本文選題：心臟神經(jīng)官能癥 + 同型半胱氨酸�。� 參考：《山東大學(xué)》2013年碩士論文

【摘要】：[目的]通過觀察心臟神經(jīng)官能癥(cardiac neurosis, CN)患者血清同型半胱氨酸(homocysteine, HCY)和脂聯(lián)素(adiponectin, APN)的水平變化,探討血清HCY與APN水平和CN的關(guān)系,為CN的進(jìn)一步診治研究奠定基礎(chǔ)。 [方法]選取我院CN患者(CN組)29例,男14例,女15例,平均年齡為(54.40+9.77)歲,選擇同期來(lái)我院就診的冠心病患者(CHD組)30例,男、女各15例,平均年齡為(57.80±9.57)歲,來(lái)我院進(jìn)行健康體檢者(對(duì)照組)29例,男13例,女16例,平均年齡為(55.30±9.56)歲。所有入選者取空腹外周靜脈血5mL,取上清液得血清標(biāo)本。采用酶聯(lián)免疫吸附(ELISA)法分別檢測(cè)29例CN患者,30例CHD患者及29名健康體檢者的血清HCY和APN的水平變化,并對(duì)檢測(cè)結(jié)果進(jìn)行分析。實(shí)驗(yàn)數(shù)據(jù)采用統(tǒng)計(jì)學(xué)軟件SPSS17.0進(jìn)行比較,計(jì)量資料用均數(shù)±標(biāo)準(zhǔn)差(x±s)來(lái)表示,多組間均數(shù)比較采用方差分析,P0.05為差異有統(tǒng)計(jì)學(xué)意義。 [結(jié)果]3組一般資料的比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。CN組、CHD組和對(duì)照組血清HCY水平分別為(19.17±4.22)nmol/ml、(22.86±4.84)nmol/ml和(11.73±3.01)nmol/ml,APN水平分別為(9.88±1.67)mg/L、(8.64±1.41)mg/L和(11.11±1.88)mg/L,三組間兩兩比較均差異有統(tǒng)計(jì)學(xué)意義(均P0.05)。對(duì)所有研究對(duì)象進(jìn)行血清HCY水平與APN水平的相關(guān)分析,顯示血清HCY水平與APN水平呈負(fù)相關(guān)(r=-0.413,P0.01)。 [結(jié)論]高HCY血癥和低APN血癥在CN的發(fā)生發(fā)展中起到了重要作用,這為CN的進(jìn)一步研究提供了新思路。
[Abstract]:[objective] to observe the changes of homocysteine (HCY) and adiponectin (APNs) in serum of patients with cardiac neurosis (CNN), and to explore the relationship between serum HCY and APN and CN, so as to lay a foundation for the further diagnosis and treatment of CN. [methods] A total of 29 patients (14 males and 15 females) with mean age of 54.409.77 years were selected from CN group in our hospital. 30 CHD patients (15 males and 15 females, mean age: 57.80 鹵9.57) were selected from CHD group. There were 29 healthy persons (control group, 13 males and 16 females, mean age: 55.30 鹵9.56). Fasting peripheral venous blood (5 mL) and supernatant were collected from all participants. The changes of serum HCY and APN levels in 29 patients with CN and 30 patients with CHD and 29 healthy controls were detected by Elisa and the results were analyzed. The experimental data were compared by statistical software SPSS17.0, the measurement data were expressed by mean 鹵standard deviation x 鹵s, and the differences between groups were statistically significant by means of ANOVA (P0.05). [results] there was no significant difference in general data among the three groups. The serum HCY levels were 19.17 鹵4.22nmol / ml (22.86 鹵4.84)nmol/ml) and 11.73 鹵3.01nmol / ml (8.64 鹵1.41)mg/L) and 11.11 鹵1.88mg / L (P 0.05) in the three groups, respectively. The correlation analysis of serum HCY level and APN level showed that there was a negative correlation between serum HCY level and APN level. [conclusion] High HCY and low APN play an important role in the occurrence and development of CN, which provides a new idea for the further study of CN.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R749.7

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本文編號(hào)：1948857