after treatment. Differences in response inhibition and changes in brain biochemical metabolism. Results: 1. The results showed that both electroacupuncture and psycho-behavioral rehabilitation therapy could significantly improve the psychological feelings of IAD patients, such as internet addiction symptoms, bad mood and mental dependence. The difference between groups showed that electroacupuncture was more effective in improving psychological or mental symptoms of IAD. The results of BIS-11 showed that either intervention therapy was effective and significant in improving impulsive personality traits and reducing impulsivity in patients with IAD, but the electroacupuncture group had a wider range of factors in improving impulsive traits. And more significant than psychotherapy. 3The results of Go-No-go task showed that the correct rate of (ACC) and the response time (RT) of the normal group were significantly different after immediate acupuncture (P0.05), which indicated that the instant acupuncture could improve the ability of response inhibition. There was no significant difference in the changes of ACC and RT before treatment in the experimental group (P0.05). After treatment, both groups were treated with instant acupuncture. Although the correct rate of Go/No-go task had no significant change in (ACC) (P0.05), the reaction time (RT) was significantly shortened (P0.05). The results showed that after treatment, the function of brain area related to response inhibition and impulse control was improved, and the sensitivity of neural pathway to task was increased, so the response to immediate acupuncture was more sensitive than that before treatment. 4 the results of Mrs showed that the ratio of NAA/Cr after electroacupuncture was higher than that before treatment, and the difference was significant (P0.05). However, there was no significant change in psychological group, indicating that acupuncture had more obvious effect on biochemical metabolism of brain regions related to impulsive behavior and response inhibition function, and could significantly increase the content of NAA in brain after two courses of treatment. To a certain extent, electroacupuncture therapy has more obvious brain protection.
【學位授予單位】：成都中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2013
【分類號】：R454.1;R749.99
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