本文選題：海洛因成癮 + 沖動(dòng)�。� 參考：《安徽醫(yī)科大學(xué)》2012年碩士論文

【摘要】：目的綜合海洛因成癮者沖動(dòng)行為的反應(yīng)模式、與沖動(dòng)行為相關(guān)的腦區(qū)功能定位及負(fù)性結(jié)果所誘發(fā)的事件相關(guān)電位波形特點(diǎn)，從決策行為角度來(lái)解釋海洛因成癮和復(fù)吸的神經(jīng)機(jī)制。 方法（1）利用神經(jīng)心理學(xué)實(shí)驗(yàn)范式，海洛因成癮組（HA組）和健康對(duì)照組（HC組）分別執(zhí)行愛荷華賭博任務(wù)（IGT），分析比較兩組被試沖動(dòng)行為反應(yīng)模式的差異；（2）對(duì)兩組被試在執(zhí)行愛荷華賭博任務(wù)（IGT）時(shí)同步進(jìn)行功能磁共振成像（fMRI）掃描，數(shù)據(jù)采集后使用統(tǒng)計(jì)參數(shù)圖軟件（SPM5）進(jìn)行分析，對(duì)與沖動(dòng)性決策行為相關(guān)的腦區(qū)進(jìn)行功能定位，并了解其功能變化；（3）對(duì)兩組被試在執(zhí)行愛荷華賭博任務(wù)（IGT）時(shí)進(jìn)行事件相關(guān)電位（ERP）描記，數(shù)據(jù)采集后分析比較兩組被試負(fù)性結(jié)果所誘發(fā)的事件相關(guān)電位的波幅和潛伏期，并與沖動(dòng)性量表（BIS-11）的測(cè)評(píng)結(jié)果作相關(guān)分析。 結(jié)果（1）HA組的IGT決策進(jìn)程對(duì)其凈分?jǐn)?shù)無(wú)顯著影響，但HC組有顯著影響（P0.05）；HA組所選低頻懲罰的紙牌數(shù)目與高頻懲罰紙牌相比無(wú)統(tǒng)計(jì)學(xué)差異，但HC組有統(tǒng)計(jì)學(xué)差異（P0.05），而被試選擇低頻懲罰與高頻懲罰的紙牌數(shù)目差值，兩組之間有統(tǒng)計(jì)學(xué)差異（P0.05）。（2）fMRI發(fā)現(xiàn)兩組被試執(zhí)行IGT時(shí)主要激活前額葉，其中右側(cè)前額葉眶部（OFC）、右側(cè)額葉背外側(cè)部（DLPFC）、左側(cè)前額葉腹內(nèi)側(cè)部（VMPFC）和前扣帶回（ACC）均有激活；HA組的右側(cè)OFC的激活程度強(qiáng)于HC組，但右側(cè)DLPFC和左側(cè)MPFC的激活強(qiáng)度低于HC組；除前額葉外，HA組的右側(cè)豆?fàn)詈恕⒂覀?cè)丘腦、右側(cè)島葉、海馬、左側(cè)尾狀核亦出現(xiàn)激活（統(tǒng)計(jì)閾值概率設(shè)為P0.05）。（3）兩組被試在Fz、Cz、Pz和Oz等導(dǎo)聯(lián)均出現(xiàn)明顯的錯(cuò)誤相關(guān)負(fù)波（ERN）、反饋相關(guān)負(fù)波（FRN）和P300的波形，在ERN、FRN中，兩組被試的波幅差異有統(tǒng)計(jì)學(xué)意義（P0.05）；在P300中，兩組被試的的波幅和潛伏期差異均有統(tǒng)計(jì)學(xué)意義。Pearson相關(guān)分析顯示，，兩組間ERN波幅與BIS評(píng)分呈負(fù)相關(guān)，相關(guān)系數(shù)分別為r=-0.66，-0.78（P0.05），而兩組潛伏期與BIS評(píng)分相關(guān)性不顯著（均P0.05）； FRN波幅與BIS評(píng)分呈正相關(guān)，相關(guān)系數(shù)分別為r=0.77，0.61（P0.05），而兩組潛伏期與BIS評(píng)分相關(guān)性不顯著（均P0.05）；HA組P300波幅、潛伏期與BIS評(píng)分均呈負(fù)相關(guān)，相關(guān)系數(shù)分別為r=-0.76，-0.52（P0.05），而HC組相關(guān)性均不顯著（P0.05）。 結(jié)論海洛因成癮者在反應(yīng)模式上存在沖動(dòng)性決策障礙；前額葉等沖動(dòng)性決策行為相關(guān)的腦區(qū)存在功能異常；負(fù)性結(jié)果所誘發(fā)的事件相關(guān)電位特征波形ERN、FRN和P300均存在異常，但與沖動(dòng)行為存在一定的相關(guān)性，提示海洛因成癮者錯(cuò)誤加工能力、結(jié)果評(píng)價(jià)能力及注意功能存在異常；上述均可能是成癮行為的產(chǎn)生、維持及維持的原因之一。
[Abstract]:Objective to synthesize the impulsive behavior patterns of heroin addicts, the functional localization of the brain regions associated with impulsive behavior and the characteristics of the event related potential waves induced by negative results, and to explain the neuromechanism of heroin addiction and relapse from the perspective of decision-making behavior.
Methods (1) using the neuropsychological experimental paradigm, the heroin addiction group (HA group) and the healthy control group (group HC) performed the Iowa gambling task (IGT) and analyzed the differences in the impulse response patterns of the two groups. (2) the two groups were synchronized with the functional magnetic resonance imaging (fMRI) scan in the implementation of the Iowa gambling task (IGT), and the number of them was scanned by functional magnetic resonance imaging (fMRI). According to the acquisition of statistical parameter map software (SPM5), the functional localization of brain regions related to impulsive decision making behavior and their functional changes were investigated. (3) the event related potential (ERP) was recorded in the two groups of subjects in the execution of Iowa gambling task (IGT), and the negative results of the two groups were compared after the data collection analysis. The amplitude and latency of event-related potentials were analyzed and correlated with the results of Impulsivity Scale (BIS-11).
