本文選題：注意網(wǎng)絡(luò)測查 + 抑郁癥　； 參考：《浙江大學(xué)》2013年碩士論文

【摘要】：目的： 本研究擬通過比較抑郁癥個(gè)體和健康人群的注意網(wǎng)絡(luò)測查(Attention Network Test, ANT)測查成績,比較根據(jù)ANT成績指導(dǎo)用藥和經(jīng)驗(yàn)用藥治療抑郁癥的療效,探究ANT在抑郁癥診療中的作用。 方法： 1.以健康人群ANT測查成績建立正常樣本數(shù)據(jù),了解抑郁癥組ANT成績,事件相關(guān)電位(Event Related Potentials, ERPs)波形與正常對照有無差異。 2.以是否根據(jù)ANT成績指導(dǎo)用藥分為干預(yù)組和對照組,比較治療后ANT測查成績、臨床心理評估等各項(xiàng)指標(biāo)的組間差異。 3.結(jié)合事件相關(guān)電位定性比較治療前后兩組相應(yīng)的頭皮波幅分布圖。 結(jié)果： 1.根據(jù)健康人群ANT測查結(jié)果確定ANT測查行為學(xué)正常值的范圍為警覺網(wǎng)絡(luò)效率正常值范圍：16.54-52.06；定向網(wǎng)絡(luò)效率正常值范圍：21.75-62.19；執(zhí)行控制網(wǎng)絡(luò)效率正常值范圍：51.1-166.54。與正常樣本數(shù)據(jù)比較,抑郁癥組的警覺網(wǎng)絡(luò)效率、定向網(wǎng)絡(luò)效率和執(zhí)行控制網(wǎng)絡(luò)效率均顯著異常。 2.抑郁癥患者的執(zhí)行控制網(wǎng)絡(luò)ERPs波形與正常對照組相似,在前額葉區(qū)域(FPZ/F1/F2)在200-400ms存在P200-400,在枕葉區(qū)域(01/02)和頂葉區(qū)域(PZ)存在200-400ms的N200-400。抑郁癥組在FPZ的P200-400波幅均顯著小于正常對照組(P0.05)；抑郁癥組在中央提示和雙重提示條件下誘發(fā)的波形與正常對照組基本相似,正常對照組在T6電極較抑郁癥組誘發(fā)出更負(fù)的N150-250(P0.05),在枕葉中央?yún)^(qū)域(OZ)較抑郁癥組誘發(fā)出更正的P150-250(P0.05)；抑郁癥組在空間提示條件下誘發(fā)的波形與正常對照組基本相似,正常對照組在OZ較抑郁癥組誘發(fā)出更正的P150-250(P0.05)。 3.藥物治療后2、4、6、8周的簡明精神病評定量表(Brief Psychiatric Rating Scale, BPRS),總分、蒙哥馬利抑郁評定量(Montgomery-Asberg depression rating scale, MADRS),總分和臨床療效總評量表(Clinical Global Impression scale, CGI-GI),總分比較,除第2周BPRS總分、第6周、第8周的CGI-GI評分組間比較無顯著性差異外,其他組間比較均存在顯著性差異。 4.藥物治療后8周的ANT測查行為學(xué)結(jié)果顯示干預(yù)組ANT測查的正確率、警覺網(wǎng)絡(luò)效率和執(zhí)行控制網(wǎng)絡(luò)效率顯著好于非干預(yù)組。兩組間在正確的反應(yīng)時(shí)間和定向網(wǎng)絡(luò)效率上無顯著性差異。 5.治療后8周ANT測查ERPs頭皮波幅分布圖顯示干預(yù)組執(zhí)行控制網(wǎng)絡(luò)成分300-400ms的前額葉區(qū)域激活明顯大于非干預(yù)組；干預(yù)組中央提示和雙重提示誘發(fā)的ERPs成分150-250ms的前額葉區(qū)域激活明顯大于非干預(yù)組,左側(cè)顳枕區(qū)激活明顯大于非干預(yù)組；干預(yù)組空間提示誘發(fā)的ERPs成分150-250ms的頭皮波幅分布圖與非干預(yù)組基本相似。結(jié)論： 1.抑郁癥患者存在注意網(wǎng)絡(luò)功能的障礙。 2.采用注意網(wǎng)絡(luò)測查成績指導(dǎo)抑郁癥藥物治療能提高療效。 3.采用注意網(wǎng)絡(luò)測查成績指導(dǎo)抑郁癥藥物能提高抑郁癥患者的注意網(wǎng)絡(luò)功能。
[Abstract]:Objective: the purpose of this study was to compare the results of attention Network Test (ANT) test of depression individuals and healthy people, and to compare the efficacy of drug use and experiential medication in the treatment of depression according to ant scores. To explore the role of ant in the diagnosis and treatment of depression. Methods: 1. To establish the normal sample data from the ANT test results of healthy population, to understand the ANT scores, event related potentials (ERPs) waveforms of depression group and the normal control. 2. The patients were divided into intervention group and control group according to whether or not to guide drug use according to ANT scores. The differences of ANT test scores and clinical psychological evaluation were compared between groups. 3. The scalp amplitude distribution of the two groups before and after treatment was compared qualitatively with event-related potentials. Results: 1. According to the results of ant test in healthy population, the normal range of behavior of ant test is: normal value of alert network efficiency: 16.54-52.06; normal value of directed network efficiency: 21.75-62.19; normal value of executive control network efficiency: 51.1-166.54. Compared with normal sample data, the alertness network efficiency, directed network efficiency and executive control network efficiency of depression group were significantly abnormal. 