【摘要】：目的:分析精神分裂癥患者血清輕稀土元素水平與精神分裂癥的關(guān)系。方法:應(yīng)用電感耦合等離子體質(zhì)譜儀(ICP-MS)測定30例精神分裂癥患者入院用藥前(病例組)、臨床痊愈時(痊愈組)和30例健康人(對照組)血清中的輕稀土元素含量。結(jié)果:與健康對照組相比,病例組血清中鑭、鈰和鐠3種元素的含量明顯增高,釹元素在兩組間的差異無統(tǒng)計學(xué)意義;痊愈組血清中鈰和鐠兩種元素的含量明顯增高,鑭和釹元素在兩組間的差異無統(tǒng)計學(xué)意義。血清中鑭、鈰、鐠、釹的含量在病例組和痊愈組之間的差異無統(tǒng)計學(xué)意義。結(jié)論:精神分裂癥患者血清中鑭、鈰、鐠3種輕稀土元素的含量有明顯變化,提示精神分裂癥患者體內(nèi)可能存在稀土元素的失調(diào)。
[Abstract]:Objective: to analyze the relationship between serum light rare earth element level and schizophrenia. Methods: the contents of light rare earth elements in serum of 30 schizophrenic patients (case group), 30 healthy persons (control group) and 30 healthy persons (control group) were measured by inductively coupled plasma mass spectrometer (ICP-MS). Results: compared with the healthy control group, the contents of lanthanum, cerium and praseodymium in the serum of the case group were significantly increased, but the difference of neodymium in the two groups was not statistically significant, and the contents of cerium and praseodymium in the serum of the cured group were obviously increased. There was no significant difference in lanthanum and neodymium between the two groups. The contents of lanthanum, cerium, praseodymium and neodymium in serum had no significant difference between the two groups. Conclusion: the contents of lanthanum, cerium and praseodymium in serum of schizophrenic patients have obvious changes, suggesting that there may be maladjustment of rare earth elements in patients with schizophrenia.
【作者單位】： 北京大學(xué)公共衛(wèi)生學(xué)院;山東省濰坊市精神衛(wèi)生中心;北京大學(xué)食品安全毒理學(xué)研究與評價北京市重點實驗室;
【基金】：北京大學(xué)醫(yī)學(xué)交叉學(xué)科種子基金項目“精神分裂癥及對照人群外周血中無機元素、膽固醇、免疫復(fù)合物的同步分析與數(shù)據(jù)挖掘”(BMU20140435)
【分類號】：R749.3

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