【摘要】：目的:探討6~18歲高功能孤獨(dú)癥患者的灰質(zhì)體積異常腦區(qū)以及異常腦區(qū)發(fā)育特點(diǎn)。方法:納入19例6~18歲符合美國(guó)精神障礙診斷與統(tǒng)計(jì)手冊(cè)第4版孤獨(dú)癥診斷標(biāo)準(zhǔn)且總智商≥70的高功能孤獨(dú)癥患者,以及年齡、總智商、性別組間匹配的16例正常對(duì)照,以磁共振成像檢查收集被試的腦影像學(xué)資料,采用基于體素的形態(tài)學(xué)測(cè)量方法計(jì)算兩組被試大腦各區(qū)域的灰質(zhì)體積,在統(tǒng)計(jì)學(xué)參數(shù)圖(SPM)軟件SPM8中進(jìn)行雙樣本t檢驗(yàn)得出差異腦區(qū),對(duì)結(jié)果進(jìn)行錯(cuò)誤率(FDR)多重比較校正(P0.05)。采用偏相關(guān)分析兩組被試差異腦區(qū)灰質(zhì)體積與年齡的相關(guān)性。結(jié)果:高功能孤獨(dú)癥組的右側(cè)額下回眶額部灰質(zhì)體積小于正常對(duì)照組(FDR校正,P0.05)。正常對(duì)照組右側(cè)額下回眶額部灰質(zhì)體積與年齡呈負(fù)相關(guān)(r=-0.592,P0.05),高功能孤獨(dú)癥患者右側(cè)額下回眶額部灰質(zhì)體積與年齡呈負(fù)相關(guān)(r=-0.696,P0.01)。結(jié)論:與正常人相比,6~18歲高功能孤獨(dú)癥患者右側(cè)額下回眶額部發(fā)育異常,此腦區(qū)可能參與孤獨(dú)癥的病理機(jī)制。
[Abstract]:Objective: to investigate the developmental characteristics of abnormal gray matter volume and abnormal brain area in 6 ~ 18 years old patients with high function autism. Methods: nineteen high-functioning autistic patients aged 6 to 18 years who met the criteria for diagnosis of autism in the fourth edition of the American Manual for diagnosis and Statistics of Mental Disorder and their total IQ 鈮，

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