【摘要】：目的:探討血管性癡呆與血清GDF-15濃度的相關(guān)性,為預(yù)測(cè)血管性癡呆尤其是中醫(yī)瘀血阻絡(luò)證的的發(fā)生、發(fā)展提供依據(jù)。方法:使用隨機(jī)數(shù)字表法隨機(jī)選擇2016.01-2017.01在南京軍區(qū)福州總醫(yī)院神經(jīng)內(nèi)科住院的符合納入標(biāo)準(zhǔn)的血管性癡呆患者60例,年齡在45-80歲之間,南京軍區(qū)福州總醫(yī)院體檢中心體檢的符合對(duì)照組標(biāo)準(zhǔn)的對(duì)照組30例,年齡在45-80歲之間。對(duì)入組的每位患者進(jìn)行基本資料登記、簡(jiǎn)易精神量表(MMSE)、缺血指數(shù)量表(HIS)、日常生活自理能力量表(ADL)、中醫(yī)癥候辨證量表(SDSVD)、臨床癡呆程度量表測(cè)定(CDR)的測(cè)定并記錄。所有納入的患者在入院24小時(shí)內(nèi)進(jìn)行采集空腹肘靜脈血3ml,對(duì)照組于體檢時(shí)進(jìn)行采集空腹血3ml,所采集的靜脈血均置于分離膠真空管中,于室溫下靜置4-6小時(shí),采用真空分離機(jī)分離出血清后置于-70。C冰箱中。采用雙抗體夾心ABC-ELISA法進(jìn)行檢測(cè)。結(jié)果:血管性癡呆組血清GDF-15的濃度高于對(duì)照組,比較差異具有統(tǒng)計(jì)學(xué)意義(P≤0.05)。血管性癡呆患者癡呆嚴(yán)重程度比較中,重度組血清GDF-15濃度最高,明顯高于其它兩組,三組比較具有統(tǒng)計(jì)學(xué)意義(P≤0.05)。血清GDF-15濃度在多發(fā)梗死性癡呆組、關(guān)鍵部位梗死性癡呆組、皮質(zhì)下動(dòng)脈硬化性腦病組三組之間比較無(wú)統(tǒng)計(jì)學(xué)意義P≤0.05)。瘀血阻絡(luò)組患者血清GDF-15濃度明顯高于非瘀血阻絡(luò)組患者,二者差異具有統(tǒng)計(jì)學(xué)意義(P≤0.05)。血瘀重度組血清GDF-15濃度最高,明顯高于其它兩組,三組之間比較具有統(tǒng)計(jì)學(xué)意義(P≤0.05)。結(jié)論:(1)血管性癡呆組GDF-15濃度高于對(duì)照組,癡呆的程度與GDF-15成正相關(guān),提示GDF-15與血管性癡呆密切相關(guān),可能為血管性癡呆的診斷、病情進(jìn)展提供依據(jù)。(2)血管性癡呆瘀血阻絡(luò)組的血清GDF-15濃度高于非瘀血阻絡(luò)組,血瘀積分與GDF-15濃度正相關(guān),提示血清GDF-15濃度與血管性癡呆瘀血阻絡(luò)證的關(guān)系密切,可能為血管性癡呆瘀血阻絡(luò)證的辨證提供依據(jù)。
[Abstract]:Objective: to explore the correlation between vascular dementia and serum GDF-15 concentration in order to predict the occurrence and development of vascular dementia, especially the syndrome of blood stasis and collaterals obstruction in traditional Chinese medicine. Methods: sixty patients with vascular dementia, aged between 45 and 80 years, who were admitted to Department of Neurology, Fuzhou General Hospital of Nanjing military region, were randomly selected by random digital table method. 30 cases of the control group, aged between 45 and 80 years, met the standard of the control group in the physical examination center of Fuzhou General Hospital of Nanjing military region. The basic data of each patient in the group were registered, and (CDR) was measured and recorded by (MMSE), Ischemia Index scale (HIS), Self-care ability scale (ADL), TCM Syndrome differentiation scale (SDSVD), Clinical dementia scale (SDSVD),). All the patients received 3 ml of fasting elbow vein blood within 24 hours of admission, while the control group collected 3 ml of fasting blood during physical examination. The collected venous blood was placed in the vacuum tube of seperating glue and remained still for 4-6 hours at room temperature. The serum was separated by vacuum separator and placed in-70. C refrigerator. Double antibody sandwich ABC-ELISA method was used. Results: the concentration of serum GDF-15 in vascular dementia group was higher than that in control group, the difference was statistically significant (P 鈮，

本文編號(hào)：2220418