基于體素的形態(tài)測量學(xué)在抑郁癥研究中的應(yīng)用
發(fā)布時間:2019-01-08 08:24
【摘要】:正抑郁癥是情感性精神障礙的主要類型,臨床上以顯著而持久的心境低落為主要特征。目前普遍認(rèn)為抑郁癥患者同時存在腦功能和腦結(jié)構(gòu)的改變,而腦結(jié)構(gòu)改變主要定位于與情感加工有關(guān)的邊緣系統(tǒng)-皮層-紋狀體-蒼白球-丘腦神經(jīng)環(huán)路(limbic-cortical-striatal-pallidal-thalamic,LCSPT);隗w素的形態(tài)測量學(xué)(voxel-based morphometry,VBM)可以對腦結(jié)構(gòu)圖像進(jìn)行全面、自動化分析,通過比較成組受試者高分辨力T1WI結(jié)構(gòu)性影像,獲得全腦組織密度或體積改變的信息[1]。通過對抑郁癥患者的VBM研究有助于揭示抑郁癥的發(fā)生機(jī)制,本文主要就VBM在抑郁癥研究中的應(yīng)用作一綜述,探討此技術(shù)基本原理、方法及優(yōu)缺點(diǎn)。
[Abstract]:Orthodontic depression is the main type of affective disorder, characterized by significant and persistent depression. At present, it is generally believed that there are changes in brain function and brain structure in patients with depression. The changes of brain structure are mainly located in the cortical striatum pallidus colliculus neural loop (limbic-cortical-striatal-pallidal-thalamic,LCSPT) which is related to emotional processing. Morphometry based on voxel (voxel-based morphometry,VBM) can be used to analyze the brain structure image completely and automatically. By comparing the structural images of T1WI with high resolution, we can get the information about the density or volume change of the whole brain tissue [1]. Through the study of VBM in patients with depression, it is helpful to reveal the mechanism of depression. This paper reviews the application of VBM in depression research, and discusses the basic principle, methods, advantages and disadvantages of this technique.
【作者單位】: 南方醫(yī)科大學(xué)珠江醫(yī)院康復(fù)醫(yī)學(xué)科;
【分類號】:R749.4
[Abstract]:Orthodontic depression is the main type of affective disorder, characterized by significant and persistent depression. At present, it is generally believed that there are changes in brain function and brain structure in patients with depression. The changes of brain structure are mainly located in the cortical striatum pallidus colliculus neural loop (limbic-cortical-striatal-pallidal-thalamic,LCSPT) which is related to emotional processing. Morphometry based on voxel (voxel-based morphometry,VBM) can be used to analyze the brain structure image completely and automatically. By comparing the structural images of T1WI with high resolution, we can get the information about the density or volume change of the whole brain tissue [1]. Through the study of VBM in patients with depression, it is helpful to reveal the mechanism of depression. This paper reviews the application of VBM in depression research, and discusses the basic principle, methods, advantages and disadvantages of this technique.
【作者單位】: 南方醫(yī)科大學(xué)珠江醫(yī)院康復(fù)醫(yī)學(xué)科;
【分類號】:R749.4
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