金匱腎氣丸改善抑郁癥病人疲勞感的臨床研究
發(fā)布時(shí)間：2018-08-23 20:49
【摘要】：目的探討金匱腎氣丸改善腎虛肝郁型抑郁癥病人疲勞感的療效。方法 60例抑郁癥病人按數(shù)字表法隨機(jī)分為研究組(金匱腎氣丸方合并草酸艾司西酞普蘭治療)和對照組(草酸艾司西酞普蘭治療),每組30例,對照組給予草酸艾司西酞普蘭治療,開始劑量10 mg/d,2周內(nèi)增至20 mg/d,每天1次,晨起頓服。研究組在此基礎(chǔ)上加用金匱腎氣丸(制附片6 g,桂枝12 g,牛膝10 g,車前子15 g,熟地黃10 g,澤瀉10 g,山萸肉12 g,淮山藥10 g,茯苓30 g,牡丹皮12 g,1日1劑,早晚各1次,每次200 mL),2組均治療8周。在治療前及治療的2、4、8周末分別采用疲勞量表-14(Fatigue Scale-14,FS-14)、疲勞自評量表(Fatigue Self Assessment Scale,FSAS)、漢密爾頓抑郁量表(Hamilton Depression Scale,HAMD)評分,并評價(jià)治療效果。結(jié)果研究組總有效率為86.7%,對照組為60%,差異有統(tǒng)計(jì)學(xué)意義(P=0.039)。研究組FS-14量表評分比較,治療2周、4周、8周末研究組均低于對照組,差異有統(tǒng)計(jì)學(xué)意義(P0.01),重復(fù)測量方差分析顯示,評定時(shí)間主效應(yīng)顯著(F=495.021,P=0.000),兩組治療2周末、4周末、8周末的FS-14評分均較治療前降低,評定時(shí)間組別的交互作用顯著(F=40.923,P=0.000),組間效應(yīng)顯著(F=17.516,P=0.000)。研究組FSAS量表評分比較,治療2周、4周、8周末研究組均低于對照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05),重復(fù)測量方差分析顯示,評定時(shí)間主效應(yīng)顯著(F=2 687.437,P=0.000),2組治療2周末、4周末、8周末的FSAS評分均較治療前降低,評定時(shí)間組別的交互作用顯著(F=574.799,P=0.000),組間效應(yīng)顯著(F=8.087,P=0.006)。研究組HAMD評分治療2、4、8周末均較對照組降低,差異有統(tǒng)計(jì)學(xué)意義(P0.05),重復(fù)測量方差分析顯示,評定時(shí)間主效應(yīng)顯著(F=317.61,P=0.000),2組治療2周末、4周末、8周末的HAMD評分均較治療前降低,評定時(shí)間組別的交互作用顯著(F=9.374,P=0.001),組間效應(yīng)顯著(F=4.593,P=0.037)。結(jié)論金匱腎氣丸治療伴發(fā)疲勞感的抑郁癥病人療效顯著,起效更快,值得臨床推廣應(yīng)用。
[Abstract]:Objective to investigate the effect of Jinkui Shenqi pills on fatigue of depression patients with kidney deficiency and liver depression. Methods Sixty patients with depression were randomly divided into study group (Jinkui Shenqi pills combined with oxalcitalopram) and control group (30 cases in each group). The control group was treated with estalopram oxalate. The initial dose was increased to 20 mg/d, once a day within 10 mg/d,2. The study group added Jinkui Shenqi pills (6 g of Fu Pian, 12 g of Guizhi, 10 g of Achyranthes bidentata, 15 g of Plantago, 10 g of cooked Rehmannia, 10 g of Rhizoma Alismatis, 12 g of Cornel, 10 g of Huai yam, 30 g of Poria cocos, 12 g of Peony Peel, 1 dose each day and morning and evening). Two groups were treated for 8 weeks. The scores of fatigue scale -14 (Fatigue Scale-14,FS-14), fatigue self-rating scale (Fatigue Self Assessment Scale,FSAS) and Hamilton depression scale (Hamilton Depression Scale,HAMD) were used before treatment and at the end of 8 weeks after treatment. Results the total effective rate of the study group was 86.7 and that of the control group was 60. The difference was statistically significant (P0. 039). The scores of FS-14 in the study group were significantly lower than those in the control group at the end of 2 weeks, 4 weeks and 8 weeks after treatment (P0.01). The main effect of evaluation time was significant (FF495.021 P0. 000). The FS-14 scores of the two groups were lower than those before treatment. The interaction between the two groups was significant (FF40.923 / P0. 000) and the intergroup effect was significant (FF17. 516 / P0. 000). The scores of FSAS in the study group were significantly lower than those in the control group at the end of 2 weeks, 4 weeks and 8 weeks after treatment (P0.05). The FSAS scores of the two groups were significantly lower than those before treatment, the interaction between the two groups was significant (FF574.799P0.000), and the inter-group effect was significant (FF8.087mP0.006). The main effect of the evaluation time was significant (FY26687.437) and the FSAS scores of the two groups were significantly lower than those of the patients before treatment at the end of the week and at the end of the 4th week and the 8th week after treatment (FF574.779 P0. 000). The HAMD score of the study group was significantly lower than that of the control group at the 8th week of treatment (P0.05), and repeated measurement variance analysis showed that the main effect of the evaluation time was significant (F _ (317.61) P _ (0.000) the HAMD scores of the two groups were lower than those of the control group at the end of the 2nd week and the end of the 4th week and the 8th week. The intergroup interaction was significant (F9.374 P0. 001) and the intergroup effect was significant (F4. 593 P0. 037). Conclusion Jingui Shenqi Pill is effective in treating depression patients with fatigue, and it is worth popularizing.
