本文選題：腦卒中后抑郁焦慮共病(PSCAD) + 抑郁癥　； 參考：《安徽醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的 本實驗采用迷迭香復(fù)合精油吸嗅治療腦卒中后抑郁焦慮共�。≒SCAD）患者，通過測評患者的HAMD及HAMA評分，觀察治療前、后患者抑郁及焦慮癥狀改善情況，初步探討迷迭香復(fù)合精油治療抑郁和焦慮的臨床應(yīng)用價值。 方法 1.分組：遵循循證醫(yī)學(xué)，選取2012年2月至2013年5月在安徽醫(yī)科大學(xué)第一附屬醫(yī)院康復(fù)醫(yī)學(xué)科收治的腦卒中患者60例，采用隨機(jī)數(shù)字表法將上述患者分為治療組和對照組，每組各30例，2組患者的性別、文化程度、年齡、病程、卒中部位、卒中性質(zhì)及HAMD、HAMA評分等方面差異均無顯著性(P0.05)。 2.治療方法：2組患者均予以腦卒中常規(guī)康復(fù)治療。 （1）治療組：取迷迭香復(fù)合精油0.4ml，用20ml常溫純凈水稀釋后放入擴(kuò)香儀托盤中，放在50cm×40cm×30cm的密閉塑料盒中，，利用燈泡加熱，使用鼻導(dǎo)管吸入鼻孔內(nèi)，吸入時間為30min，每晚一次，治療時間為持續(xù)8周。 （2）對照組：口服舍曲林，每晚一次，每次50mg，治療時間為持續(xù)8周。 3.療效評價：分別于治療前、治療2W、治療4W、治療6W及治療8W后的五個時間點，采用HAMD量表和HAMA量表對2組患者進(jìn)行療效評定,上述測評均由相同2名經(jīng)專業(yè)培訓(xùn)的康復(fù)醫(yī)師完成。在治療過程中同時對2組患者進(jìn)行血常規(guī)、尿常規(guī)、肝腎功能及心電圖檢查，并密切觀察2組患者不良反應(yīng)發(fā)生情況。 結(jié)果 1．2組患者的HAMD評分比較結(jié)果：治療組和對照組HAMD評分在治療前、治療2W、治療4W、治療6W及治療8W后五個時間點的其間差異均有統(tǒng)計學(xué)意義（F=623.66，P=0.000），但2組患者HAMD評分在不同時間點組間差異均無統(tǒng)計學(xué)意義（P0.05）；2組患者治療前與治療8周末HAMD評分比較均有差異性（P0．01），治療后HAMD評分均呈下降趨勢，提示治療組HAMD評分與對照組相當(dāng)。 2.2組患者的HAMA評分比較結(jié)果：治療組和對照組HAMA評分在治療前、治療2W、治療4W、治療6W及治療8W后五個時間點的其間差異均有統(tǒng)計學(xué)意義（F=549.68，P=0.000），但2組患者HAMA評分在不同時間點組間差異均無統(tǒng)計學(xué)意義（P0.05）；2組患者治療前與治療8W末HAMA評分比較均有差異性（P0．01），治療后HAMA評分均呈下降趨勢，提示治療組HAMA評分與對照組相當(dāng)。 3.不良反應(yīng)：治療組與對照組治療8W后均無l例出現(xiàn)不良反應(yīng)，血常規(guī)、尿常規(guī)、肝腎功能及心電圖檢查均未見明顯異常改變。 結(jié)論 1.迷迭香復(fù)合精油吸嗅治療腦卒中后抑郁焦慮共病的臨床療效確切，可以顯著改善患者的抑郁及焦慮癥狀。 2.迷迭香復(fù)合精油吸嗅治療抑郁和焦慮癥狀的臨床療效與舍曲林相當(dāng)。 3.迷迭香復(fù)合精油吸嗅無明顯不良反應(yīng)，安全性高。
[Abstract]:Purpose In this experiment, rosemary combined with essential oil sniffing was used to treat patients with post-stroke depression and anxiety syndromes. The patients' HAMD and HAMA scores were evaluated to observe the improvement of depression and anxiety symptoms before and after treatment. To explore the clinical application value of Rosemary compound essential oil in the treatment of depression and anxiety. Method 1. Group: according to evidence-based medicine, 60 stroke patients treated in the Department of Rehabilitation Medicine, first affiliated Hospital of Anhui Medical University from February 2012 to May 2013, were randomly divided into treatment group and control group. There was no significant difference in sex, education level, age, course of disease, location of stroke, nature of stroke and Hamd Hama score between each group (30 cases) and two groups (P 0.05). 2. Methods: two groups of patients were treated with routine rehabilitation of stroke. 1) treatment group: Rosemary compound essential oil 0.4ml, diluted with 20ml pure water at room temperature, placed in the tray of diffuser, placed in the sealed plastic box of 50cm 脳 40cm 脳 30cm, heated by light bulb, inhaled into nostril with nasal catheter for 30 mins, once a night, The treatment lasted for 8 weeks. Control group: oral sertraline, once a night, 50 mg each time, the treatment lasted for 8 weeks. 3. Evaluation of curative effect: at the five time points before treatment, treatment of 2W, treatment of 4W, treatment of 6W and treatment of 8W, HAMD and HAMA were used to evaluate the curative effect of the two groups. The above evaluation was completed by the same two rehabilitators who were trained professionally. The blood routine, urine routine, liver and kidney function and electrocardiogram were examined in both groups during the course of treatment, and the adverse reactions of the two groups were observed closely. Result 1. 2 comparison of HAMD scores of patients in the treatment group and the control group: before treatment, the HAMD score of the treatment group and the control group, There were statistically significant differences among the five time points after treatment 2 W, 4 W, 6 W and 8 W, respectively. However, there was no significant difference in HAMD scores between the two groups before and after 8 weeks of treatment. The HAMD scores were significantly different (P 0.01), and the HAMD scores decreased after treatment. It suggested that the HAMD score of the treatment group was equal to that of the control group. 2.2 comparison of HAMA scores of patients in the treatment group and the control group: before treatment, the HAMA score in the treatment group and the control group, There were statistically significant differences among the five time points after treatment 2 W, 4 W, 6 W and 8 W, respectively. However, there was no significant difference in HAMA scores between the two groups at different time points. There was no significant difference between the two groups before treatment and at the end of 8 weeks of treatment, but there was no significant difference in HAMA scores between the two groups before treatment and at the end of 8 weeks of treatment. There were significant differences in the scores between the two groups (P 0.01), and the HAMA scores showed a downward trend after treatment. It suggested that the HAMA score of the treatment group was equal to that of the control group. 3. Adverse reactions: there were no adverse reactions in both the treatment group and the control group after 8 weeks treatment. There were no obvious abnormal changes in blood routine, urine routine, liver and kidney function and electrocardiogram. Conclusion 1. Rosemary combined with essential oil sniffing is effective in the treatment of post-stroke depression and anxiety syndromes, and can significantly improve the symptoms of depression and anxiety. 2. Rosemary combined with essential oil sniffing is as effective as sertraline in the treatment of depression and anxiety. 3. Rosemary compound essential oil sniffing no obvious adverse reaction, high safety.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R743.3;R749

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