本文選題：輕度認知功能障礙 + 老年癡呆��； 參考：《安徽醫(yī)科大學》2012年碩士論文

【摘要】：目的隨著年齡的增長老年人常常因精神和體力方面能力下降影響其生活質(zhì)量。精神方面最顯著的功能變化是認知功能損害，這在老化過程中非常常見。但是許多老年人其認知功能損害的程度比同齡老年人嚴重的多。輕度認知功能障礙（MCI）被認為是介于正常老化與老年癡呆之間的過度階段。當今許多國家步入老齡化，MCI的流行率和發(fā)病率隨之增加。尋找改善MCI癥狀和延緩其發(fā)展的方法已經(jīng)成為老年癡呆防治的重中之重。本研究將對輕度認知功能損害的治療進行深入研究，探討大劑量葉酸聯(lián)合阿托伐他汀在輕度認知功能損害患者中的干預作用，積極尋找一種對輕度認知功能損害患者的有效預防和治療措施. 方法采用前瞻性的研究方法。收集門診及住院的患者，予以安慰劑服用兩周后，，抽取清晨空腹血，測同型半胱氨酸（Hcy），血脂及肝腎功能。再通過簡易智能狀態(tài)量表(MMSE)得分將納入的研究對象分為正常對照A組和MCI組。再根據(jù)是否給予葉酸聯(lián)合阿托伐他汀藥物干預治療隨機分為MCI未治療B組和MCI治療C組。予以藥物干預治療半年，藥物干預周期結(jié)束后再次復測血漿同型半胱氨酸、血脂、肝腎功能，及進行MMSE量表評定，并進行治療前后及兩組間對比。采用MMSE評分量表的措施，進一步探討葉酸聯(lián)合阿托伐他汀對MCI患者認知功能的改善情況。結(jié)果周期前后A組Hcy、TC及MMSE值均無明顯差異，統(tǒng)計學無顯著性差異（P＞0.05）；B組MMSE值較之前有所下降，其差異均有顯著性意義（P＜0.05），雖Hcy、TC水平有所上升，但無顯著性統(tǒng)計學意義；C組MMSE值較之前稍下降，但無顯著性統(tǒng)計學意義（P＞0.05），并且Hcy、TC水平也較之前顯著降低，其差異有顯著統(tǒng)計學意義（P＜0.05）。 結(jié)論兩組MCI患者血漿相較正常對照組Hcy及血脂存在著一定的代謝紊亂。認知功能損害的進展速率相較正常對照組快，兩組MCI患者之間相互比較得出葉酸聯(lián)合阿托伐他汀對MCI患者的認知功能的改善有一定作用，是一種有效的治療方法。
[Abstract]:Objective with age, the elderly often suffer from mental and physical decline in their quality of life. The most significant mental functional change is cognitive impairment, which is common during aging. But many older people have more severe cognitive impairment than their peers. Mild cognitive impairment (MCI) is thought to be a transitional stage between normal aging and Alzheimer's disease. The prevalence and incidence of MCI are increasing in many countries. Finding ways to improve the symptoms and delay the development of MCI has become a top priority in the prevention and treatment of Alzheimer's disease. In this study, the treatment of mild cognitive impairment was studied, and the intervention effect of high dose folic acid combined with Atto vastatin in patients with mild cognitive impairment was discussed. Actively looking for an effective prevention and treatment for patients with mild cognitive impairment. Methods A prospective study was used. After two weeks of placebo administration, fasting blood samples were collected from outpatients and inpatients. The levels of homocysteine, serum lipids, liver and kidney function were measured. The subjects included in the study were divided into normal control group A and MCI group. According to whether folic acid and Atto vastatin were given, the patients were randomly divided into two groups: group B without MCI and group C treated with MCI. The plasma homocysteine, blood lipid, liver and kidney function, and MMSE scale were measured again after the end of the drug intervention period, and the comparison was made between the two groups before and after the treatment. To further explore the improvement of cognitive function of MCI patients with folic acid combined with Atto vastatin by using MMSE scoring scale. Results there was no significant difference in TC and MMSE between group A and group A before and after the cycle. There was no significant difference in MMSE between group A and group B (P > 0.05), and the difference was significant (P < 0.05), although the level of TC in group A was higher than that in group B (P > 0.05). But there was no significant statistical significance in group C (P > 0.05), but there was no significant difference (P > 0.05), and the level of TC in group C was significantly lower than that in group C (P < 0.05). Conclusion compared with the normal control group, the plasma levels of Hcy and blood lipid in the two groups of MCI patients have some metabolic disorders. The development rate of cognitive impairment was faster than that of normal control group. The results showed that folic acid combined with Atto vastatin could improve the cognitive function of MCI patients and was an effective treatment method.
【學位授予單位】：安徽醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R749.16

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