2. The ERPs waveform of the executive control network in patients with depression was similar to that in the normal control group. There were P200-400 in 200-400ms, N200-400 in occipital area and N200-400 in parietal area. The amplitude of P200-400 in depression group was significantly lower than that in normal control group (P 0.05), and the waveform in depression group was similar to that in normal control group under central and double cues. In the normal control group, more negative N150-250 P0.05 was induced at the T6 electrode than in the depression group, and the corrected P150-250 P0.05 was induced in the central occipital area of the depression group, and the waveform in the depression group was similar to that in the normal control group under the spatial cues. In the normal control group, the corrected P150-250 P0.05A was induced in OZ group than that in the depression group. 3. Brief Psychiatric rating scale (BPRS), total score, Montgomery-Asberg depression rating scale, MADRSs, total score and clinical efficacy scale, CGI-GI, total score, except for the second week BPRS total score, the 6th week, the total score, the total score and the clinical global impact scale, CGI-GI, total score, Montgomery-Asberg depression rating scale, Madrid score, total score and clinical curative effect scale, CGI-GI, total score comparison, except for the 2nd week BPRS total score, the 6th week, There was no significant difference in CGI-GI score between the groups in the 8th week, but there was significant difference between the other groups. 4. After 8 weeks of drug therapy, the behavioral results of ant test showed that the correct rate of ANT test, alert network efficiency and executive control network efficiency in the intervention group were significantly better than those in the non-intervention group. There was no significant difference between the two groups in the correct reaction time and directional network efficiency. 5. 5. 8 weeks after treatment, the scalp amplitude distribution of ERPs by ANT showed that the activation of prefrontal area of 300-400ms in the intervention group was significantly higher than that in the non-intervention group. In the intervention group, the activation of the prefrontal area of 150-250ms was significantly greater than that of the non-intervention group, and the activation of the left temporooccipital area was significantly greater than that of the non-intervention group. The scalp amplitude distribution of 150-250ms induced by spatial cues in the intervention group was similar to that in the non-intervention group. Conclusion: 1. Depression patients have attention network dysfunction. 2. Using attention network test results to guide depression drug treatment can improve the efficacy. 3. Using attention network test to guide depression drugs can improve the attention network function of depression patients.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R749.4

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相關(guān)期刊論文 前2條

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本文編號：2021681