本文選題：廣泛性焦慮障礙 + 事件相關(guān)電位　； 參考：《大連醫(yī)科大學(xué)》2012年碩士論文

【摘要】：目的：廣泛性焦慮障礙(Generalized anxiety disorder, GAD)又稱慢性焦慮，臨床以對日常事件或活動的緊張不安及過度焦慮感為特征。盡管目前廣泛性焦慮障礙的發(fā)病機制研究尚未取得一致性的結(jié)論，但多數(shù)研究普遍提示情緒信息的加工異�？赡苁菑V泛性焦慮障礙的重要發(fā)病機制之一。 信息無意識加工的特點為無或極少意識參與的信息加工過程，不占用注意資源，無需意識發(fā)動。結(jié)合臨床GAD患者表現(xiàn)為無明確對象或固定內(nèi)容的緊張不安及過度焦慮感，推測GAD患者對情緒信息的加工異常很可能發(fā)生于無意識水平。情緒信息加工的研究表明，，情緒面孔所傳達的信息更容易以無意識方式進行加工。事件相關(guān)電位（event-related potentials, ERP）技術(shù)可以將時間精確到毫秒，能鎖時性的反映大腦認知加工的動態(tài)過程，是研究無意識加工的最佳技術(shù)手段。本研究目的是利用事件相關(guān)電位方法探討廣泛性焦慮障礙患者對情緒面孔無意識加工的特點，并進一步分析不同情緒內(nèi)容有無特異性。 方法：本研究采用閾下情緒啟動任務(wù)應(yīng)用64導(dǎo)Neuroscan腦電生理儀來記錄事件相關(guān)電位。記錄腦電后進行離線分析，分別測量額區(qū)、頂區(qū)、枕區(qū)及中央?yún)^(qū)不同情緒面孔誘發(fā)的P1成分和P3a成分的平均波幅及潛伏期。采用重復(fù)測量方差分析(Repeated measure ANOVA)對兩組ERP成分的平均波幅和潛伏期進行統(tǒng)計分析。 結(jié)果： 1.兩組被試在恐懼面孔條件下的情感等級評分存在顯著的組別差異(F_(1,28)=15.296, p 0.05)，GAD組的情感等級評分（4.521±0.221）明顯高于對照組（4.159±0.282）。 2.患者組的P1、P3a波幅均明顯高于對照組，有統(tǒng)計學(xué)意義（p 0.01）。對情緒效應(yīng)進一步分析發(fā)現(xiàn)，僅在患者組兩種情緒面孔具有統(tǒng)計學(xué)差異(p 0.05),表現(xiàn)為恐懼面孔誘發(fā)的P1波幅（12.634±0.057）大于高興面孔誘發(fā)的P1波幅(7.554±0.072)，而高興面孔誘發(fā)的P3a波幅(10.077±0.032)大于恐懼面孔誘發(fā)的P3a波幅（8.326±0.032）。 3.P1成分的峰值潛伏期存在顯著的組別主效應(yīng)，有統(tǒng)計學(xué)意義（F_(1,28)=3.598,p 0.01），表現(xiàn)為患者組的P1峰值潛伏期（100.579±0.46）較對照組（139.575±0.46）明顯提前。 4.兩種ERP成分的波幅均表現(xiàn)為右側(cè)半球波幅高于左側(cè)半球波幅(p 0.01)。 結(jié)論： 1.廣泛性焦慮障礙患者存在情緒面孔的無意識加工異常。 2.廣泛性焦慮障礙患者對情緒面孔的無意識加工異常存在情緒內(nèi)容特異性，表現(xiàn)為對負性情緒的無意識加工增強。 3.廣泛性焦慮障礙患者對情緒信息的自動加工存在加工偏側(cè)化，以右側(cè)半球加工為優(yōu)勢。
[Abstract]:Objective: generalized anxiety disorder, GAD), also known as chronic anxiety, is characterized by nervousness and overanxiety about daily events or activities. Although the research on the pathogenesis of generalized anxiety disorder has not reached a consistent conclusion, most studies generally suggest that abnormal processing of emotional information may be one of the important pathogenesis of generalized anxiety disorder. The process of information unconscious processing is characterized by unconsciousness or little participation in the process of information processing, which does not occupy attention resources and does not require conscious initiation. Combined with the nervous and excessive anxiety in clinical GAD patients with no definite object or fixed content, it is speculated that abnormal processing of emotional information in GAD patients is likely to occur at the unconscious level. The research of emotional information processing shows that emotional faces convey information more easily and unconsciously. Event-related potentials (ERPs), which can accurately time to millisecond, can reflect the dynamic process of cognitive processing in the brain and is the best technique to study unconscious processing. The purpose of this study was to explore the characteristics of unconscious processing of emotional faces in patients with generalized anxiety disorder by means of event-related potentials, and to further analyze the specificity of different emotional contents. Methods: a 64-lead Neuroscan electrophysiological instrument was used to record event-related potentials. After recording the EEG, the average amplitude and latency of P1 and P3a components induced by different emotional faces in frontal, parietal, occipital and central regions were measured. The average amplitude and latency of two groups of ERP components were statistically analyzed by repeated measure ANOVA. Results: 1. There was a significant difference in the scores of affective grade between the two groups under the condition of fear face. The scores of affective grade of the two groups were significantly higher than that of the control group (4.159 鹵0.282), while the scores of the affective grade of the GAD group were 4.521 鹵0.221 and 4.159 鹵0.282 respectively, which were significantly higher than those of the control group (4.159 鹵0.282). 2. The amplitudes of P _ (1) P _ (3) a in the patients group were significantly higher than those in the control group (P < 0.01). Further analysis of emotional effects found that, Only in the patients group, there was a statistical difference between the two emotional faces (P < 0.05), which showed that the P1 amplitude induced by fear faces was 12.634 鹵0.057), which was higher than that of happy faces (7.554 鹵0.072), while the P3a amplitude induced by happy faces was 10.077 鹵0.032), which was higher than that induced by fear faces (8.326 鹵0.032). The peak latency of 3.P1 was significantly earlier than that of control group (P < 0.05 鹵0.46), and the peak latency of 3.P1 was significantly earlier than that of control group (P < 0.01), which was significantly earlier than that of control group (P < 0.01). The peak latency of P 1 was 100.579 鹵0.46 in the patient group and 139.575 鹵0.46 in the control group. 4. The amplitudes of the two ERP components were higher in the right hemisphere than in the left hemisphere. Conclusion: 1. In patients with generalized anxiety disorder, the unconscious processing of emotional faces is abnormal. 2. The abnormal unconscious processing of emotional faces in patients with generalized anxiety disorder has emotional content specificity, which is manifested by the enhancement of unconscious processing of negative emotions. 3. The automatic processing of emotional information in patients with generalized anxiety disorder is lateralized, with the advantage of right hemisphere processing.
【學(xué)位授予單位】：大連醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R749.72

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相關(guān)期刊論文 前1條

1 王妍,羅躍嘉;大學(xué)生面孔表情材料的標準化及其評定[J];中國臨床心理學(xué)雜志;2005年04期

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