本文選題：心房顫動 + 認知功能障礙　； 參考：《蘭州大學》2017年碩士論文

【摘要】：目的:心房顫動是老年人中最為常見的心律失常,隨著人口老齡化不斷加速,高血壓、糖尿病、冠心病等心血管相關疾病的患病率不斷增加,房顫的發(fā)病率在全球范圍內呈升高趨勢。許多國外研究表明,房顫可以導致非卒中性認知功能障礙并可加速認知功能進一步惡化,認知功能障礙導致個人生活質量的下降、家庭和社會的經濟負擔加重,成為人們逐漸關注的焦點。因此本研究通過對房顫及非房顫患者進行一般資料的統(tǒng)計及MMSE、MoCA量表認知功能評價,探討房顫與非卒中性認知功能障礙的相關性。方法:本研究以2015年4月-2016年10月就診于蘭州大學第二醫(yī)院心內科的非卒中房顫患者共99名設為病例組,以房顫患者性別、年齡、受教育程度為匹配因素納入99名非房顫患者作為對照組,記錄患者一般資料、統(tǒng)計患者輔助檢查結果,通過MMSE及MoCA量表對兩組患者進行認知功能評價,比較兩組患者認知功能障礙的患病情況。結果:1)通過MMSE量表評估,病例組患者存在認知功能障礙30人(30.3%),對照組患者存在認知功能障礙者18人(18.2%),兩組通過配對卡方檢驗示,P0.001,兩組差異有統(tǒng)計學意義。2)通過MoCA量表評估,病例組患者中存在認知障礙者90人(90.9%),對照組患者中存在認知障礙者73人(73.7%),P0.001,兩組差異有統(tǒng)計學意義。兩種量表檢查均提示病例組中認知功能障礙的患病率較高。結論房顫是導致非卒中性認知功能障礙的獨立危險因素。
[Abstract]:Objective: atrial fibrillation is the most common arrhythmia in the elderly, and the prevalence of cardiovascular diseases such as hypertension, diabetes, coronary heart disease and so on increases with the aging of the population. The incidence of atrial fibrillation is increasing worldwide. Many foreign studies have shown that atrial fibrillation can lead to non-stroke neutral cognitive dysfunction and accelerate the further deterioration of cognitive function, cognitive dysfunction leads to a decline in personal quality of life, family and social economic burden. Become the focus that people pay attention to gradually. Therefore, this study investigated the correlation between atrial fibrillation and non-stroke neutral cognitive dysfunction by statistical analysis of general data and evaluation of cognitive function of MMSE MoCA scale in patients with atrial fibrillation and non-atrial fibrillation. Methods: from April 2015 to October 2016, 99 patients with non-apoplectic atrial fibrillation in Department of Cardiology, second Hospital of Lanzhou University were selected as the case group. The educational level was matched by 99 non-atrial fibrillation patients as the control group. The general data of the patients were recorded and the results of auxiliary examination were counted. The cognitive function of the two groups was evaluated by MMSE and MoCA scale. To compare the prevalence of cognitive dysfunction between the two groups. Results according to the MMSE scale, 30 patients with cognitive dysfunction in the case group and 18 patients with cognitive dysfunction in the control group were assessed by MoCA scale. The matched chi-square test showed P 0.001. The difference between the two groups was statistically significant. 90 patients with cognitive impairment in the case group and 73 patients with cognitive impairment in the control group had cognitive impairment (P 0.001). The difference between the two groups was statistically significant. The prevalence of cognitive impairment was higher in the two scales. Conclusion Atrial fibrillation is an independent risk factor for non-apoplectic cognitive impairment.
【學位授予單位】：蘭州大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R541.75;R749.1

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