發(fā)布時(shí)間：2018-08-04 08:30

【摘要】：目的探討齊拉西酮輔助治療老年重癥精神分裂患者認(rèn)知功能的療效及對(duì)血清腦源性神經(jīng)生長(zhǎng)因子水平的影響。方法重癥精神分裂老年患者106例,按隨機(jī)數(shù)字表法分組,對(duì)照組53例予以?shī)W氮平治療,研究組53例予以齊拉西酮聯(lián)合奧氮平治療,評(píng)定認(rèn)知功能,采血檢測(cè)血清相關(guān)指標(biāo)、炎癥指標(biāo),同時(shí)對(duì)比臨床療效及并發(fā)癥。結(jié)果對(duì)照組治療有效率75.47%,低于研究組90.57%(P0.05);與對(duì)照組比較,研究組治療后神經(jīng)認(rèn)知功能狀況改善更顯著,治療后血清神經(jīng)生長(zhǎng)因子(NGF)、腦源性神經(jīng)生長(zhǎng)因子(BDNF)水平升高,血清膠質(zhì)纖維酸性蛋白因子(GFAP)水平降低,治療后血清白細(xì)胞介素(IL)-2、IL-6及腫瘤壞死因子(TNF)-α水平升高(P0.05)。結(jié)論采用齊拉西酮輔助治療老年重癥精神分裂患者療效顯著,對(duì)認(rèn)知功能、血清BDNF水平有改善作用。
[Abstract]:Objective to investigate the effect of ziprasidone on cognitive function and the level of brain-derived nerve growth factor (BGF) in elderly patients with severe schizophrenia. Methods 106 elderly patients with severe schizophrenia were randomly divided into control group (53 cases) treated with olanzapine and study group (53 cases) treated with ziprasidone combined with olanzapine. Inflammatory indexes were compared with clinical efficacy and complications. Results the effective rate of treatment in the control group was 75.47%, which was lower than that in the study group (90.57%, P0.05). Compared with the control group, the neurocognitive function in the study group was improved significantly, and the level of brain-derived nerve growth factor (BDNF) in serum nerve growth factor (NGF), was increased after treatment. The level of serum glial fibrillary acidic protein factor (GFAP) was decreased, and the levels of interleukin (IL) (IL)-2 (IL-6) and tumor necrosis factor (TNF)-偽 were increased after treatment (P0.05). Conclusion Ziprasidone is effective in the treatment of elderly patients with severe schizophrenia. It can improve cognitive function and serum BDNF level.
【作者單位】： 華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬精神衛(wèi)生中心;武漢市中醫(yī)醫(yī)院;
【分類(lèi)號(hào)】：R749.3

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