本文選題：BDNF基因 + 抑郁癥��； 參考：《昆明醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:研究首發(fā)未經(jīng)治療抑郁癥患者和健康對照的BDNF Va166Met基因型和全腦灰質(zhì)體積之間的關(guān)系。方法:本研究納入符合DSM-IV診斷標(biāo)準(zhǔn)的首發(fā)未經(jīng)治療抑郁障礙患者組41名以及性別、年齡相匹配的健康對照組44名,行頭部3D結(jié)構(gòu)磁共振掃描。根據(jù)BDNF基因分型結(jié)果將抑郁癥患者組和健康對照組進(jìn)一步分為,抑郁癥Met等位基因攜帶者組,抑郁癥Va1/Val純合子組,健康對照Met等位基因攜帶者組,健康對照Val純合子組。所得到的結(jié)構(gòu)磁共振數(shù)據(jù)采用基于Matlab 2012軟件平臺上的VBM 8軟件進(jìn)行自動(dòng)化分割處理,分別分割處理抑郁癥患者組和健康對照組的腦灰質(zhì)體積。全腦范圍,采用2x2 ANOVA全因子模型分析診斷和基因型對全腦灰質(zhì)體積影響分別的主效應(yīng)以及交互效應(yīng)。結(jié)果:1.抑郁癥患者組和健康對照組rs6265的等位基因頻率(p=0. 992833)和基因型分布(p=0.956498)兩組之間未顯示出統(tǒng)計(jì)學(xué)差異(P0. 05)。2.抑郁癥患者組與健康對照組相比,左側(cè)楔前葉增大(p0. 05)。3.2x2 ANOVA全因子模型分析結(jié)果顯示(p0.05) : (a)BDNF基因型對腦灰質(zhì)體積影響主效應(yīng):左側(cè)小腦、左側(cè)梭狀回減小,右側(cè)頂上回增大。(b)診斷對腦灰質(zhì)體積影響主效應(yīng):左側(cè)楔前葉增大。(c)BDNF基因與診斷對腦灰質(zhì)體積影響的交互效應(yīng):左側(cè)前扣帶回減小。在Val純合子組中,抑郁癥患者組與健康對照組相比,發(fā)現(xiàn)左側(cè)海馬旁回、右側(cè)前扣帶回灰質(zhì)體積減小。在Met等位基因組中,抑郁癥患者組與健康對照組相比,發(fā)現(xiàn)左側(cè)額中回、右側(cè)額中回灰質(zhì)體積增大。結(jié)論:1.與健康對照組相比,抑郁癥患者組左側(cè)楔前葉灰質(zhì)體積增大。2.本研究表明,rs6265位點(diǎn)的遺傳變異可能導(dǎo)致左側(cè)小腦、左側(cè)海馬旁回灰質(zhì)體積減小和右側(cè)頂上回灰質(zhì)體積增大。3.左側(cè)前扣帶回灰質(zhì)體積減小是BDNF和抑郁癥共同作用的結(jié)果,這提示BDNF Va166Met多態(tài)性可能在抑郁癥早期發(fā)病機(jī)制中發(fā)揮重要作用。
[Abstract]:Aim: to study the relationship between BDNF Va166Met genotype and global gray matter volume in untreated depression patients and healthy controls. Methods: 41 patients with untreated depressive disorder and 44 healthy controls matched with sex and age were enrolled in this study. According to the results of BDNF genotyping, the patients with depression and the healthy control group were further divided into Met allele carrier group, Va1/Val homozygous group, Met allele carrier group and Val homozygote group. The obtained structural magnetic resonance data were automatically segmented by VBM 8 software based on Matlab 2012 software platform. The gray matter volumes in depression group and healthy control group were segmented respectively. In the whole brain, the main effect and interaction effect of diagnosis and genotype on the whole brain gray matter volume were analyzed by 2x2 ANOVA full-factor model. The result is 1: 1. The allele frequency of rs6265 in depression group and healthy control group was 0. 0. There was no statistical difference between the two groups (P 0. 0) and genotype distribution (P 0. 956 49 8). 05. 2. Compared with the healthy control group, the patients with depression increased the left anterior cuneate lobe (P 0. 0). The results of 05).3.2x2 ANOVA full-factor model analysis showed that: the main effect of BDNF genotype on the gray matter volume was: the left cerebellum, the left fusiform gyrus decreased, and the left fusiform gyrus decreased in the left cerebellum. The main effects of right superior gyrus enlargement on gray matter volume were as follows: the interaction effect of BDNF gene of left anterior wedge enlargement and diagnosis on gray matter volume: the decrease of left anterior cingulate gyrus. In the Val homozygous group, the volume of gray matter in the right anterior cingulate gyrus was decreased in the depression group compared with the control group. In the Met allele, the left middle frontal gyrus and the right middle frontal gyrus were found to be larger in the depression group than in the healthy control group. Conclusion 1. Compared with the healthy control group, the gray matter volume of the left anterior cuneate lobe in the depression group increased by. 2. 2. This study suggests that the genetic variation at rs6265 may lead to a decrease in the volume of gray matter in the left cerebellum, a decrease in the volume of gray matter in the left parahippocampal gyrus and an increase in the volume of gray matter in the right superior parietal gyrus. The decrease of gray matter volume in left anterior cingulate gyrus is the result of BDNF and depression, which suggests that BDNF Va166Met polymorphism may play an important role in the early pathogenesis of depression.
【學(xué)位授予單位】：昆明醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R749.4

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相關(guān)期刊論文 前2條

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本文編號：1980991