溶酶體異常與甲醛代謝失調(diào)及老年認(rèn)知損害
發(fā)布時(shí)間:2018-09-01 06:54
【摘要】:正最近,Wyss-Coray在其題為《衰老,神經(jīng)退行及恢復(fù)腦活力》的文章中~([1])闡述了血液中的一些蛋白因子在一定程度上具有恢復(fù)腦活力和延緩腦老化的作用.文章還強(qiáng)調(diào),異常溶酶體(abnormal lysosome,AL)的積累是腦老化過程中的典型現(xiàn)象之一.AL無法降解和清除受損生物大分子,使腦內(nèi)異常蛋白質(zhì)聚積,包涵體增加,從而破壞蛋白質(zhì)
[Abstract]:Recently, Wyss-Coray, in his article entitled "Aging, neurodegenerative and brain rejuvenation", stated that some protein factors in blood can restore brain vitality and delay brain aging to some extent. It is also emphasized that the accumulation of abnormal lysosomes (abnormal lysosome,AL) is one of the typical phenomena during brain aging. Al can not degrade and remove damaged biomolecules, which leads to the accumulation of abnormal proteins and the increase of inclusion bodies in the brain, thus destroying proteins.
【作者單位】: 中國科學(xué)院生物物理研究所 腦與認(rèn)知科學(xué)國家重點(diǎn)實(shí)驗(yàn)室;
【分類號】:R749.1
本文編號:2216451
[Abstract]:Recently, Wyss-Coray, in his article entitled "Aging, neurodegenerative and brain rejuvenation", stated that some protein factors in blood can restore brain vitality and delay brain aging to some extent. It is also emphasized that the accumulation of abnormal lysosomes (abnormal lysosome,AL) is one of the typical phenomena during brain aging. Al can not degrade and remove damaged biomolecules, which leads to the accumulation of abnormal proteins and the increase of inclusion bodies in the brain, thus destroying proteins.
【作者單位】: 中國科學(xué)院生物物理研究所 腦與認(rèn)知科學(xué)國家重點(diǎn)實(shí)驗(yàn)室;
【分類號】:R749.1
【相似文獻(xiàn)】
相關(guān)期刊論文 前2條
1 彭雪華;龍志敏;駱世芳;賀桂瓊;;溶酶體酶抑制劑對神經(jīng)細(xì)胞內(nèi)Nicastrin表達(dá)水平的影響[J];中國老年學(xué)雜志;2012年14期
2 ;[J];;年期
相關(guān)會(huì)議論文 前1條
1 欒萍;王軍;劉軍;;Ⅴ-ATPase功能缺陷致小膠質(zhì)細(xì)胞溶酶體對Aβ降解異常在AD發(fā)病機(jī)制中的作用[A];中國的遺傳學(xué)研究——遺傳學(xué)進(jìn)步推動(dòng)中國西部經(jīng)濟(jì)與社會(huì)發(fā)展——2011年中國遺傳學(xué)會(huì)大會(huì)論文摘要匯編[C];2011年
相關(guān)碩士學(xué)位論文 前1條
1 鄭邦旭;星形膠質(zhì)細(xì)胞溶酶體與β-淀粉樣蛋白的相互作用機(jī)制研究[D];寧波大學(xué);2015年
,本文編號:2216451
本文鏈接:http://sikaile.net/yixuelunwen/jsb/2216451.html
最近更新
教材專著