【作者單位】： 無錫市精神衛(wèi)生中心中西醫(yī)結(jié)合精神科;
【基金】：國家中醫(yī)藥管理局中醫(yī)重點(diǎn)�？�(ZJ1001SZ011)~~
【分類號】：R749.4
[Abstract]:Objective to investigate the effect of Jinkui Shenqi pills on fatigue of depression patients with kidney deficiency and liver depression. Methods Sixty patients with depression were randomly divided into study group (Jinkui Shenqi pills combined with oxalcitalopram) and control group (30 cases in each group). The control group was treated with estalopram oxalate. The initial dose was increased to 20 mg/d, once a day within 10 mg/d,2. The study group added Jinkui Shenqi pills (6 g of Fu Pian, 12 g of Guizhi, 10 g of Achyranthes bidentata, 15 g of Plantago, 10 g of cooked Rehmannia, 10 g of Rhizoma Alismatis, 12 g of Cornel, 10 g of Huai yam, 30 g of Poria cocos, 12 g of Peony Peel, 1 dose each day and morning and evening). Two groups were treated for 8 weeks. The scores of fatigue scale -14 (Fatigue Scale-14,FS-14), fatigue self-rating scale (Fatigue Self Assessment Scale,FSAS) and Hamilton depression scale (Hamilton Depression Scale,HAMD) were used before treatment and at the end of 8 weeks after treatment. Results the total effective rate of the study group was 86.7 and that of the control group was 60. The difference was statistically significant (P0. 039). The scores of FS-14 in the study group were significantly lower than those in the control group at the end of 2 weeks, 4 weeks and 8 weeks after treatment (P0.01). The main effect of evaluation time was significant (FF495.021 P0. 000). The FS-14 scores of the two groups were lower than those before treatment. The interaction between the two groups was significant (FF40.923 / P0. 000) and the intergroup effect was significant (FF17. 516 / P0. 000). The scores of FSAS in the study group were significantly lower than those in the control group at the end of 2 weeks, 4 weeks and 8 weeks after treatment (P0.05). The FSAS scores of the two groups were significantly lower than those before treatment, the interaction between the two groups was significant (FF574.799P0.000), and the inter-group effect was significant (FF8.087mP0.006). The main effect of the evaluation time was significant (FY26687.437) and the FSAS scores of the two groups were significantly lower than those of the patients before treatment at the end of the week and at the end of the 4th week and the 8th week after treatment (FF574.779 P0. 000). The HAMD score of the study group was significantly lower than that of the control group at the 8th week of treatment (P0.05), and repeated measurement variance analysis showed that the main effect of the evaluation time was significant (F _ (317.61) P _ (0.000) the HAMD scores of the two groups were lower than those of the control group at the end of the 2nd week and the end of the 4th week and the 8th week. The intergroup interaction was significant (F9.374 P0. 001) and the intergroup effect was significant (F4. 593 P0. 037). Conclusion Jingui Shenqi Pill is effective in treating depression patients with fatigue, and it is worth popularizing.
【作者單位】： 無錫市精神衛(wèi)生中心中西醫(yī)結(jié)合精神科;
【基金】：國家中醫(yī)藥管理局中醫(yī)重點(diǎn)�？�(ZJ1001SZ011)~~
【分類號】：R749.4
【參考文獻(xiàn)】
相關(guān)期刊論文 前10條
1 蘇曉云;李文青;馮春梅;賀繼平;崔建梅;;雌激素對去卵巢大鼠抑郁樣行為及杏仁核NGF表達(dá)的影響[J];中國醫(yī)科大學(xué)學(xué)報(bào);2016年12期
2 劉長穩(wěn);;金匱腎氣丸[J];開卷有益—求醫(yī)問藥;2015年08期
3 付正豐;龔明;苗家偉;岳秀永;陳春梅;嚴(yán)磊;陳華;;金匱腎氣丸溫補(bǔ)腎陽藥理作用的實(shí)驗(yàn)研究[J];中成藥;2015年05期
4 王雨桐;王蕾;;金匱腎氣丸的臨床和藥理實(shí)驗(yàn)研究進(jìn)展[J];中醫(yī)藥導(dǎo)報(bào);2015年05期
5 李賽;李東;;金匱腎氣丸臨床應(yīng)用辨析[J];中華中醫(yī)藥雜志;2015年03期
6 李海聰;楊毅玲;;金匱腎氣丸治療老年疑難疾病臨床應(yīng)用[J];中華中醫(yī)藥雜志;2015年03期
7 莊紅艷;畢葳;賈z嚴(yán)，
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