Results (1) the IGT decision-making process in group HA had no significant effect on its net score, but there was a significant impact on the HC group (P0.05). There was no statistical difference between the number of cards selected by the HA group and the high frequency penalty card, but there was a statistical difference between the HC group (P0.05), and the difference between the low frequency penalty and the high frequency punishments was selected, and the two groups had statistics. (2) (2) (2) fMRI found that the prefrontal lobes were mainly activated in the two groups, of which the right prefrontal lobe (OFC), the lateral dorsal part of the right frontal lobe (DLPFC), the left prefrontal lobes (VMPFC) and the anterior cingulate gyrus (ACC) were activated, and the activation degree of OFC in the right side of HA group was stronger than that in the HC group, but the activation intensity of DLPFC and left MPFC was low. In group HC, the right lenticular nucleus in group HA, right thalamus, right Island lobe, hippocampus, and left caudate nucleus were also activated (statistical threshold probability was set to P0.05). (3) the two groups had obvious error related negative waves (ERN) in the lead of Fz, Cz, Pz and Oz, feedback related negative waves (FRN) and P300, in ERN, FRN, two groups The amplitude difference was statistically significant (P0.05); in P300, the amplitude and latency difference of the two groups were statistically significant.Pearson correlation analysis showed that the ERN wave amplitude was negatively correlated with the BIS score, the correlation coefficient was r=-0.66, -0.78 (P0.05), while the correlation between the two groups was not significantly correlated with the BIS score (P0.05), and the FRN wave amplitude was not significant. The correlation coefficient was positively correlated with the BIS score, and the correlation coefficient was r=0.77,0.61 (P0.05), while the latency of the two groups was not significantly correlated with the BIS score (P0.05), and the P300 wave amplitude in the HA group was negatively correlated with the BIS score, and the correlation coefficient was r=-0.76, -0.52 (P0.05), but the HC group correlation was not significant.
Conclusion the heroin addicts have impulsive decision disorder in the response pattern; the brain regions related to impulsive decision behavior such as prefrontal lobe are abnormal in the brain, and there are abnormal ERN, FRN and P300 induced by negative results, but there is a certain correlation with impulse behavior, suggesting that heroin addicts are wrong. The above results may be one of the reasons for the emergence, maintenance and maintenance of addictive behaviors.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R749.61

【共引文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 車敬超;跨期選擇理論、短視行為和財(cái)務(wù)報(bào)告舞弊傾向：理論分析與實(shí)驗(yàn)檢驗(yàn)[D];東北財(cái)經(jīng)大學(xué);2012年

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