【摘要】：目的：收集并建立新疆維吾爾族及其他少數(shù)民族精神分裂癥的臨床資料及基因組DNA數(shù)據(jù)庫，，分析新疆維吾爾族及其他少數(shù)民族精神分裂癥患者初次入院病人與多次反復(fù)入院病人的文化程度、職業(yè)、遺傳等方面的影響以及兩組病人主要臨床表現(xiàn)的差異及預(yù)后評估。方法：收集新疆維吾爾族及其他少數(shù)民族住院病人的一般臨床資料并登記入“精神疾病家系調(diào)查表”，抽取外周靜脈血，提取基因組DNA并存入新疆醫(yī)科大學(xué)一附院重大疾病資源標(biāo)本庫保存。以住院次數(shù)將病人分為初次入院及反復(fù)入院兩組，并運(yùn)用PANSS和BPRS量表對其進(jìn)行評定及分析。結(jié)果：新疆維吾爾族及其他少數(shù)民族精神分裂癥多次入院與初次入院的患者中文化程度與職業(yè)p＜0.05，存在統(tǒng)計學(xué)差異；新疆少數(shù)民族精神分裂癥兩組病人BPRS評分與PANSS評分中，兩量表總分、BPRS的缺乏活力因子中、PANSS的陽性癥狀與陰性癥狀量表中均p＜0.05，得分有統(tǒng)計學(xué)差異。而PANSS量表一般精神病理量表，BPRS焦慮抑郁、思維障礙、激活性及敵對性四個因子中p＞0.05，提示得分沒有統(tǒng)計學(xué)意義，其臨床表現(xiàn)可能基本相同。結(jié)論：新疆維吾爾族及其他少數(shù)民族精神分裂癥的患者存有遺傳傾向性；初次入院與多次反復(fù)入院的患者的文化程度及職業(yè)有明顯差異，兩組患者的主要臨床表現(xiàn)也有明顯的差別，這對其預(yù)后及用藥方面有重大意義。
[Abstract]:Objective: to collect and establish the clinical data and genomic DNA database of schizophrenia of Uygur and other ethnic minorities in Xinjiang. To analyze the influence of education, occupation and heredity on the first admission and repeated admission of patients with schizophrenia of Uygur nationality and other ethnic minorities in Xinjiang, and the difference of main clinical manifestations and prognosis between the two groups. Methods: the general clinical data of inpatients of Uygur nationality and other ethnic minorities in Xinjiang were collected and registered in the Family questionnaire of Mental Disorders, and peripheral venous blood was extracted. Genomic DNA was extracted and stored in the resource library of major diseases in the first affiliated Hospital of Xinjiang Medical University. The patients were divided into first admission group and recurrent admission group according to the number of hospitalization. The patients were assessed and analyzed by PANSS and BPRS. Results: in Xinjiang Uygur nationality and other ethnic minorities, there were significant differences in education level and occupation (p < 0.05). In the BPRS score and PANSS score of Xinjiang minority schizophrenia patients, the total score of the two scales, the lack of vitality factor of BPRS, the positive symptoms of PANSS and the negative symptom scale were all P < 0.05, and there was statistical difference between the two scales (p < 0.05). But the general psychopathological scale of PANSS, BPRS anxiety and depression, mental disorder, activation and hostility of the four factors (p > 0.05) suggested that the score was not statistically significant, and its clinical manifestations may be basically the same. Conclusion: the patients with schizophrenia in Xinjiang Uygur nationality and other minority nationalities have genetic tendency. There were significant differences in education level and occupation between the first admission group and the repeated admission group, and there were significant differences in the main clinical manifestations between the two groups, which was of great significance to the prognosis and medication.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R749.3;TP311.13

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