【摘要】：目的觀察復方菖蒲益智顆粒劑口服輔助治療血管性認知功能障礙(VCI)的效果,及其對血清胰島素樣生長因子1(IGF-1)、一氧化氮(NO)和內皮素1(ET-1)水平的影響。方法將102例VCI患者隨機分為觀察組和對照組各51例。兩組均給予西藥口服治療(尼莫地平,奧拉西坦膠囊),觀察組加服復方菖蒲益智顆粒,治療6個月。比較兩組治療前后認知功能、日常生活能力(ADL)、中醫(yī)證候積分,檢測治療前后血清IGF-1、NO和ET-1。結果治療第3、6個月時,兩組認知功能MMSE、MoCA評分均高于同組治療前(P均0.05),ADL評分、中醫(yī)證候積分低于同組治療前(P均0.05);觀察組治療第6個月MMSE、MoCA評分均高于對照組而ADL評分低于對照組,第3、6個月中醫(yī)證候積分均低于對照組,差異有統(tǒng)計學意義(P均0.05)。治療第6個月兩組血清IGF-1、NO水平均高于同組治療前,ET-1水平低于同組治療前,差異有統(tǒng)計學意義(P均0.05);觀察組治療第6個月血清IGF-1、NO水平高于對照組,血清ET-1水平低于對照組,差異有統(tǒng)計學意義(P均0.05)。結論在常規(guī)西藥治療基礎上輔助應用復方菖蒲益智顆粒治療VCI,可升高血清IGF-1、NO水平而降低ET-1水平,提高臨床療效。
[Abstract]:Objective to observe the efficacy of compound Acorus Yizhi granules in the treatment of vascular cognitive dysfunction (VCI) and its effect on serum insulin-like growth factor 1 (IGF-1). Effects of nitric oxide (NO) and endothelin 1 (ET-1) levels. Methods 102 patients with VCI were randomly divided into two groups: the observation group (n = 51) and the control group (n = 51). Both groups were treated with western medicine orally (nimodipine, olaxetam capsule), and the observation group with compound Acorus Yizhi granules for 6 months. To compare the scores of TCM syndromes of cognitive function and daily living ability of (ADL), before and after treatment between the two groups, and to detect serum IGF-1,NO and ET-1. before and after treatment. Results at the 3rd and 6th month after treatment, the MMSE,MoCA scores of cognitive function in the two groups were higher than those in the same group before treatment (all P 0. 05), ADL), and the scores of TCM syndromes were lower than those of the same group before treatment (all P 0. 05). The MMSE,MoCA score of the observation group was higher than that of the control group at the 6th month and the ADL score was lower than that of the control group. The scores of TCM syndromes in the 3rd and 6th months were lower than those in the control group (P < 0. 05). At the 6th month after treatment, the serum IGF-1,NO levels of the two groups were higher than those of the same group before treatment, and the level of ET-1 was lower than that of the same group before treatment (P < 0. 05). The serum IGF-1,NO level and serum ET-1 level in the observation group were significantly higher than those in the control group at the 6th month after treatment (P < 0. 05). Conclusion the treatment of VCI, with compound Acorus Yizhi granules on the basis of routine western medicine treatment can increase the level of serum IGF-1,NO, decrease the level of ET-1, and improve the clinical efficacy.
【作者單位】： 河北省中醫(yī)院;滄州中西醫(yī)結合醫(yī)院;晉州市人民醫(yī)院;
【基金】：河北省科技計劃項目(15277748D) 河北省中醫(yī)藥類重大醫(yī)學科研課題(zyzd2013004)
【分類號】：R749.13
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本文編號：2396560