【摘要】：目的:觀察銀杏葉提取物片聯(lián)合丁苯酞軟膠囊對(duì)阿爾茨海默病的療效及安全性。方法:將我院收治的80例阿爾茨海默病患者作為資料進(jìn)行研究(納入時(shí)間為2014年10月~2016年8月)。其中40例給予丁苯酞治療(對(duì)照組),另外40例給予銀杏葉提取物片聯(lián)合丁苯酞軟膠囊治療(觀察組)。分析兩組治療的療效、相關(guān)量表進(jìn)步情況、血清有關(guān)因子變化以及藥物安全性。結(jié)果:治療6個(gè)月后,觀察組總有效率為82.50%,高于對(duì)照組60.00%(p0.05)。兩組經(jīng)治療,MMSE、ADAS-cog和ADL得分均較治療前進(jìn)步(均p0.05);觀察組以上三個(gè)量表得分分別為(20.38±1.17、31.19±0.97、27.94±1.15)分,均優(yōu)于對(duì)照組(17.37±1.14、35.16±1.02、32.02±1.09)分(均p0.05)。兩組經(jīng)治療,血漿NO和血清VEGF和MDA水平均優(yōu)于治療前(均p0.05);觀察組以上三個(gè)指標(biāo)水平分別為(44.07±1.04μmol/L、180.6±8.7ng/L、2.12±0.34μmol/L),均優(yōu)于對(duì)照組(37.96±0.97μmol/L、169.4±8.2ng/L、3.28±0.38μmol/L)(均p0.05)。對(duì)照組在治療期間出現(xiàn)15.00%的不良反應(yīng)比例,高于觀察組10.00%,但差異無統(tǒng)計(jì)學(xué)意義(p0.05)。結(jié)論:銀杏葉提取物片能提高阿爾茨海默病的治療效果,改善患者血清學(xué)相關(guān)指標(biāo),且不良反應(yīng)少。
[Abstract]:Objective: to observe the efficacy and safety of ginkgo leaf extract tablet combined with butyphthalide soft capsule in the treatment of Alzheimer's disease. Methods: 80 patients with Alzheimer's disease were treated in our hospital as data (from October 2014 to August 2016). 40 cases were treated with butyphthalide (control group), the other 40 cases were treated with Ginkgo biloba extract tablet combined with butyphthalide soft capsule (observation group). To analyze the curative effect of the two groups, the progress of related scales, the changes of serum related factors and the safety of drugs. Results: after 6 months of treatment, the total effective rate of the observation group was 82.50, which was higher than that of the control group (60.00%, p0.05). After treatment, the scores of MMSE,ADAS-cog and ADL in both groups were improved compared with those before treatment (p0.05). The scores of the above three scales in the observation group were (20.38 鹵1.17) 31.19 鹵0.97 鹵27.94 鹵1.15, respectively, which were higher than those in the control group (17.37 鹵1.14 鹵35.16 鹵1.02 鹵1.09) (p0.05). The levels of plasma NO and serum VEGF and MDA in both groups were higher than those before treatment (all p0.05). The above three indexes in the observation group were (44.07 鹵1.04 渭 mol/L,180.6 鹵8.7 ng / L, 2.12 鹵0.34 渭 mol/L), which were higher than those in the control group (37.96 鹵0.97 渭 mol/L,169.4 鹵8.2 ng / L). 3.28 鹵0.38 渭 mol/L (all p0.05). The proportion of adverse reactions in the control group was 15.00%, which was higher than that in the observation group (10.00%), but the difference was not statistically significant (p0.05). Conclusion: Ginkgo biloba extract tablet can improve the therapeutic effect of Alzheimer's disease, improve the serological related indexes, and have less adverse reactions.
【作者單位】： 海南醫(yī)學(xué)院附屬醫(yī)院;
【分類號(hào)】：R749.16

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