本文選題：認知功能障礙 + Klotho��； 參考：《新疆醫(yī)科大學(xué)》2013年碩士論文

【摘要】：目的：探討新疆維、漢兩民族老年人輕度認知功能障礙(MCI）與Klotho蛋白之間的關(guān)系；同時探討Klotho蛋白在不同民族及性別中有無差異及其與血脂、血糖、血壓、年齡等指標(biāo)的相關(guān)性。方法：采用分層、隨機、多級整群抽樣的方式對新疆地區(qū)維、漢兩民族≥60歲老年常住居民進行MCI流行病學(xué)調(diào)查，納入資料完整的MCI患者161例（MCI組），，其中維吾爾族90人，漢族71人；同時選取民族、性別、年齡及血壓相匹配的非MCI者161例（對照組），其中維吾爾族88人，漢族73人。采用酶聯(lián)免疫吸附法（ELISA）檢測血清中Klotho蛋白濃度。結(jié)果：（1）MCI組Klotho蛋白濃度（2.48±1.40）ug/L顯著低于其對照組的（3.07±1.39）ug/L（P0.05）；（2）維族MCI組的Klotho蛋白濃度（2.21±1.30）ug/L顯著低于漢族MCI組的（2.81±1.42）ug/L（P0.05)；維族對照組的Klotho蛋白濃度（2.84±1.36）ug/L顯著低于漢族對照組的（3.34±1.37）ug/L（P0.05)。（3）男性MCI組的Klotho蛋白濃度（2.30±1.08）ug/L低于女性MCI組的（2.65±1.60）ug/L，兩組間比較差異無統(tǒng)計學(xué)意義（P0.05)；男性對照組的Klotho蛋白濃度（2.91±1.18）ug/L低于女性對照組的（3.22±1.55）ug/L，兩組間比較差異亦無統(tǒng)計學(xué)意義（P0.05)。（4）Klotho蛋白與年齡存在負相關(guān)(P0.05)，與膽固醇、低密度脂蛋白、MMSE及MoCa評分存在正相關(guān)(P0.05)；但未發(fā)現(xiàn)Klotho蛋白與體重、腹圍、血糖、血壓、高密度脂蛋白等指標(biāo)存在相關(guān)性（P0.05）。結(jié)論：（1）Klotho蛋白與MCI的發(fā)病相關(guān)，推測體內(nèi)其濃度的降低可能促進了MCI的發(fā)生發(fā)展。（2）Klotho蛋白在不同民族間存在差異，且維吾爾族低于漢族。但在不同性別間無明顯差異。（3）隨著人體年齡的增長，體內(nèi)Klotho蛋白含量有下降趨勢。（4）研究發(fā)現(xiàn)Klotho蛋白與膽固醇、低密度脂蛋白存在相關(guān)性，但未發(fā)現(xiàn)與血糖、血壓、高密度脂蛋白、腹圍及體重有相關(guān)性。
[Abstract]:Objective: to investigate the relationship between mild cognitive impairment (MCI) and Klotho protein in the elderly of Uygur and Han nationalities in Xinjiang, and to explore the relationship between Klotho protein and blood lipids, blood glucose, blood pressure, age and so on. Methods: stratified, random and multistage cluster sampling was used to investigate the MCI epidemiology of residents aged more than 60 years old in Xinjiang area. 161 MCI patients (MCI group) with complete data were included, 90 of them were Uygur. There were 71 cases of Han nationality, 161 cases of non-MCI matched by nationality, sex, age and blood pressure (control group), including 88 cases of Uygur nationality and 73 cases of Han nationality. Enzyme linked immunosorbent assay (Elisa) was used to detect the concentration of Klotho protein in serum. Results: (1) the concentration of Klotho protein in MCI group (2.48 鹵1.40) ugP / L was significantly lower than that in MCI group (3.07 鹵1.39) ugP / L (P0.05); (2), and was significantly lower than that in MCI group (2.81 鹵1.42) ug-r-L (P0.05). The concentration of Klotho protein in Uygur group (2.84 鹵1.36) ugP / L was significantly lower than that in Han nationality control group (3.34 鹵1.37) ugP / L (P0.05). The Klotho protein concentration in male MCI group was (2.30 鹵1.08) ugpr / L lower than that in female MCI group (2.65 鹵1.60) ugP / L, there was no significant difference between the two groups (P0.05). The concentration of Klotho protein was (2.91 鹵1.18) ug-L in male control group and (3.22 鹵1.55) ug-L in female control group. There was no significant difference between the two groups (P0.05). Klotho protein was negatively correlated with age (P0.05), and positively correlated with cholesterol, low density lipoprotein (LDL-C) MMSE and MoCa score (P0.05). But there was no correlation between Klotho protein and body weight, abdominal circumference, blood sugar, blood pressure, high density lipoprotein (P0.05). Conclusion: (1) Klotho protein is related to the pathogenesis of MCI, and the decrease of Klotho protein may promote the development of MCI. (2) Klotho protein is different among different nationalities, and it is lower in Uygur than in Han nationality. But there was no significant difference between sexes. (3) with the increase of age, the content of Klotho protein decreased. (4) the study found that Klotho protein was correlated with cholesterol and low density lipoprotein, but not with blood sugar and blood pressure. High density lipoprotein (HDL), abdominal circumference and weight were correlated.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R749.16

【參考文獻】

相關(guān)期刊論文 前9條

1 李湘民;周巧玲;;高血壓腦損害患者血清Klotho蛋白水平測定及相關(guān)危險因素分析[J];第三軍醫(yī)大學(xué)學(xué)報;2010年08期

2 劉彬,韶紅,彭永革,丁惠瑩;對深圳羅湖區(qū)老年人輕度認知障礙的調(diào)查與分析[J];廣州中醫(yī)藥大學(xué)學(xué)報;2005年05期

3 高jK若生 ,劉芳;輕度認知功能障礙[J];日本醫(yī)學(xué)介紹;2005年03期

4 唐榮;周巧玲;彭衛(wèi)生;湯天鳳;涂珊;敖翔;;血管緊張素Ⅱ?qū)δI小管上皮細胞Klotho基因表達的影響[J];腎臟病與透析腎移植雜志;2008年03期

5 何亞軍;蘇顯明;王新陽;;Klotho蛋白在高血壓發(fā)病中的作用[J];西安交通大學(xué)學(xué)報(醫(yī)學(xué)版);2010年04期

6 蘇顯明;何亞軍;劉景委;智曉文;;Klotho蛋白與心力衰竭患者腎臟損害的相關(guān)性[J];西安交通大學(xué)學(xué)報(醫(yī)學(xué)版);2011年06期

7 蘭丹鳳;楊秋萍;;Klotho與2型糖尿病并動脈粥樣硬化關(guān)系的研究進展[J];醫(yī)學(xué)綜述;2011年13期

8 杜洪霞;張湛睿;彌曼;;Klotho蛋白對帕金森病模型小鼠的神經(jīng)保護作用[J];中國老年學(xué)雜志;2009年17期

9 劉曉林;馬厚勛;田小春;吳平;周平;李法琦;;Klotho基因3個SNP位點與老年高血壓及脂代謝的相關(guān)性[J];中國老年學(xué)雜志;2010年23期

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